Results 1 to 10 of about 33,156 (163)
Sialylated and sulfated N-Glycans in MDCK and engineered MDCK cells for influenza virus studies
Scientific Reports, 2022 The Madin-Darby canine kidney (MDCK) cell line is an in vitro model for influenza A virus (IAV) infection and propagation. MDCK-SIAT1 (SIAT1) and humanized MDCK (hCK) cell lines are engineered MDCK cells that express N-glycans with elevated levels of ...
Lauren Byrd-Leotis +6 more
doaj +3 more sources
Viruses, 2021 Madin–Darby canine kidney (MDCK) cells are commonly used for the isolation of mammalian influenza A viruses. The goal of this study was to compare the sensitivity and suitability of the original MDCK cell line in comparison with MDCK-derived cell lines ...
Yohannes Berhane
exaly +3 more sources
The MDCK variety pack: choosing the right strain [PDF]
BMC Cell Biology, 2011 The MDCK cell line provides a tractable model for studying protein trafficking, polarity and junctions (tight, adherens, desmosome and gap) in epithelial cells.
Chalmers Andrew D +2 more
doaj +4 more sources
Metabolomics profiling reveals differences in proliferation between tumorigenic and non-tumorigenic Madin-Darby canine kidney (MDCK) cells [PDF]
PeerJ, 2023 Background Madin-Darby canine kidney (MDCK) cells are a cellular matrix in the production of influenza vaccines. The proliferation rate of MDCK cells is one of the critical factors that determine the vaccine production cycle.
Na Sun +11 more
doaj +2 more sources
IRF7-deficient MDCK cell based on CRISPR/Cas9 technology for enhancing influenza virus replication and improving vaccine production [PDF]
PeerJ, 2022 The influenza virus is a cause of seasonal epidemic disease and enormous economic injury. The best way to control influenza outbreaks is through vaccination.
Oraphan Mayuramart +8 more
doaj +2 more sources
Acta Pharmaceutica, 2022 The Madin-Darby canine kidney (MDCK) cell line is frequently used for permeability screening in drug discovery. It contains endogenous transporters, most prominently canine multidrug resistance P-glycoprotein (Mdr1), which can interfere with studies of P-
BOKULIĆ ANA +3 more
doaj +1 more source
Pharmaceutics, 2020 Recently, various types of cultured cells have been used to research the mechanisms of transport and metabolism of drugs. Although many studies using cultured cell systems have been published, a comparison of different cultured cell systems has never ...
Tomoyuki Furubayashi +8 more
doaj +1 more source
Cell Volume Fluctuations in MDCK Monolayers [PDF]
Biophysical Journal, 2015 Cells moving collectively in tissues constitute a form of active matter, in which collective motion depends strongly on driven fluctuations at the single-cell scale. Fluctuations in cell area and number density are often seen in monolayers, yet their role in collective migration is not known.
Steven M., Zehnder +4 more
openaire +3 more sources
Pharmaceutics, 2023 Currently, the mechanisms involved in drug access to the central nervous system (CNS) are not completely elucidated, and research efforts to understand the behaviour of the therapeutic agents to access the blood–brain barrier continue with the utmost ...
Bárbara Sánchez-Dengra +4 more
doaj +1 more source
Polystyrene nanoparticle trafficking across MDCK-II [PDF]
Nanomedicine: Nanotechnology, Biology and Medicine, 2011 Polystyrene nanoparticles (PNP) cross rat alveolar epithelial cell monolayers via non-endocytic transcellular pathways. To evaluate epithelial cell type-specificity of PNP trafficking, we studied PNP flux across Madin Darby canine kidney cell II monolayers (MDCK-II).
Farnoosh, Fazlollahi +8 more
openaire +2 more sources