Sphingomyelin metabolism is involved in the differentiation of MDCK cells induced by environmental hypertonicity [PDF]
, 2015 Sphingolipids (SLs) are relevant lipid components of eukaryotic cells. Besides regulating various cellular processes, SLs provide the structural framework for plasma membrane organization.
Favale, Nicolas Octavio +4 more
core +1 more source
Viruses, 2019 Victoria and Yamagata lineages of influenza B viruses are globally circulating in seasonal epidemics. Madin−Darby canine kidney (MDCK) cells are permissive for viral isolation and vaccine manufacture. Nevertheless, the interplay between influenza B
Suthat Saengchoowong +6 more
doaj +1 more source
Autophagy induction regulates influenza virus replication in a time-dependent manner [PDF]
, 2017 Autophagy plays a key role in host defence responses against microbial infections by promoting degradation of pathogens and participating in acquired immunity.
Abdoli, Asghar +12 more
core +1 more source
Claudin-2 knockout by TALEN-mediated gene targeting in MDCK cells: claudin-2 independently determines the leaky property of tight junctions in MDCK cells. [PDF]
PLoS ONE, 2015 Tight junctions (TJs) regulate the movements of substances through the paracellular pathway, and claudins are major determinants of TJ permeability. Claudin-2 forms high conductive cation pores in TJs.
Shinsaku Tokuda, Mikio Furuse
doaj +1 more source
Functional evaluation for adequacy of MDCK-lineage cells in influenza research
BMC Research Notes, 2019 Objective Influenza is an acute respiratory disease caused by the influenza virus which circulates annually in populations of different species. Madin-Darby Canine Kidney (MDCK) is the most widely utilized cell-line for conducting influenza research ...
Hsin-Chung Tsai +4 more
doaj +1 more source
Substitutions near the hemagglutinin receptor-binding site determine the antigenic evolution of influenza A H3N2 viruses in U.S. swine [PDF]
, 2014 Swine influenza A virus is an endemic and economically important pathogen in pigs, with the potential to infect other host species. The hemagglutinin (HA) protein is the primary target of protective immune responses and the major component in swine ...
A. L. Vincent +58 more
core +2 more sources
High yield production of influenza virus in Madin Darby canine kidney (MDCK) cells with stable knockdown of IRF7. [PDF]
PLoS ONE, 2013 Influenza is a serious public health problem that causes a contagious respiratory disease. Vaccination is the most effective strategy to reduce transmission and prevent influenza.
Itsuki Hamamoto +3 more
doaj +1 more source
Proteolytic processing and activation of Clostridium perfringens epsilon toxin by caprine small intestinal contents. [PDF]
, 2014 Epsilon toxin (ETX), a pore-forming toxin produced by type B and D strains of Clostridium perfringens, mediates severe enterotoxemia in livestock and possibly plays a role in human disease.
Freedman, John C +3 more
core +2 more sources
Shear-induced Volume Decrease in MDCK Cells [PDF]
Cellular Physiology and Biochemistry, 2012 Using a microfluidic cell volume sensor we measured the change in the cell volume of Madin-Darby Canine Kidney (MDCK) cells induced by shear stress. An increase in shear stress from 0.2 to 2.0 dyn/cm(2) resulted in a volume decrease to a steady state volume ∼ 20 - 30 % smaller than the initial resting cell volume.
Jinseok, Heo +3 more
openaire +2 more sources
Scientific Reports, 2018 Trimethylamine-N-oxide (TMAO) gained considerable attention because of its role as a cardiovascular risk biomarker. Organic cation transporter 2 (OCT2) mediates TMAO uptake into renal proximal tubular cells.
A. Gessner, J. König, M. F. Fromm
doaj +1 more source