Results 21 to 30 of about 33,848 (196)
Elastic modulus and hydraulic permeability of MDCK monolayers [PDF]
Journal of Biomechanics, 2017 The critical role of cell mechanics in tissue health has led to the development of many in vitro methods that measure the elasticity of the cytoskeleton and whole cells, yet the connection between these local cell properties and bulk measurements of tissue mechanics remains unclear.
Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL, United States ( host institution ) +6 more
openaire +3 more sources
High yield production of influenza virus in Madin Darby canine kidney (MDCK) cells with stable knockdown of IRF7. [PDF]
PLoS ONE, 2013 Influenza is a serious public health problem that causes a contagious respiratory disease. Vaccination is the most effective strategy to reduce transmission and prevent influenza.
Itsuki Hamamoto +3 more
doaj +1 more source
Scientific Reports, 2018 Trimethylamine-N-oxide (TMAO) gained considerable attention because of its role as a cardiovascular risk biomarker. Organic cation transporter 2 (OCT2) mediates TMAO uptake into renal proximal tubular cells.
A. Gessner, J. König, M. F. Fromm
doaj +1 more source
Cl- and regulation of pH by MDCK-C11 cells [PDF]
Brazilian Journal of Medical and Biological Research, 2007 The interaction between H(+) extrusion via H(+)-ATPase and Cl(-) conductance was studied in the C11 clone of MDCK cells, akin to the intercalated cells of the collecting duct. Cell pH (pHi) was measured by fluorescence microscopy using the fluorescein-derived probe BCECF-AM.
Tararthuch, A.L. +2 more
openaire +5 more sources
Steviol reduces MDCK Cyst formation and growth by inhibiting CFTR channel activity and promoting proteasome-mediated CFTR degradation. [PDF]
PLoS ONE, 2013 Cyst enlargement in polycystic kidney disease (PKD) involves cAMP-activated proliferation of cyst-lining epithelial cells and transepithelial fluid secretion into the cyst lumen via cystic fibrosis transmembrane conductance regulator (CFTR) chloride ...
Chaowalit Yuajit +5 more
doaj +1 more source
Regulation of caveolin and caveolae by cholesterol in MDCK cells [PDF]
Journal of Lipid Research, 1998 We have examined the expression of caveolin in MDCK cells under conditions that vary cellular cholesterol concentration. Caveolin mRNA levels dropped to one-sixth of control levels after treatment with simvastatin, an inhibitor of cholesterol synthesis, or beta-trimethyl cyclodextrin (CD), a cholesterol sequestering drug.
Hailstones, D. +3 more
openaire +6 more sources
Comparison of mutation patterns in full-genome A/H3N2 influenza sequences obtained directly from clinical samples and the same samples after a single MDCK passage. [PDF]
PLoS ONE, 2013 Human influenza viruses can be isolated efficiently from clinical samples using Madin-Darby canine kidney (MDCK) cells. However, this process is known to induce mutations in the virus as it adapts to this non-human cell-line.
Hong Kai Lee +6 more
doaj +1 more source
PrPC Undergoes Basal to Apical Transcytosis in Polarized Epithelial MDCK Cells. [PDF]
PLoS ONE, 2016 The Prion Protein (PrP) is an ubiquitously expressed glycosylated membrane protein attached to the external leaflet of the plasma membrane via a glycosylphosphatidylinositol anchor (GPI).
Alexander Arkhipenko +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Ganglioside GM2 is substrate for a sialidase in MDCK cells
FEBS Letters, 1998 GM1 ganglioside carrying a fluorescent fatty acid in substitution of the natural one, has been administered to cultured Madin‐Darby canine kidney (MDCK) cells for different pulse times (0.5–24 h), and its metabolic fate was followed. The fluorescent GM2, asialo‐GM2, asialo‐GM1 and ceramide were the only detectable metabolites.
MARCHESINI, Sergio +4 more
openaire +2 more sources