Results 91 to 100 of about 41,345 (224)
Best Practices in Physiologically Based Pharmacokinetic (PBPK) Modeling
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling is a mechanistic cornerstone of model‐informed drug development (MIDD), providing evidence for regulatory decisions. PBPK models integrate physiological and pharmacological data and have been applied across a plethora of contexts of use, including assessing drug–drug interactions (DDIs ...
Marylore Chenel +6 more
wiley +1 more source
Cell viabilities of virus infected MDCK cells.
, 2017 Cellular viability was determined as the concentration of formazan product level. MTS tetrazolium compound was added into influenza-infected MDCK (A), MDCK-SIAT1 (B), and MDCK-London (C) at 24, 48, 72, and 96 hours post-infection followed by incubating ...
Shih-Chao Lin (3753646) +4 more
core +1 more source
Protective essential oil attenuates influenza virus infection: An in vitro study in MDCK cells
BMC Complementary and Alternative Medicine, 2010 Background Influenza is a significant cause of morbidity and mortality. The recent pandemic of a novel H1N1 influenza virus has stressed the importance of the search for effective treatments for this disease. Essential oils from aromatic plants have been
Metcalf Jordan P +5 more
doaj +1 more source
Influenza and Other Respiratory Viruses, Volume 20, Issue 7, July 2026.ABSTRACT Background The emergence of novel reassortant influenza A virus strains and zoonotic transmission to the human population is a critical factor in the development of a global pandemic, as exemplified by the 2009 swine flu pandemic and the ongoing threat of an H5N1 avian flu pandemic.
Nimisha Rikhi +6 more
wiley +1 more source
Sorting of the Human Folate Receptor in MDCK Cells
BMB Reports, 2004 The human folate receptor (hFR) is a glycosylphosphatidy-linositol (GPI) linked plasma membrane protein that mediates delivery of folates into cells. We studied the sorting of the hFR using transfection of the hFR cDNA into MDCK cells. MDCK cells are polarized epithelial cells that preferentially sort GPI-linked proteins to their apical membrane ...
Chong-Ho, Kim +3 more
openaire +3 more sources
TRPA1 is expressed in MDCK cells.
, 2013 (A) The TRPA1 agonists AITC, H2O2, MG and cinnamaldehyde stimulate [Ca2+]i-responses in MDCK cells. (B, C) The selective TRPA1 antagonist AP18 (10 µM) produces a rightward shift of AITC and MG evoked [Ca2+]i-responses in MDCK cells.
Clive Gentry (303153) +7 more
core +1 more source
Influence of HIV PIs on BBR uptake in MDCK cells.
, 2013 Wild-type MDCK and P-gp-transfected MDCK cells were treated with BBR (5 µM) in the presence of different amount of individual HIV PIs (5, 15, and 25 µM) or verapamil (100 µM) for 4 h, respectively.
Phillip B. Hylemon (253333) +12 more
core +1 more source
Varied efficacies of antiviral drugs on different MDCK-lineage cells.
, 2017 MDCK, MDCK-SIAT1, and MDCK-London were pretreated with two antiviral drugs, Oseltamivir carboxylate and Ribavirin, before Influenza infections. The concentrations of ribavirin and oseltamivir carboxylate started with 100 μg/mL followed by 2-fold serial ...
Shih-Chao Lin (3753646) +4 more
core +1 more source
, 2008 The ability to isolate and propagate influenza virus is an essential tool for the yearly surveillance of circulating virus strains and to ensure accurate clinical diagnosis for appropriate treatment.
Laurie, Karen +3 more
core +1 more source
Expression of Smad3 and Smad2 in MDCK cells.
, 2016 Immunoblotting showed that the phosphorylated Smad3 (p-Smad3) level and the ratio of p-Smad3 to Smad3 were significantly decreased in the MDCK cells treated with TGF-β1 and AAT compared to that in MDCK cells treated with TGF-β1 alone (A to D).
Hye-Myung Ryu (3110241) +10 more
core +1 more source