Results 81 to 90 of about 33,848 (196)

Exploration of the protective mechanisms of Icariin against cisplatin-induced renal cell damage in canines

Frontiers in Veterinary Science
This study delves into the protective mechanisms of Icariin (ICA) against cisplatin-induced damage in Madin-Darby canine kidney (MDCK) cells. Comprising two distinct phases, the investigation initially employed a single-factor randomized design to ...
Jiayi Liu, Liuwei Xie, He Zhai, Dongwei Wang, Xiao Li, Yao Wang, Mingqiang Song, Chao Xu   +7 more
doaj   +1 more source

LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-β peptide in a blood–brain barrier in vitro model

Neurobiology of Disease, 2008
The pathogenesis of Alzheimer’s disease is characterized by aggregation of the amyloid-β protein (Aβ) into neurotoxic plaques. Recent in vivo studies have suggested the non-proteolytic clearance of Aβ via receptor-mediated transport across the blood ...
Babak Nazer, Soyon Hong, Dennis J. Selkoe   +2 more
doaj   +1 more source

Covalently Immobilized Lignin–Xanthene Conjugates for Persistent Surface Photochemistry and Self‐Sterilizing Interfaces Under Ambient Visible Light

Macromolecular Rapid Communications, Volume 47, Issue 15, 4 August 2026.
Bio‐derived lignin–Eosin Y macromolecular networks are developed as visible‐light‐responsive self‐sterilizing coatings that generate reactive oxygen species without leaching. The spray‐coated photopolymerized surfaces exhibit durable antibacterial and antiviral activity under ambient light for extended periods, demonstrating a scalable and sustainable ...
Euna Oh, Surjith Kumaran, Sumin Han, Kiseok Lee, Hyerin Shin, Seokmin Oh, Dae‐Hong Ko, Hyo‐Jick Choi   +7 more
wiley   +1 more source

Stability of vaccine strains of seasonal live attenuated influenza vaccines when adapted to MDCK cell culture

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Currently, the vast majority of influenza vaccines in the world are produced using developing chicken embryos as substrate, but there is an urgent necessity for transferring vaccine production to continuous cell lines, which would ensure ...
Victoria A. Matyushenko, Arina D. Kostromitina, Ekaterina A. Stepanova, Larisa G. Rudenko, Irina N. Isakova-Sivak   +4 more
doaj   +1 more source

The Pharmacology of the SLC15A4‐TASL Complex, an Emerging Target for the Treatment of Lupus

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT SLC15A4 is a member of the solute carrier superfamily that has been strongly linked to the pathogenesis of the auto‐immune disease SLE. The endo‐lysosomally localized SLC15A4 has traditionally been considered a proton‐dependent histidine and peptide transporter, but has also been shown to facilitate TLR7, 8, and 9 induced IFN‐alpha signaling ...
Alex L. Wilkinson, Dillon Popat, Kathy Sengmany, Miguel C. Silva, Steven J. Charlton, Charles S. Lay   +5 more
wiley   +1 more source

Cellular Aggregation Facilitates Anoikis in MDCK Cells

The Journal of Physiological Sciences, 2008
Anoikis is a specific type of apoptosis caused by the detachment of anchorage-dependent cells from their supportive matrix. Aggregation of suspended cells is believed to suppress anoikis. Here we describe the effects of cellular aggregation on anoikis in Madin-Darby canine kidney (MDCK) cells.
openaire   +3 more sources

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, Volume 7, Issue 4, August 2026.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

Counteracting Influenza Virus Evolution Through the Full Spectrum of Broadly Protective Antibodies

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Despite the presence of licensed vaccines and therapeutics, influenza viruses remain a major public health concern, as they cause seasonal respiratory infections and pose a pandemic threat through the emergence of zoonotic strains. Although neutralizing antibodies elicited by seasonal vaccination constitute a primary defense against infection,
Yu Adachi, Yoshimasa Takahashi
wiley   +1 more source

Mesenchymal Stromal Cells Accelerate Epithelial Tight Junction Assembly via the AMP-Activated Protein Kinase Pathway, Independently of Liver Kinase B1

Stem Cells International, 2017
Background. Mesenchymal stromal cells (MSC) are fibroblast-like multipotent cells capable of tissue-repair properties. Given the essentiality of tight junctions (TJ) in epithelial integrity, we hypothesized that MSC modulate TJ formation, via the AMP ...
P. Rowart, P. Erpicum, J.-M. Krzesinski, M. Sebbagh, F. Jouret   +4 more
doaj   +1 more source

ИСПОЛЬЗОВАНИЕ ПЕРЕВИВАЕМОЙ КУЛЬТУРЫ КЛЕТОК MDCK ДЛЯ ВЫДЕЛЕНИЯ ВИРУСА ГРИППА ПТИЦ

Ветеринарная патология, 2006
The technique of avian influenza virus isolation from samples of pathological material in the MDCK(Madin Darby canine cidney) cell culture was developed. The nineteen suspensions of organs were investigated.

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