Results 81 to 90 of about 41,345 (224)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Glycosphingolipid synthesis is essential for MDCK cell differentiation

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2012
Glycosphingolipids (GSLs), which are highly concentrated at the apical membrane of polarized epithelial cells, are key components of cell membranes and are involved in a large number of processes. Here, we investigated the ability of hypertonicity (high salt medium) to induce Madin-Darby Canine Kidney (MDCK) cell differentiation and found an increase ...
Pescio, Lucila Gisele, Favale, Nicolas Octavio, Marquez, Maria Gabriela, Sterin, Norma Beatriz   +3 more
openaire   +3 more sources

ATA and AH protect MDCK cells from influenza A infection.

, 2013
Uninfected MDCK cells, or MDCK cells infected with influenza A strains were treated with either ATA alone, AH alone, or in combinations at concentrations indicated.
Anwar M. Hashem (281354), Aaron Farnsworth (247644), Runtao He (80802), Xuguang Li (103076), Anathea S. Flaman (247649), Earl G. Brown (182026), Gary Van Domselaar (5815)   +6 more
core   +1 more source

Higher titers of some H5N1 and recent human H1N1 and H3N2 influenza viruses in Mv1 Lu vs. MDCK cells

Virology Journal, 2011
Background The infectivity of influenza A viruses can differ among the various primary cells and continuous cell lines used for such measurements. Over many years, we observed that all things equal, the cytopathic effects caused by influenza A subtype ...
Daniels Deirdre E, Morrissey Jane M, O'Dowd Maureen K, Wahlgren Brett T, Wyatt Diane E, Hamilton Sara B, Lednicky John A   +6 more
doaj   +1 more source

Protein and Peptide Inhibitors of Mineralization: A Systematic Review of In Vitro Studies

Journal of Peptide Science, Volume 32, Issue 7, July 2026.
In vitro evidence from crystallization assays demonstrates that peptides inhibit mineral nucleation and crystal growth through sequence‐dependent interactions (acidic residues and phosphorylation) with mineral surfaces. In cell cultures, these molecules reduce calcium deposition and ALP activity and modulate the expression of biomineralization‐related ...
Alberto Mimila‐Cortes, Lucia Méndez‐Sánchez, Luis Fernando Ramírez‐González, Lia Hoz‐Rodríguez, Maricela Santana‐Vázquez, Karen Ivette Castro‐López, Higinio Arzate, Gonzalo Montoya‐Ayala   +7 more
wiley   +1 more source

Influenza entry pathways in polarized MDCK cells

Biochemical and Biophysical Research Communications, 2014
In non-polarized cell culture models, influenza virus has been shown to enter host cells via multiple endocytic pathways, including classical clathrin-mediated endocytic routes (CME), clathrin- and caveolae-independent routes and macropinocytosis. However, little is known about the entry route of influenza virus in differentiated epithelia, in vivo ...
Zhang, Yueting, Whittaker, Gary R.
openaire   +2 more sources

Stx16-depleted MDCK monolayer show decreased transepithelial resistance (TER).

, 2013
(A) Immunofluorescence staining for Stx16 expression in src-shRNA-MDCK and shStx16-MDCK cells. (B) Western blotting of Stx16 expression in src-shRNA-MDCK and shStx16-MDCK cells. (C) Quantitation of band densities from B. Values represent relative protein
Fang Lin (128232), Shivangi M. Inamdar (139626), Amit Choudhury (139632), Ajit Tiwari (91167), Ding Ye (405963), Jae-Joon Jung (139625)   +5 more
core   +1 more source

HUVEC and MDCK attention maps with increasing training epoch.

, 2022
The attention maps for (A-C) the standard HUVEC cell system and (A’-C’) the standard MDCK cell system are shown, as (left to right) the number of training epochs is increased from 10 epochs, to 100 epochs, and finally to the fully trained system.
Kevin Suh (12469198), Daniel J. Cohen (259554), Jens Clausen (8414202), Julienne LaChance (9915380)   +3 more
core   +1 more source

Production, Passaging Stability, and Histological Analysis of Madin–Darby Canine Kidney Cells Cultured in a Low-Serum Medium

Vaccines
Madin–Darby canine kidney (MDCK) cells are commonly used to produce cell-based influenza vaccines. However, the role of the low-serum medium on the proliferation of MDCK cells and the propagation of the influenza virus has not been well studied.
Ming Cai, Yang Le, Zheng Gong, Tianbao Dong, Bo Liu, Minne Su, Xuedan Li, Feixia Peng, Qingda Li, Xuanxuan Nian, Hao Yu, Zheng Wu, Zhegang Zhang, Jiayou Zhang   +13 more
doaj   +1 more source

Expression Profile of Drug and Nutrient Absorption Related Genes in Madin-Darby Canine Kidney (MDCK) Cells Grown under Differentiation Conditions

Pharmaceutics, 2012
The expression levels of genes involved in drug and nutrient absorption were evaluated in the Madin-Darby Canine Kidney (MDCK) <em>in vitro</em> drug absorption model.
Balvinder S. Vig, Ronald L. Smith, Teresa N. Faria, Doris A. Wall, Aiqing He, Charles A. Tilford, Yisheng Jin, Yong Quan   +7 more
doaj   +1 more source