Results 51 to 60 of about 33,185 (190)

Inhibition of influenza virus infection by garlic oil and juice in cell culture

JSFA reports, EarlyView.
Abstract Background Influenza virus infections are a significant global health and economic burden. Garlic (Allium sativum) has been proposed to have antimicrobial properties. Raw garlic consumption has been widely advocated on the internet to fight influenza by many public health agencies, information of which is easily accessible by the public. There
Carla Breen, Timothy Smith, Nick Diamantopoulos, Julie McAuley   +3 more
wiley   +1 more source

Tumorigenicity decrease in Bcl-xL deficient MDCK cells ensuring the safety for influenza vaccine production.

PLoS ONE
Madin-Darby canine kidney (MDCK) cells are the recognized cell strain for influenza vaccine production. However, the tumorigenic potential of MDCK cells raises concerns about their use in biological product manufacturing.
Jiahao Zheng, Boran Li, Lanxin Jia, Jiayou Zhang, Zheng Gong, Yang Le, Xuanxuan Nian, Xuedan Li, Bo Liu, Daiguan Yu, Zhegang Zhang, Changgui Li   +11 more
doaj   +1 more source

Toward Dynamic Liquid Cell Scaffold: Photoreversible Ion Gels Exhibiting Light‐Induced Sol‐Gel Transitions

Macromolecular Rapid Communications, EarlyView.
Light‐programmable, non‐cytotoxic ion gels based on ABC triblock copolymers undergo photoreversible sol‐gel transitions, crossing the rheological boundary (tan δ ∼ 1). UV–vis light irradiation modulates the lifetime of reversible junctions, switching the scaffold between liquid‐like and solid (gel)‐like states.
Aya Saruwatari, Yuji Kamiyama, Ryota Tamate, Jun Nakanishi, Takeshi Ueki   +4 more
wiley   +1 more source

Evaluation of near infrared dyes as markers of P-glycoprotein activity in tumors

Frontiers in Pharmacology, 2016
Aim: The multidrug resistance protein 1 (MDR1; P-glycoprotein) has been associated with efflux of chemotherapeutic agents from tumor cells and poor patient prognosis.
Inessa Semenenko, Emma Portnoy, Mohammed AbouKaoud, Serge Guzy, Serge Guzy, Miri Shmuel, Gal Itzhak, Sara Eyal   +7 more
doaj   +1 more source

Features 2016–2018 current human influenza A(H3N2) viruses circulating in Russia

Инфекция и иммунитет, 2020
Influenza A(H3N2) viruses demonstrate the highest level of evolutionary variability compared to other influenza viruses circulating in human population.
P. A. Petrova, N. I. Konovalova, A. D. Vassilieva, E. M. Eropkina, A. A. Ivanova, A. B. Komissarov, M. Yu. Eropkin, D. M. Danilenko   +7 more
doaj   +1 more source

Cellular Aggregation Facilitates Anoikis in MDCK Cells

The Journal of Physiological Sciences, 2008
Anoikis is a specific type of apoptosis caused by the detachment of anchorage-dependent cells from their supportive matrix. Aggregation of suspended cells is believed to suppress anoikis. Here we describe the effects of cellular aggregation on anoikis in Madin-Darby canine kidney (MDCK) cells.
openaire   +3 more sources

Amino Acids Regulate Transgene Expression in MDCK Cells

PLoS ONE, 2014
Gene expression and cell growth rely on the intracellular concentration of amino acids, which in metazoans depends on extracellular amino acid availability and transmembrane transport. To investigate the impact of extracellular amino acid concentrations on the expression of a concentrative amino acid transporter, we overexpressed the main kidney ...
Torrente M., Guetg A., Sass J., Arps L., Ruckstuhl L., Camargo S.M., Verrey F.   +6 more
openaire   +6 more sources

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

Cellular Signalling Networks in High Altitude Pulmonary Hypertension: From Canonical Pathways to Emerging Targets

Cell Proliferation, EarlyView.
This review elucidates the intricate cellular signalling networks involved in high‐altitude pulmonary hypertension (HAPH), integrating canonical pathways like HIF, MAPK and BMP with emerging targets such as Wnt/β‐catenin, Notch, Hippo‐YAP and IL‐6. It highlights potential therapeutic strategies targeting these pathways to mitigate vascular remodelling ...
Sheng Ding, Ju Chen, Zhaoyang Li, Yang Yu, Weijie Wang, Yan Liao, Jin Yang, Dianxiang Lu, Yujiang Fan   +8 more
wiley   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source