Results 51 to 60 of about 41,345 (224)

Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication

Advanced Science, EarlyView.
NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan, Chenyang Yuan, Zekun Meng, Yanan Wang, Xueying Zhai, Chunjie Huang, Xiang Zhou, Gaiping Zhang   +7 more
wiley   +1 more source

Shear-induced Volume Decrease in MDCK Cells [PDF]

Cellular Physiology and Biochemistry, 2012
Using a microfluidic cell volume sensor we measured the change in the cell volume of Madin-Darby Canine Kidney (MDCK) cells induced by shear stress. An increase in shear stress from 0.2 to 2.0 dyn/cm(2) resulted in a volume decrease to a steady state volume ∼ 20 - 30 % smaller than the initial resting cell volume.
Jinseok, Heo, Frederick, Sachs, Jianbin, Wang, Susan Z, Hua   +3 more
openaire   +2 more sources

Recruitment of Lyn from endomembranes to the plasma membrane through calcium-dependent cell-cell interactions upon polarization of inducible Lyn-expressing MDCK cells

Scientific Reports, 2017
Src-family kinases, expressed in a wide variety of cell types, are anchored to cellular membranes through posttranslational lipid modifications and involved in diverse cellular signalling.
Takao Morinaga, Sayuri Yanase, Aya Okamoto, Noritaka Yamaguchi, Naoto Yamaguchi   +4 more
doaj   +1 more source

Imaging‐Guided Live Single‐Cell Lipid Profiling of Leader and Follower Cellsduring Collective Migration of Triple‐Negative Breast Cancer Cells

Advanced Science, EarlyView.
Integrated single‐cell mass spectrometry reveals distinct lipidomic signatures that differentiate leader and follower phenotypes in migratory breast cancer cells. Phenotype‐specific alterations across various lipid classes, including fatty acids and phosphatidylcholines, underpin functional heterogeneity.
Xiaoyue Huang, Judit González Riera, Mai Nguyen, Jeremy Broekhuis, Sylvia E. Le Dévédec, Ahmed Ali, Thomas Hankemeier   +6 more
wiley   +1 more source

AQP5 expression in MDCK cells.

, 2015
(A-B) Epifluorescent images show the subcellular localization of AQP5 in live MDCK cells. Fluorescence is shown in inverted contrast. (A) Untreated MDCK AQP5-EGFP cells. (B) Untreated MDCK AQP5-myc-EGFP cells labeled with QDs.
Saw Marlar (776231), Lene N. Nejsum (460018), Jennifer S. Koffman (776230), Eva C. Arnspang (118878)   +3 more
core   +1 more source

Effect of human activated NRAS on replication of delNS1 H5N1 influenza virus in MDCK cells

Virology Journal, 2011
Background RAS, coded by ras proto-oncogenes, played an important role in signal transmission to regulate cell growth and differentiation. Host activation of RAS was significant for IFN-sensitive vaccinia virus (delE3L) or attenuate influenza virus in ...
Zou Wei, Zhou HongBo, Zhu Jiping, Jin MeiLin   +3 more
doaj   +1 more source

Evidence for a prepore stage in the action of Clostridium perfringens epsilon toxin. [PDF]

PLoS ONE, 2011
Clostridium perfringens epsilon toxin (ETX) rapidly kills MDCK II cells at 37°C, but not 4°C. The current study shows that, in MDCK II cells, ETX binds and forms an oligomeric complex equally well at 37°C and 4°C but only forms a pore at 37°C.
Susan L Robertson, Jihong Li, Francisco A Uzal, Bruce A McClane   +3 more
doaj   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Real‐Time and Non‐Invasive Detection of Respiratory Viral Infections Using an Intelligent Odor Monitoring System (IOMS)

Advanced Science, EarlyView.
An intelligent odor monitoring system integrates an IVC animal model, gas sensor array, real‐time resistance readout, and machine‐learning analysis to continuously monitor infection‐associated odor changes. The platform captures longitudinal sensor responses, distinguishes infected from healthy states, and supports early‐stage respiratory viral ...
Yajie Shen, Weifeng Yuan, Long Li, Yucheng Zheng, Kenan Liu, Hegeng Li, Hua‐Yao Li, Yongliang Zhao, Binzhou Ying, Lanpeng Guo, Wenjian Zhang, Shu‐Ming Kuo, Zirui Zhang, Yufan Deng, Bohan Yin, Zhaocheng Luo, Ke Xu, Huan Liu   +17 more
wiley   +1 more source

GFP expression after infection with L194AY195F-GFP and GFP-H1 in MDCK and DC-SIGN-expressing MDCK cells.

, 2013
MDCK and MDCK DC-SIGN cells were inoculated with influenza viruses GFP-H1 (A) and L194AY195F-GFP-H1 (B) at a MOI of 0.01 (solid lines). Both viruses were passaged in MDCK-DC-SIGN cells two or three times as indicated.
Gerrie de Mutsert (281417), Guus F. Rimmelzwaan (50630), Marine L. B. Hillaire (281414), Stella E. Vogelzang-van Trierum (281418), Nella J. Nieuwkoop (281415), Adrianus C. M. Boon (281416), Albert D. M. E. Osterhaus (138961), Ron A. M. Fouchier (169412)   +7 more
core   +1 more source