Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex
Cell Death and Disease, 2022 Midkine (MDK), a secreted growth factor, regulates signal transduction and cancer progression by interacting with receptors, and it can be internalized into the cytoplasm by endocytosis. However, its intracellular function and signaling regulation remain
Tian Xia +11 more
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Journal of Neuroinflammation, 2020 Background Midkine (MK) is a multifunctional cytokine found upregulated in the brain in the presence of different disorders characterized by neuroinflammation, including neurodegenerative disorders and ischemia.
Seiya Takada +8 more
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Midkine Increases Diagnostic Yield in AFP Negative and NASH-Related Hepatocellular Carcinoma.
PLoS ONE, 2016 UnlabelledRobust biomarkers for population-level hepatocellular carcinoma (HCC) surveillance are lacking. We compared serum midkine (MDK), dickkopf-1 (DKK1), osteopontin (OPN) and AFP for HCC diagnosis in 86 HCC patients matched to 86 cirrhotics, 86 with
Roslyn Vongsuvanh +5 more
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The role of midkine in health and disease
Frontiers in Immunology, 2023 Midkine (MDK) is a neurotrophic growth factor highly expressed during embryogenesis with important functions related to growth, proliferation, survival, migration, angiogenesis, reproduction, and repair.
Emely Elisa Neumaier +2 more
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Metabolic reprogramming of arachidonic acid in clear cell renal carcinoma promotes an immunosuppressive microenvironment by activating MDK signaling pathway. [PDF]
Clin Exp MedYao J, Xu T, Wang C, Xie J, Jiang Q.
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The Growth Factor Midkine Antagonizes VEGF Signaling In Vitro and In Vivo
Neoplasia: An International Journal for Oncology Research, 2008 Midkine (MDK) is a heparin-binding growth factor involved in growth, survival, migration, and differentiation of various target cells and dysregulation of MDK signaling is implicated in a variety of inflammatory diseases and cancers.
Edward Htun van der Horst +8 more
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Agronomy, 2021 Apple replant disease (ARD) impacts the economic yield of orchards by physiological and morphological suppression of apple trees on replanted soils. The complexity of replant disease caused by a plethora of biological interactions and physical properties
Ulrike Cavael +5 more
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Midkine and Pleiotrophin Concentrations in Amniotic Fluid in Healthy and Complicated Pregnancies. [PDF]
PLoS ONE, 2016 Midkine (MDK) and pleiotrophin (PTN) are heparin-binding growth factors that, in rodents, are highly expressed in early life and decrease to undetectable levels by adulthood.
Youn Hee Jee +7 more
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USP12 promotes breast cancer angiogenesis by maintaining midkine stability
Cell Death and Disease, 2021 Deubiquitinases (DUBs) have important biological functions, but their roles in breast cancer metastasis are not completely clear. In this study, through screening a series of DUBs related to breast cancer distant metastasis-free survival (DMFS) in the ...
Bin Sheng +4 more
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The Drosophila midkine/pleiotrophin homologues Miple1 and Miple2 affect adult lifespan but are dispensable for alk signaling during embryonic gut formation. [PDF]
PLoS ONE, 2014 Midkine (MDK) and Pleiotrophin (PTN) are small heparin-binding cytokines with closely related structures. The Drosophila genome harbours two genes encoding members of the MDK/PTN family of proteins, known as miple1 and miple2.
Fredrik Hugosson +5 more
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