Results 191 to 200 of about 692,269 (276)

MDM2 degraders for Merkel cell carcinoma: round peg in a round hole. [PDF]

J Clin Invest
Abdulkadir SA.
europepmc   +1 more source

Protective Effects of Nongxiang‐Type Tieguanyin on the Liver of D‐Galactose‐Induced Aging C57BL/6 Mice via the NF‐κB Signaling Pathway

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
Mechanistic diagram of the hepatoprotective effect of Tgy‐N on D‐gal‐induced senescent C57BL/6 mice (“→” indicates activation, and “⊣” indicates inhibition). ABSTRACT This research aimed to investigate the hepatoprotective and anti‐senescence effects of Nongxiang‐type Tieguanyin (Tgy‐N) on D‐galactose (D‐gal)‐induced aging C57BL/6 mice and to elucidate
Weihong Chen, Mingmei Li, Lingxiao Ye, Dongqin Huang, Jianjia Xiao, Yuchao Sang, Zizhen Wang, Jiehong Yang, Chengyong He, Jiabin Chen, Zhenghong Zuo, Xintan Chen   +11 more
wiley   +1 more source

Proteome-wide target profiling of α-helix mimetics. [PDF]

RSC Chem Biol
Date A, Wall A, Kiely-Collins H, Flack T, Houghton JW, Lu J, Thomas AM, Zhang P, Wilson AJ, Tate EW, Barnard A.   +10 more
europepmc   +1 more source

Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights

Health Care Science, Volume 5, Issue 5, Page 495-513, October 2026.
This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying, Zhengyuan Fang, Cheng Zhang, Xu Liu, Jianzhi Cui, Zezhi Li, Jiayin Tang   +6 more
wiley   +1 more source

Opportunities in cancer gene therapy: inhibiting MDM2 and restoring p14ARF as a means to activate p53. [PDF]

Mol Cell Biochem
de Oliveira SB, Alves ALV, Niitsuma BN, Antunes F, Marinho GB, Amanatidis GL, Luz J, Barbosa M, Zambotti PEO, Rodrigues OA, Strauss BE.   +10 more
europepmc   +1 more source

Human biomarker navigator

iMeta, Volume 5, Issue 5, October 2026.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Multi‐omics–driven precision medicine

iMeta, Volume 5, Issue 5, October 2026.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

E3 ubiquitin ligases orchestrate chemo-resistance in gastrointestinal malignancies: from DNA damage response to therapeutic targeting. [PDF]

Front Oncol
Ma T, Zhou Y, Li X, Guan J.
europepmc   +1 more source

Synergistic targeting of malignant pleural mesothelioma cells by MDM2 inhibitors and TRAIL agonists. [PDF]

Oncotarget, 2017
Urso L, Cavallari I, Silic-Benussi M, Biasini L, Zago G, Calabrese F, Conte PF, Ciminale V, Pasello G.   +8 more
europepmc   +1 more source

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Skeletal muscle aging is driven by coordinated local breakdown across myofibers, stem and stromal cells, immune and vascular compartments, and neuromuscular control. These mechanisms promote mitochondrial dysfunction, inflammation, senescence, impaired regeneration, fibrosis, myosteatosis, denervation, and functional decline.
Ting Liu, Yaomin Hu
wiley   +1 more source