Results 181 to 190 of about 692,269 (276)

Nanoprobe‐Enabled Precision Imaging and Panoramic Boundary Delineation in Retinoblastoma

Cancer Innovation, Volume 5, Issue 5, October 2026.
This review highlights that nanoprobe‐enabled multimodal imaging, combined with targeted probe design and AI‐assisted analysis, significantly enhances the precise visualization and boundary delineation of retinoblastoma. It further outlines key challenges and directions for translating high‐performance imaging nanoprobes into clinical practice.
Xuefei He, Precious Amarachi Ikwuagwu, Wenjing Pang, Aomen Chen, Lingchao Xiang, Feng Chen, Chen Xu, Aiguo Wu   +7 more
wiley   +1 more source

Impact of p53 Target Genes on Drug Resistance in TP53‐Mutated B‐Cell Precursor Acute Lymphoblastic Leukemia

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT TP53 mutations are linked to poor prognoses in B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL), indicating that specific p53 target genes may contribute to drug resistance. Although the impact of specific genetic alterations on drug sensitivity has been reported in BCP‐ALL, the effects of TP53 mutations on sensitivity to individual ...
Thao T. T. Nguyen, Minori Tamai, Koshi Akahane, Chiaki Komatsu, Keiko Kagami, Xuekang Qi, Luay Aswad, Kunio Miyake, Shin Kasai, Shinpei Somazu, Atsushi Watanabe, Kumiko Goi, Koichi Oshima, Hiroshi Imanaga, Yuichiro Semba, Masashi Sanada, Janne Lehtiö, Hiroaki Goto, Masayoshi Minegishi, Toshiya Inaba, Shotaro Iwamoto, Takahiro Maeda, Rozbeh Jafari, Takeshi Inukai   +23 more
wiley   +1 more source

A CEBPB/IL-1β/TNF-α feedback loop drives drug resistance to venetoclax and MDM2 inhibitors in monocytic leukemia.

Blood
Allen B, Bottomly D, Köhnke T, Wang A, Lin HY, Johnson K, Kenna I, Streltsova A, Martin E, Chen R, Savoy L, Long N, Ryabinin P, Kurtz SE, Eide CA, Carlos A, Kaempf A, Liu T, Tognon C, Searles R, Piehowski PD, Gosline SJC, Agarwal A, Chang BH, Barton M, Druker BJ, McWeeney SK, Majeti R, Tyner JW, Zhang H.   +29 more
europepmc   +1 more source

Coordinated TNF–NF‐κB and PI3K–Akt Modulation by Yueju Pill in Hashimoto's Thyroiditis: A Network Pharmacology and Molecular Docking Study

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Network pharmacology and molecular docking identify a coordinated dual‐axis regulatory framework for Yueju pill in Hashimoto's thyroiditis. Candidate compounds and prioritized targets converge on TNF–NF‐κB inflammatory and PI3K–Akt survival/apoptosis signaling, providing computational support for a testable multi‐target hypothesis requiring ...
Hao Zhang, Kuojun Ren, Shengying Wang
wiley   +1 more source

Phytochemistry, Pharmacological Potential, and Future Prospects of Abietane‐Type Diterpenoids From Salvia rosmarinus

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
The review delves into the findings on abietane diterpenes from Salvia rosmarinus. It comprises the phytochemistry, biological activities, biosynthesis, degradation studies, semisynthesis, and pharmacokinetic studies of these compounds. The potential of these compounds for future development has also been highlighted.
Rida Siddiqui, Vipin Singh, Kapil Dev
wiley   +1 more source

Mapping Mutations and Signaling Network Interactions to Guide Precision Therapy in Gallbladder Cancer

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Gallbladder cancer (GBC) is a biologically complex malignancy arising from the epithelial lining of the gallbladder, with adenocarcinoma constituting the major histological subtype. Early detection is challenging because of vague clinical manifestations and the organ's deep‐seated anatomical location, resulting in diagnosis at ...
Nisha Manav, Akanksha Kashyap, Lakshay Malhotra, Chethan Rajegowda, Chandra Prakash Prasad   +4 more
wiley   +1 more source

TP53 mutant cell lines selected for resistance to MDM2 inhibitors retain growth inhibition by MAPK pathway inhibitors but a reduced apoptotic response. [PDF]

Cancer Cell Int, 2019
Wu CE, Koay TS, Ho YH, Lovat P, Lunec J.
europepmc   +1 more source

Recalibrating the apoptotic threshold: Ubiquitin‐regulated ER stress signalling in colorectal cancer

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Ubiquitin‐dependent turnover of ER‐stress sensors, proteostasis factors, and apoptotic regulators can recalibrate the apoptotic threshold in colorectal cancer, balancing adaptive survival against terminal cell death. Defining these context‐dependent vulnerabilities may enable strategies that overcome stress adaptation and restore apoptotic competence ...
Jing Hu, Shanliang Zheng, Ying Hu
wiley   +1 more source

Brightline-1: When a Negative Trial Reveals Two Active Therapies. [PDF]

Clin Cancer Res
Shahnam A, Gounder MM.
europepmc   +1 more source

Selection on PER2 Phosphorylation Regulation Underlies Atypical Mammalian Circadian Rhythms

Ecology and Evolution, Volume 16, Issue 10, October 2026.
1. Positive selection on PER2 phosphorylation regulators in atypical circadian mammals. 2. Dolphin CSNK1E enhances PER2 phosphorylation at the stabilizing S662 site and extends PER2 half‐life. 3. Dolphin CSNK1E increases locomotor activity and reduces sleep in zebrafish.
Yujie Chong, Qingqing Liu, Haojia Jiang, Linxue Tan, Huan Chen, Wenhua Ren, Shixia Xu, Guang Yang, Daiqing Yin   +8 more
wiley   +1 more source