Results 181 to 190 of about 644,957 (254)

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, Volume 293, Issue 18, Page 5481-5513, September 2026.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Proteome-wide target profiling of α-helix mimetics. [PDF]

RSC Chem Biol
Date A, Wall A, Kiely-Collins H, Flack T, Houghton JW, Lu J, Thomas AM, Zhang P, Wilson AJ, Tate EW, Barnard A.   +10 more
europepmc   +1 more source

Medicinal and Crop Protection Chemistry: Breaking Barriers, Building Synergies

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A unified view of medicinal and crop protection chemistry reveals shared scientific progress, common challenges, and new opportunities for cross‐disciplinary collaboration. Bridging expertise across both fields could accelerate innovation and actively encourage more sustainable solutions.
Giulia Cazzaniga, Giusy L. Fratello, Alexander T. Apostle, Roberto Orru, David M. Barber, Silvia Gazzola   +5 more
wiley   +1 more source

E3 ubiquitin ligases orchestrate chemo-resistance in gastrointestinal malignancies: from DNA damage response to therapeutic targeting. [PDF]

Front Oncol
Ma T, Zhou Y, Li X, Guan J.
europepmc   +1 more source

p53 Pathway-Targeted Therapeutic Strategies in Glioblastoma: A CNS-Specific Framework Integrating Therapeutic Resistance, Molecular Stratification, CNS Pharmacology, and Clinical Translation. [PDF]

Drug Des Devel Ther
Bu F, Zeng S, Ma C, Zhang M.
europepmc   +1 more source

TP53 mutant cell lines selected for resistance to MDM2 inhibitors retain growth inhibition by MAPK pathway inhibitors but a reduced apoptotic response. [PDF]

Cancer Cell Int, 2019
Wu CE, Koay TS, Ho YH, Lovat P, Lunec J.
europepmc   +1 more source

Recent Exploration of Right-Handed D-Sulfonyl-γ-AApeptides as Potential Tools Toward α-Helical Mimicry. [PDF]

Chempluschem
Fontaine J, Cai J.
europepmc   +1 more source

Transcriptomic Stratification Reveals an FRS2-Associated, Proliferation-Independent Phenotype in MDM2-High Sarcomas. [PDF]

Curr Oncol
Sakai T, Aiba H, Yamaguchi M, Hagiwara K, Murakami H, Kimura H.   +5 more
europepmc   +1 more source

Synergistic targeting of malignant pleural mesothelioma cells by MDM2 inhibitors and TRAIL agonists. [PDF]

Oncotarget, 2017
Urso L, Cavallari I, Silic-Benussi M, Biasini L, Zago G, Calabrese F, Conte PF, Ciminale V, Pasello G.   +8 more
europepmc   +1 more source

ATM Dependent DUSP6 Modulation of p53 Involved in Synergistic Targeting of MAPK and p53 Pathways with Trametinib and MDM2 Inhibitors in Cutaneous Melanoma. [PDF]

Cancers (Basel), 2018
Wu CE, Koay TS, Esfandiari A, Ho YH, Lovat P, Lunec J.   +5 more
europepmc   +1 more source