Results 161 to 170 of about 644,957 (254)

New Insights into Chemoresistance Mediated by Mdm2 Inhibitors: The Benefits of Targeted Therapy over Common Cytostatics. [PDF]

Biomedicines
Grigoreva T, Sagaidak A, Novikova D, Tribulovich V.   +3 more
europepmc   +1 more source

Executive Function and Epigenetic Markers in Youth Exposed to Family and Community Violence in Childhood

Developmental Psychobiology, Volume 68, Issue 5, September 2026.
ABSTRACT Although exposure to violence has been linked to executive functioning impairments, the biological mechanisms underlying this association remain unclear. This study examined CpG sites associated with executive functions in 78 young adults and their links to family (psychological and physical) and community violence during childhood. The scales
Renata Queiroz Ramos, Cosme Marcelo Furtado Passos da Silva, Adriane Feijó Evangelista, Fernanda Serpeloni, Natasha Reis Lacerda, Joviana Quintes Avanci, Simone Gonçalves de Assis   +6 more
wiley   +1 more source

Correction: Combination treatment with rucaparib (Rubraca) and MDM2 inhibitors, Nutlin-3 and RG7388, has synergistic and dose reduction potential in ovarian cancer. [PDF]

Oncotarget
Zanjirband M, Curtin N, Edmondson RJ, Lunec J.   +3 more
europepmc   +1 more source

Structural Characterization and UVB Irradiation Protective Effect of the Polysaccharide From Tremella fuciformis After Microbial Fermentation

Food Frontiers, Volume 7, Issue 5, September 2026.
ABSTRACT Tremella fuciformis is an edible mushroom rich in bioactive polysaccharides. In this study, T. fuciformis was extracted by citric acid under high temperature and high‐pressure (121°C, 0.1 MPa), followed by fermentation with Saccharomyces cerevisiae CH006 and Thermus thermophilus HB27.
Xin‐Yan He, Jun‐Qiao Wang, Yi‐Qi Lin, Sih‐Yu Chu, Wen‐Xin Wang, Xuan‐Han Xiao, Yu‐Ke Hou, Xiao‐Feng Qiu, Shao‐Ping Nie, Zhi‐Jiang Wang, Huan‐Yu Liu   +10 more
wiley   +1 more source

MDM2 Inhibitor KRT-232 [PDF]

, 2020
openaire   +1 more source

A functional prognostic model predicts progression‐free survival in patients with relapsed chronic lymphocytic leukemia treated with ibrutinib + venetoclax

HemaSphere, Volume 10, Issue 9, September 2026.
Abstract Targeted therapies have improved outcomes for patients with chronic lymphocytic leukemia (CLL); yet, not all achieve durable responses. Existing prognostic models, developed for chemoimmunotherapy, have limited predictive value for newer targeted combinations.
Johanne U. Hermansen, Weikaixin Kong, Andrea M. Brodersen, Yanping Yin, Aleksandra Urban, Idun D. Rein, Liye He, Rudi Agius, Rebecca S. Teglgaard, Juho Rousu, Christian Brieghel, Sabina Kersting, Mark‐David Levin, Hoa T. T. Tran, Mattias Mattsson, Juha Ranti, Gerrit‐Jan Veldhuis, Caspar da Cunha‐Bang, Rogier Mous, Julie Dubois, Arnon P. Kater, Jorrit M. Enserink, Carsten U. Niemann, Tero Aittokallio, Sigrid S. Skånland   +24 more
wiley   +1 more source

Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen, Jiayi Wang, Jimin Yu, Yiran Zhou, Lihai Liu, Jing Liu, Liang Wang   +6 more
wiley   +1 more source

MDM2 Inhibitor AMG-232 [PDF]

, 2020
openaire   +1 more source

Genetic Association Studies in Hepatocellular Carcinoma: Systematic Meta‐Analyses, a Comprehensive Field Synopsis, and Epidemiological Evidence

MedComm, Volume 7, Issue 9, September 2026.
Based on meta‐analyses and cumulative epidemiological evidence, the present study identifies 11 genetic variants in 11 genes that are truly associated with the risk of hepatocellular carcinoma. Our work presents a systematic synopsis, which helps elucidate the mechanisms of carcinogenesis and provides insights into the early diagnosis and novel ...
Yujin Shi, Bin Huang, Xiaohong Liu, Yalan Liu, Qinyong Hu, Tianyu Lei, Luqi Tang, Guanglin Xiao, Tingting Ning, Shengqin Yue, Jiahui He, Qilian Du, Xuanmei Li, Yixuan Zhou, Qiongfang Zhang, Chunyan Qi, Hong Ren, Hong‐Gang Ren   +17 more
wiley   +1 more source

MDM2 Inhibitor BI 907828 [PDF]

, 2020
openaire   +1 more source