Results 41 to 50 of about 22,933 (184)

Clinico-radiological Difference Section between Primary and Secondary MDR Pulmonary Tuberculosis [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: Multidrug Resistant Tuberculosis (MDR-TB) is classified into primary and secondary type depending upon history of Anti-TB drug received in past. MDR-TB generally remains undetected in newly detected TB cases as the index of suspicion is low.
Deependra Kumar Rai, Alok
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Operational challenges in diagnosing multi-drug resistant TB and initiating treatment in Andhra Pradesh, India. [PDF]

PLoS ONE, 2011
BACKGROUND: Revised National TB Control Programme (RNTCP), Andhra Pradesh, India. There is limited information on whether MDR-TB suspects are identified, undergo diagnostic assessment and are initiated on treatment according to the programme guidelines ...
Sarabjit S Chadha, B N Sharath, Kishore Reddy, Jyothi Jaju, P H Vishnu, Sreenivas Rao, Malik Parmar, Srinath Satyanarayana, Kuldeep Singh Sachdeva, Nevin Wilson, Anthony D Harries   +10 more
doaj   +1 more source

Adverse events in bedaquiline‐ and pretomanid‐based regimens for drug‐resistant tuberculosis from trial, implementation and pharmacovigilance studies

British Journal of Clinical Pharmacology, EarlyView.
Abstract The availability of safety data, particularly concerning adverse events (AEs) associated with the new shorter regimen for drug‐resistant tuberculosis (TB) containing a bedaquiline–pretomanid‐based regimen, is still limited. This systematic review aims to provide a comprehensive and updated analysis of AEs related to this new regimen by ...
Nisa Maria, Annisa Lazuardi Larasati, Indri Yuliani Hamdani, Jin‐Gun Cho, Jan‐Willem C. Alffenaar   +4 more
wiley   +1 more source

Preserved Spermatogenesis and Hormonal Function in Men Receiving a Pretomanid Regimen (BPaMZ) for Pulmonary Drug‐Resistant Tuberculosis

Clinical Pharmacology &Therapeutics, EarlyView.
Pretomanid is a component of the World Health Organization‐recommended treatment regimen for drug‐resistant tuberculosis in patients aged ≥ 14 years. While preclinical rodent studies identified testicular toxicity as a potential clinical liability at elevated doses, no corresponding effects were observed in nonhuman primates nor clinical hormone ...
Pauline Howell, Antonio Lombardi, William Brumskine, Lali Mikiashvili, Kim Boekelheide, Joanna Moreira, Alda Holsta, Matthew Betteridge, Lindsay Thompson, Angela Crook, Paul Bruinenberg, Maria Beumont, Eugene Sun, Francesca Conradie   +13 more
wiley   +1 more source

Multidrug-resistant Mycobacterium tuberculosis and associated risk factors in Oromia Region of Ethiopia

International Journal of Infectious Diseases, 2015
Objective: The aim of this study was to determine risk factors for tuberculosis (TB) caused by multidrug-resistant Mycobacterium tuberculosis (MDR-TB) in Oromia Region, Ethiopia. Methods: A 6-month case–control study was performed in 2013–14.
Girma Mulisa, Tilaye Workneh, Niguse Hordofa, Mohamed Suaudi, Gemeda Abebe, Godana Jarso   +5 more
doaj   +1 more source

Food Contamination and Safety in Nigeria: A Systematic Synthesis of Heavy Metals, Microbial Pathogens, and Health Risk Metrics

Food Safety and Health, EarlyView.
This is an infographic driver of food contaminants and health effects. ABSTRACT Food safety remains a critical challenge in Nigeria due to rapid urbanization and weak regulatory enforcement. This systematic review synthesizes empirical evidence from 2015 to 2025 to characterize food contaminant profiles and associated human health risks in Nigeria ...
Cecilia Nwadiuto Obasi, Naomi A. Mogborukor, Baridoo Donatus Dooka, Polycarp Dauda Madaki, Chiara Frazzoli, Mohamed Haddad, Orish Ebere Orisakwe   +6 more
wiley   +1 more source

Multidrug-Resistant Tuberculosis 
Outbreak among US-bound Hmong 
Refugees, Thailand, 2005

Emerging Infectious Diseases, 2008
In January 2005, tuberculosis (TB), including multidrug-resistant TB (MDR TB), was reported among Hmong refugees who were living in or had recently immigrated to the United States from a camp in Thailand.
John E. Oeltmann, Jay K. Varma, Luis Ortega, Yecai Liu, Thomas O’Rourke, Maria Cano, Theresa A. Harrington, Sean Toney, Warren Jones, Samart Karuchit, Lois Diem, Dhanida Rienthong, Jordan W. Tappero, Kashef Ijaz, Susan A. Maloney   +14 more
doaj   +1 more source

Should Dermatologists Recommend Direct‐to‐Consumer App‐Based Remote Diagnostics? An Ethical Analysis

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Dermatology patients still face barriers in accessing timely specialist care. As direct‐to‐consumer (DTC) apps for remote dermatological diagnostics proliferate, guidance is lacking. While promising efficiency and efficacy, their clinical—and ethical—legitimacy is not yet well established.
Sonja Mathes, Sebastian Seurig, Theresa Willem, Marta Dechant, Stephan Traidl, Mina Kang, Pedro Marques Pinto, Annette Binder, Tilo Biedermann, Ulf Darsow   +9 more
wiley   +1 more source