Results 11 to 20 of about 3,418 (50)

Endocrine Regulation of Extra-skeletal Organs by Bone-derived Secreted Protein and the effect of Mechanical Stimulation

Frontiers in Cell and Developmental Biology, 2021
Bone serves as the support for body and provide attachment points for the muscles. The musculoskeletal system is the basis for the human body to complete exercise.
Yuxiang Du, Lingli Zhang, Zhikun Wang, Xuan Zhao, Jun Zou   +4 more
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Recapitulation of Human Embryonic Heartbeat to Promote Differentiation of Hepatic Endoderm to Hepatoblasts

Frontiers in Bioengineering and Biotechnology, 2020
Hepatic development requires multiple sequential physicochemical environmental changes in an embryo, and human pluripotent stem cells (hPSCs) allow for the elucidation of this embryonic developmental process.
Koki Yoshimoto, Koki Yoshimoto, Koki Yoshimoto, Nicolas Minier, Jiandong Yang, Satoshi Imamura, Kaylene Stocking, Kaylene Stocking, Janmesh Patel, Janmesh Patel, Shiho Terada, Yoshikazu Hirai, Ken-ichiro Kamei, Ken-ichiro Kamei, Ken-ichiro Kamei   +14 more
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Optimal parameters for the enhancement of human osteoblast-like cell proliferation in vitro via shear stress induced by high-frequency mechanical vibration

Iberoamerican Journal of Medicine, 2021
Introduction: Biomechanical stimulation of cultured human osteoblast-like cells, which is based on controlled mechanical vibration, has been previously indicated, but the exact mechanical parameters that are effective for cells' proliferation enhancement
Nahum Rosenberg, Orit Rosenberg, Jacob Halevi Politch, Haim Abramovich   +3 more
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Mechanical stimulation promotes enthesis injury repair by mobilizing Prrx1+ cells via ciliary TGF-β signaling

eLife, 2022
Proper mechanical stimulation can improve rotator cuff enthesis injury repair. However, the underlying mechanism of mechanical stimulation promoting injury repair is still unknown. In this study, we found that Prrx1+ cell was essential for murine rotator
Han Xiao, Tao Zhang, Changjun Li, Yong Cao, Linfeng Wang, Huabin Chen, Shengcan Li, Changbiao Guan, Jianzhong Hu, Di Chen, Can Chen, Hongbin Lu   +11 more
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Low-magnitude high-frequency vibration enhanced mesenchymal stem cell recruitment in osteoporotic fracture healing through the SDF-1/CXCR4 pathway [PDF]

European Cells & Materials, 2016
Low-magnitude high-frequency vibration (LMHFV) has been proven to promote osteoporotic fracture healing. Mechanical stimulation was reported to enhance SDF-1/CXCR4 signalling in mesenchymal stem cells (MSCs).
F-Y Wei, SK Chow, K-S Leung, J Qin, A Guo, OL Yu, G Li, W-H Cheung   +7 more
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Distinct mechanisms regulating mechanical force-induced Ca2+ signals at the plasma membrane and the ER in human MSCs

eLife, 2015
It is unclear that how subcellular organelles respond to external mechanical stimuli. Here, we investigated the molecular mechanisms by which mechanical force regulates Ca2+ signaling at endoplasmic reticulum (ER) in human mesenchymal stem cells. Without
Tae-Jin Kim, Chirlmin Joo, Jihye Seong, Reza Vafabakhsh, Elliot L Botvinick, Michael W Berns, Amy E Palmer, Ning Wang, Taekjip Ha, Eric Jakobsson, Jie Sun, Yingxiao Wang   +11 more
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Tension-compression loading with chemical stimulation results in additive increases to functional properties of anatomic meniscal constructs. [PDF]

PLoS ONE, 2011
This study aimed to improve the functional properties of anatomically-shaped meniscus constructs through simultaneous tension and compression mechanical stimulation in conjunction with chemical stimulation.Scaffoldless meniscal constructs were subjected ...
Daniel J Huey, Kyriacos A Athanasiou
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DLX5 regulates the osteogenic differentiation of spinal ligaments cells derived from ossification of the posterior longitudinal ligament patients via NOTCH signaling

JOR Spine, 2023
Background Ossification of the posterior longitudinal ligaments (OPLL) is common disorder characterized by heterotopic ossification of the spinal ligaments. Mechanical stimulation (MS) plays an important role in OPLL.
Tao Tang, Zhengya Zhu, Zhongyuan He, Fuan Wang, Hongkun Chen, Shengkai Liu, Mingbin Zhan, Jianmin Wang, Wei Tian, Dafu Chen, Xinbao Wu, Xizhe Liu, Zhiyu Zhou, Shaoyu Liu   +13 more
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Robotic trunk perturbation magnitude affects standing postural responses in individuals with motor complete spinal cord injury receiving epidural stimulation

Scientific Reports
After a severe spinal cord injury (SCI), the human spinal circuitry receiving epidural stimulation can generate lower limb postural responses to sensory inputs associated with trunk perturbation.
Enrico Rejc, Collin D. Bowersock, Tanvi Pisolkar, Simone Zaccaron, Claudia A. Angeli, Gail F. Forrest, Sunil Agrawal, Susan J. Harkema   +7 more
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Modulation of interhemispheric inhibition and motor learning by different intensities of bilateral transcranial direct current stimulation in healthy adults

Scientific Reports
Interhemispheric inhibition (IHI) plays a crucial role in performing unilateral hand movements. Transcranial direct current stimulation (tDCS) has been shown to modulate IHI and enhance motor learning, but the most effective stimulation intensity remains
Thatchaya Prathum, Julien Dauguet, Irin Apiworajirawit, Benchaporn Aneksan, Siriwan Hoisan, Arruck Tragangoon, Vorasith Siripornpanich, Wanalee Klomjai   +7 more
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