Results 91 to 100 of about 7,453,208 (377)
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Study of stress corrosion in aluminum alloys [PDF]
, 1967 Mechanism of the stress corrosion cracking of high-strength aluminum alloys was investigated using electrochemical, mechanical, and electron microscopic techniques.
Brummer, S. B.
core +1 more source
How a colloidal paste flows – scaling behaviors in dispersions of aggregated particles under mechanical stress – [PDF]
, 2008 We have developed a novel computational scheme that allows direct numerical simulation of the mechanical behavior of sticky granular matter under stress.
Botet, Robert +4 more
core +1 more source
Scientific Reports, 2017 Lumbar spinal stenosis (LSS) is one of the most frequent causes of low back pain and gait disturbance in the elderly. Ligamentum flavum (LF) hypertrophy is the main pathomechanism of LSS, but the reason for its occurrence is not clearly elucidated.
Kazunori Hayashi +13 more
semanticscholar +1 more source
Epigenetic mechanisms in stress and adaptation [PDF]
Brain, Behavior, and Immunity, 2011 Epigenetic mechanisms are processes at the level of the chromatin that control the expression of genes but their role in neuro-immuno-endocrine communication is poorly understood. This review focuses on epigenetic modifications induced by a range of stressors, both physical and psychological, and examines how these variations can affect the biological ...
Mifsud, Karen R +5 more
openaire +4 more sources
On the dynamics of mechanical failures in magnetized neutron-star crusts
, 2012 We consider the dynamics of a mechanical failure induced by a shear stress in a strongly magnetized neutron-star crust. We show that even if the elastic properties of the crust allow the creation of a shear crack, the strongly sheared magnetic field ...
Ashby +21 more
core +1 more source
Under Pressure: Mechanical Stress Management in the Nucleus
Cells, 2016 Cells are constantly adjusting to the mechanical properties of their surroundings, operating a complex mechanochemical feedback, which hinges on mechanotransduction mechanisms.
Nejma Belaadi +2 more
semanticscholar +1 more source
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
Simplified method measures changes in tensile yield strength using least number of specimens [PDF]
, 1967 Simplified method determines yield strength due to heat treat, irradiation or mechanical treatment. Each specimen in a group of specimens is tested for yield stress point, subjected to heat treat or irradiation, and retested for new yield stress point ...
Dixon, C. E.
core +1 more source
Scientific Reports, 2016 Mechanical factors play a key role in regulating the development of cartilage degradation in osteoarthritis. This study aimed to identify the influence of mechanical stress in cartilage and chondrocytes.
Qiang Liu +6 more
semanticscholar +1 more source