Results 201 to 210 of about 1,725,788 (328)

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Lung adenocarcinoma cells respond differently to mechanical stress in 3D versus 2D environments. [PDF]

Commun Biol
Kitamura N, Iwatake M, Mizoguchi S, Ibrahim Wani S, Kobayashi K, Hasnain M, Nguyen VD, Yokoyama R, Kitade N, Ojima T, Shimoyama K, Koba N, Hatta H, Raredon MSB, Hirabayashi K, Morinaga Y, Tsuchiya T.   +16 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Elucidating the underlying mechanism of mechanical stress-induced impact on mRNA-LNP structure. [PDF]

Sci Rep
Jensen EL, Chi YC, Edwards R, Wang HL, Matthessen R, Goffin B, Van Hees S, Friese OV, Van Pottelberge R.   +8 more
europepmc   +1 more source

Mechanical/thermal stresses

Documentation of the thermal and mechanical stresses for the parts of the turbo-machine (rotating parts and casing).
openaire   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

In vivo mechano-tissue engineering by hydrogels capable of transmitting intercellular mechanical stress. [PDF]

Nat Commun
Ueda N, Okazaki H, Mikuma A, Kunieda A, Kawashima S, Torii T, Kawauchi K, Matsuoka M, Onodera T, Iwasaki N, Nagahama K.   +10 more
europepmc   +1 more source

Ceil Remodelling by Mechanical Stress. Signal Flow from Mechanosensation to Cell Response.

, 2000
Masahiro Sokabe
openalex   +2 more sources

Modulation of tissue growth heterogeneity by responses to mechanical stress [PDF]

, 2018
Antoine Fruleux, Arezki Boudaoud
openalex   +1 more source

Novel extended C-m models of flow stress for accurate mechanical and metallurgical calculations and comparison with traditional flow models

, 2021
Man Soo Joun, Mohd Kaswandee Razali, Jae Dong Yoo, Min Cheol Kim, Jeong Muk Choi   +4 more
openalex   +1 more source