Results 41 to 50 of about 12,217,563 (347)
Carl F. Craver and Lindley Darden: \u3cem\u3eIn Search of Mechanisms: Discoveries Across the Life Sciences\u3c/em\u3e [PDF]
, 2014 Carl Craver and Lindley Darden are two of the foremost proponents of a recent approach to the philosophy of biology that is often called the New Mechanism.
Glennan, Stuart
core +2 more sources
Ferroptosis: Emerging mechanisms, biology and hallmarks
MEDS Clinical Medicine, 2023 : Ferroptosis is a new type of cell death which is iron-dependent and caused by lipid peroxidation, distinguished from apoptosis, necrosis, pyroptosis, and autophagy.
Zixun Wang, Daowei Li
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack +39 more
wiley +1 more source
The challenges of purely mechanistic models in biology and the minimum need for a 'mechanism-plus-X' framework [PDF]
, 2018 Ever since the advent of molecular biology in the 1970s, mechanical models have become the dogma in the field, where a "true" understanding of any subject is equated to a mechanistic description. This has been to the detriment of the biomedical sciences,
Ehsani, Sepehr
core +1 more source
Methionine Restriction and Cancer Biology
Nutrients, 2020 The essential amino acid, methionine, is important for cancer cell growth and metabolism. A growing body of evidence indicates that methionine restriction inhibits cancer cell growth and may enhance the efficacy of chemotherapeutic agents.
D. Wanders, K. Hobson, X. Ji
semanticscholar +1 more source
Regulatory Mechanisms in Stem Cell Biology [PDF]
Cell, 1997 Stem cells are a subject of intense and increasing interest because of their biological properties and potential medical importance. Unfortunately, the field has been difficult for the nonspecialist to penetrate, in part because of ambiguity about what exactly constitutes a stem cell.
Morrison, Sean J. +2 more
openaire +3 more sources
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
Enhancing homology-directed repair efficiency with HDR-boosting modular ssDNA donor
Nature CommunicationsDespite the potential of small molecules and recombinant proteins to enhance the efficiency of homology-directed repair (HDR), single-stranded DNA (ssDNA) donors, as currently designed and chemically modified, remain suboptimal for precise gene editing ...
Ying-Ying Jin +12 more
doaj +1 more source
Caloric restriction, Sirtuins, and cardiovascular diseases
Chinese Medical Journal. Caloric restriction (CR) is a well-established dietary intervention known to extend healthy lifespan and exert positive effects on aging-related diseases, including cardiovascular conditions. Sirtuins, a family of nicotinamide adenine dinucleotide (NAD+
Ziyu Wei +7 more
doaj +1 more source
Nature Communications, 2020 Water intake is critical to our life, and the subfornical organ in the brain involved in the control of this behavior. Here, the authors reveal that two distinct groups of CCK-producing neurons in the SFO suppress water intake according to the ...
Takashi Matsuda +4 more
doaj +1 more source