Results 41 to 50 of about 1,496,926 (225)
Biophysical Journal, 1962 I should like to begin by saying that I feel very diffident about speaking on the subject which the organizers of this Conference invited me to discuss with you. What I have to say will inevitably be limited by the extreme superficiality of my acquaintance with modem biochemistry and biophysics.
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Introduction to Statistical Physics outside Physics [PDF]
, 2003 We review the possibilities and difficulties for statistical physicists if they apply their methods to biology, economics, or sociology.
arxiv +1 more source
CRISPR-Cas: biology, mechanisms and relevance [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2016 Prokaryotes have evolved several defence mechanisms to protect themselves from viral predators. Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated proteins (Cas) display a prokaryotic adaptive immune system that memorizes previous infections by integrating short sequences of invading genomes—termed spacers—into the ...
Frank Hille, Emmanuelle Charpentier
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Caloric restriction, Sirtuins, and cardiovascular diseases
Chinese Medical Journal. Caloric restriction (CR) is a well-established dietary intervention known to extend healthy lifespan and exert positive effects on aging-related diseases, including cardiovascular conditions. Sirtuins, a family of nicotinamide adenine dinucleotide (NAD+
Ziyu Wei +7 more
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Enhancing homology-directed repair efficiency with HDR-boosting modular ssDNA donor
Nature CommunicationsDespite the potential of small molecules and recombinant proteins to enhance the efficiency of homology-directed repair (HDR), single-stranded DNA (ssDNA) donors, as currently designed and chemically modified, remain suboptimal for precise gene editing ...
Ying-Ying Jin +12 more
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A. Sergi, Atti della Accademia Peloritana dei Pericolanti Vol.
LXXXVII, C1C0901001 (2009), 2009 A critical assessment of the recent developments of molecular biology is presented. The thesis that they do not lead to a conceptual understanding of life and biological systems is defended. Maturana and Varela's concept of autopoiesis is briefly sketched and its logical circularity avoided by postulating the existence of underlying {\it living ...
arxiv +1 more source
Application of different methods used to transfect small molecule NADPH into cells [PDF]
Jichu yixue yu linchuangObjective To compare the three different methods for direct transfection of small exogenous nicotinamide adenine dinucleotide phosphate(NADPH) into cells by a non-metabolic pathway.
LI Haoyue, DU Wenjing, LI Wei
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Adaptation using hybridized genetic crossover strategies [PDF]
Physica A 322, 701 (2003), 2002 We present a simple game which mimics the complex dynamics found in most natural and social systems. Intelligent players modify their strategies periodically, depending on their performances. We propose that the agents use hybridized one-point genetic crossover mechanism,inspired by genetic evolution in biology, to modify the strategies and replace the
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BMC Infectious DiseasesInfluenza-related acute lung injury is a life-threatening condition primarily caused by uncontrolled replication of the influenza virus and intense proinflammatory responses.
Lifang Zhang +7 more
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Vibrations, Quanta and Biology [PDF]
Contemp. Phys. 54, 181 - 207 (2013), 2013 Quantum biology is an emerging field of research that concerns itself with the experimental and theoretical exploration of non-trivial quantum phenomena in biological systems. In this tutorial overview we aim to bring out fundamental assumptions and questions in the field, identify basic design principles and develop a key underlying theme -- the ...
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