Results 131 to 140 of about 4,146,035 (404)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Mechanism of action of VP1-001 in cryAB(R120G)-associated and age-related cataracts [PDF]

, 2019
PurposeWe previously identified an oxysterol, VP1-001 (also known as compound 29), that partially restores the transparency of lenses with cataracts. To understand the mechanism of VP1-001, we tested the ability of its enantiomer, ent-VP1-001, to bind ...
Andley, Usha P., Covey, Douglas F., Dunyak, Bryan M., Gestwicki, Jason E., Hamilton, Paul D., Izrayelit, Yevgeniy, Makley, Leah N., McGlasson-Naumann, Brittney, Molnar, Kathleen S., Qian, Mingxing, Su, Bonnie   +10 more
core   +2 more sources

Possible Action of the Sex-Determining Mechanism [PDF]

, 1918
C. E. McClung
openalex   +1 more source

Competition for Procurement Shares [PDF]

We propose a new procurement procedure which allocates shares of the total amount to be procured depending on the bids of suppliers. Among the properties of the mechanism are: (i) Bidders have an incentive to participate in the procurement procedure, as ...
ALCALDE, JOSÉ, MATTHIAS, DAHM
core  

A New Approach to Non-Commutative U(N) Gauge Fields

, 2010
Based on the recently introduced model of arXiv:0912.2634 for non-commutative U(1) gauge fields, a generalized version of that action for U(N) gauge fields is put forward. In this approach to non-commutative gauge field theories, UV/IR mixing effects are
Armoni A., Attems M., Blaschke D. N., Blaschke D. N., Blaschke D. N., Blaschke D. N., Blaschke D. N., Blaschke D. N. Kronberger E. Sedmik R. I. P. Wohlgenannt M., Blaschke D. N. Rofner A. Sedmik R. I. P. Wohlgenannt M., D. N. Blaschke, Grosse H., Hayakawa M., Levell J., Matusis A., Minwalla S., Rivasseau V., Vilar L. C. Q.   +16 more
core   +1 more source

Concerning the Mechanism of Complement Action [PDF]

, 1956
Elmer L. Becker
openalex   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

STUDY OF A CASE OF DIABETES INSIPIDUS WITH SPECIAL REFERENCE TO THE MECHANISM OF THE DIURESIS AND OF THE ACTION OF PITUITARY EXTRACT ON IT [PDF]

, 1917
C. D. Christie
openalex   +1 more source

Mechanism of the Vasodilator Action of Pinacidil [PDF]

, 1990
The mechanism of the vasodilator action of pinacidil has been studied in rat mesenteric small arteries. The results show, first, that the use of flux studies to make measurements of ion permeability requires knowledge of the membrane potential ...
Aalkjoer, C, Hughes, AD, Mulvany, MJ, Videboek, LM   +3 more
core  

Mechanism of Esterase Action: Nature of the Reactive Serine Residue in Enzymes inhibited by Organo-Phosphorus Compounds [PDF]

, 1958
Gene Porter, H. N. Rydon, Jeremy A. Schofield   +2 more
openalex   +1 more source