Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration. [PDF]
, 2018 Nematode EAK-7 (enhancer-of-akt-1-7) regulates dauer formation and controls life span; however, the function of the human ortholog mammalian EAK-7 (mEAK-7) is unknown.
Fox, Alexandra Lucienne +5 more
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Targeting phosphoinositide 3-kinase (PI3K) in head and neck squamous cell carcinoma (HNSCC). [PDF]
, 2018 The landscape of head and neck squamous cell carcinoma (HNSCC) has been changing rapidly due to growing proportion of HPV-related disease and development of new therapeutic agents.
Jung, Kyungsuk +2 more
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Molecular & Cellular Oncology, 2019 Modeling renal cancer in the mouse has been challenging. We recently showed that upregulation of mechanistic target of rapamycin complex 1 (mTORC1) in a restricted segment of the renal tubule leads to downregulation of the tricarboxylic acid (TCA) cycle ...
Luca Drusian, Alessandra Boletta
doaj +1 more source
mTORC1 signaling in hepatic lipid metabolism
Protein & Cell, 2017 The mechanistic target of rapamycin (mTOR) signaling pathway regulates many metabolic and physiological processes in different organs or tissues. Dysregulation of mTOR signaling has been implicated in many human diseases including obesity, diabetes ...
Jinbo Han, Yiguo Wang
doaj +1 more source
The potential of sestrins as therapeutic targets for diabetes [PDF]
, 2015 Sestrins (Sesn1/2/3) belong to a small protein family that has versatile biological functions. In addition to initially characterized oxidoreductase activity, sestrins also have oxidoreductase-independent functions, including activation of AMP-activated ...
Dong, X. Charlie
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Convergent and Divergent Mechanisms of Epileptogenesis in mTORopathies
Frontiers in Neuroanatomy, 2021 Hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) due to mutations in genes along the PI3K-mTOR pathway and the GATOR1 complex causes a spectrum of neurodevelopmental disorders (termed mTORopathies) associated with malformation of
Lena H. Nguyen +3 more
doaj +1 more source
mTORC1 in the Paneth cell niche couples intestinal stem cell function to calorie intake [PDF]
, 2012 How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment stem-cell function in response to ...
Abdulmetin Dursun +45 more
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Repeated bouts of resistance exercise in rats alter mechanistic target of rapamycin complex 1 activity and ribosomal capacity but not muscle protein synthesis [PDF]
, 2021 Takaya Kotani +5 more
openalex +1 more source
Transplantation Reports, 2018 Chronic rejection of transplanted organs remains an unresolved issue in clinical organ transplantation. The macrophages play a crucial role in the development of chronic rejection.
Wei Chen +4 more
doaj +1 more source
Phase I dose-escalation study of the mTOR inhibitor sirolimus and the HDAC inhibitor vorinostat in patients with advanced malignancy. [PDF]
, 2016 Preclinical models suggest that histone deacetylase (HDAC) and mammalian target of rapamycin (mTOR) inhibitors have synergistic anticancer activity. We designed a phase I study to determine the safety, maximum tolerated dose (MTD), recommended phase II ...
Falchook, Gerald S. +17 more
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