Mechanism of Activation of Mechanistic Target of Rapamycin Complex 1 by Methionine [PDF]
Frontiers in Cell and Developmental Biology, 2020 Nutrients are closely involved in the regulation of lifespan and metabolic health. Cellular activities, such as the regulation of metabolism, growth, and aging, are mediated by a network of nutrients and nutrient-sensing pathways.
Munehiro Kitada +6 more
doaj +6 more sources
Mechanistic Target of Rapamycin Complex 1 Signaling Links Hypoxia to Increased IGFBP-1 Phosphorylation in Primary Human Decidualized Endometrial Stromal Cells [PDF]
Biomolecules, 2021 Insulin-like growth factor-1 (IGF-1) bioavailability in pregnancy is governed by IGF binding protein (IGFBP-1) and its phosphorylation, which enhances the affinity of IGFBP-1 for the growth factor.
Pinki Nandi +5 more
doaj +9 more sources
The mechanistic target of rapamycin complex 1 pathway involved in hepatic gluconeogenesis through peroxisome-proliferator-activated receptor γ coactivator-1α [PDF]
Animal Nutrition, 2022 Cattle can efficiently perform de novo generation of glucose through hepatic gluconeogenesis to meet post-weaning glucose demand. Substantial evidence points to cattle and non-ruminant animals being characterized by phylogenetic features in terms of ...
Guoyan Wang +8 more
doaj +5 more sources
Enhanced activation of mechanistic target of rapamycin complex 1 signaling in eruptive xanthomas [PDF]
JAAD International, 2023 Yan Huang, BS +9 more
doaj +6 more sources
The Antidiabetic Drug Lobeglitazone Protects Mice From Lipogenesis-Induced Liver Injury via Mechanistic Target of Rapamycin Complex 1 Inhibition [PDF]
Frontiers in Endocrinology, 2018 Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder closely linked with type II diabetes (T2D). The progression of NAFLD is associated with the induction of lipogenesis through hyperactivation of the mechanistic target of rapamycin complex ...
Yu Seol Lee +11 more
doaj +7 more sources
Mechanistic Target of Rapamycin Complex 1 Signaling Modulates Vascular Endothelial Function Through Reactive Oxygen Species [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background The mechanistic target of rapamycin complex 1 (mTORC1) is an important intracellular energy sensor that regulates gene expression and protein synthesis through its downstream signaling components, the S6‐kinase and the ribosomal S6 protein ...
John J. Reho +2 more
doaj +4 more sources
Effect of mechanistic/mammalian target of rapamycin complex 1 on mitochondrial dynamics during skeletal muscle hypertrophy [PDF]
Physiological Reports, 2021 Mechanistic/mammalian target of rapamycin (mTOR) is a central factor of protein synthesis signaling and plays an important role in the resistance training‐induced increase in skeletal muscle mass and subsequent skeletal muscle hypertrophy response.
Kazuki Uemichi +3 more
doaj +4 more sources
Mechanistic target of rapamycin complex 1 orchestrates the interplay between hepatocytes and Kupffer cells to determine the outcome of immune-mediated hepatitis [PDF]
Cell Death and Disease, 2022 The cell-cell interaction between hepatocytes and Kupffer cells (KCs) is crucial for maintaining liver homeostasis, and the loss of KCs and hepatocytes is known to represent a common pathogenic phenomenon in autoimmune hepatitis.
Xiaoli Sun +6 more
doaj +4 more sources
Endoplasmic reticulum stress-induced apoptosis in intestinal epithelial cells: a feed-back regulation by mechanistic target of rapamycin complex 1 (mTORC1) [PDF]
Journal of Animal Science and Biotechnology, 2018 Background Endoplasmic reticulum (ER) stress is associated with multiple pathological processes of intestinal diseases. Despite a critical role of mechanistic target of rapamycin complex 1 (mTORC1) in regulating cellular stress response, the crosstalk ...
Yun Ji +5 more
doaj +4 more sources
Mechanistic Target of Rapamycin Complex 1: From a Nutrient Sensor to a Key Regulator of Metabolism and Health. [PDF]
Adv Nutr, 2022 Mechanistic target of rapamycin complex 1 (mTORC1) is a multi-protein complex widely found in eukaryotes. It serves as a central signaling node to coordinate cell growth and metabolism by sensing diverse extracellular and intracellular inputs, including amino acid-, growth factor-, glucose-, and nucleotide-related signals.
Wang G +6 more
europepmc +5 more sources