Results 21 to 30 of about 584 (208)
Mechanistic target of rapamycin complex 1 and 2 in human temporal lobe epilepsy [PDF]
Annals of Neurology, 2018 ObjectiveTemporal lobe epilepsy (TLE) is a chronic epilepsy syndrome defined by seizures and progressive neurological disabilities, including cognitive impairments, anxiety, and depression. Here, human TLE specimens were investigated focusing on the mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) and complex 2 (mTORC2) activities in the brain,
Delia M. Talos +9 more
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mTORC1 (Mechanistic Target of Rapamycin Complex 1) Signaling in Endothelial and Smooth Muscle Cells Is Required for Vascular Function [PDF]
Hypertension, 2021 mTORC1 (Mechanistic target of rapamycin complex 1) serves as a molecular hub and intracellular energy sensor that regulate various cellular processes. Emerging evidence points to mTORC1 signaling as a critical regulator of cardiovascular function with implications for cardiovascular disease.
John J Reho +5 more
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Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1 [PDF]
Scientific Reports, 2019 AbstractInactivation of the protein complex ‘mechanistic target of rapamycin complex 1’ (mTORC1) can increase the nuclear content of transcriptional regulators of metabolism and apoptosis. Previous studies established that nuclear import of signal transducer and activator of transcription-1 (STAT1) requires the mTORC1-associated adaptor karyopherin-α1 (
Antonio Layoun +15 more
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Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1) [PDF]
Journal of Biological Chemistry, 2017 The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of protein synthesis and potential target for modifying cellular metabolism in various conditions, including cancer and aging. mTORC1 activity is tightly regulated by the availability of extracellular amino acids, and previous studies have revealed that amino acids in the ...
Shusaku Shibutani +2 more
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Advances in Nutrition, 2022 Mechanistic target of rapamycin complex 1 (mTORC1) is a multi-protein complex widely found in eukaryotes. It serves as a central signaling node to coordinate cell growth and metabolism by sensing diverse extracellular and intracellular inputs, including amino acid-, growth factor-, glucose-, and nucleotide-related signals.
Guoyan Wang +6 more
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RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells [PDF]
Cellular Signalling, 2014 The mechanistic target of rapamycin (mTOR) in complex 1 (mTORC1) pathway integrates signals generated by hormones and nutrients to control cell growth and metabolism. The activation state of mTORC1 is regulated by a variety of GTPases including Rheb and Rags.
Bradley S. Gordon +6 more
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Transcriptional and Epigenetic Regulation by the Mechanistic Target of Rapamycin Complex 1 Pathway [PDF]
Journal of Molecular Biology, 2018 Nutrient availability impacts health such that nutrient excess states can dysregulate epigenetic and transcriptional pathways to cause many diseases. Increasing evidence implicates aberrant regulation of nutrient signaling cascades as one means of communicating nutrient information to the epigenetic and transcriptional regulatory machinery.
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A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis
Molecular & Cellular Oncology, 2021 Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex 1 ...
Yuelong Yan, Guang Lei, Boyi Gan
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RhoA regulates the mechanistic target of rapamycin complex 1 (mTORC1)
The FASEB Journal, 2013 The mTORC1 signaling pathway plays a vital role in integrating signals generated by hormones and nutrients to control cell growth and metabolism. The point of integration of many of the input signals from hormones is the GTPase activating protein complex TSC1/2 that acts to repress the mTORC1‐stimulatory activity of the small GTPase Rheb.
Bradley S. Gordon +5 more
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Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP
Molecular Brain, 2023 The consolidation of learned information into long-lasting memories requires the strengthening of synaptic connections through de novo protein synthesis. Translation initiation factors play a cardinal role in gating the production of new proteins thereby
Shane Wiebe +7 more
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