Results 41 to 50 of about 66,500 (291)

Activated Protein Phosphatase 2A Disrupts Nutrient Sensing Balance Between Mechanistic Target of Rapamycin Complex 1 and Adenosine Monophosphate-Activated Protein Kinase, Causing Sarcopenia in Alcohol-Associated Liver Disease. [PDF]

Hepatology, 2021
Davuluri G, Welch N, Sekar J, Gangadhariah M, Alsabbagh Alchirazi K, Mohan ML, Kumar A, Kant S, Thapaliya S, Stine M, McMullen MR, McCullough RL, Stark GR, Nagy LE, Naga Prasad SV, Dasarathy S.   +15 more
europepmc   +3 more sources

Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1). [PDF]

J Biol Chem, 2017
The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of protein synthesis and potential target for modifying cellular metabolism in various conditions, including cancer and aging. mTORC1 activity is tightly regulated by the availability of extracellular amino acids, and previous studies have revealed that amino acids in the ...
Shibutani S, Okazaki H, Iwata H.
europepmc   +4 more sources

Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast-twitch muscle in rats. [PDF]

Physiol Rep
Uda M, Yoshihara T, Ichinoseki-Sekine N, Baba T.   +3 more
europepmc   +3 more sources

Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1. [PDF]

Sci Rep, 2019
AbstractInactivation of the protein complex ‘mechanistic target of rapamycin complex 1’ (mTORC1) can increase the nuclear content of transcriptional regulators of metabolism and apoptosis. Previous studies established that nuclear import of signal transducer and activator of transcription-1 (STAT1) requires the mTORC1-associated adaptor karyopherin-α1 (
Layoun A, Goldberg AA, Baig A, Eng M, Attias O, Nelson K, Carella A, Amberber N, Fielhaber JA, Joung KB, Schmeing TM, Han Y, Downey J, Divangahi M, Roux PP, Kristof AS.   +15 more
europepmc   +5 more sources

Prenatal Mechanistic Target of Rapamycin Complex 1 (m TORC1) Inhibition by Rapamycin Treatment of Pregnant Mice Causes Intrauterine Growth Restriction and Alters Postnatal Cardiac Growth, Morphology, and Function. [PDF]

J Am Heart Assoc, 2017
Hennig M, Fiedler S, Jux C, Thierfelder L, Drenckhahn JD.   +4 more
europepmc   +2 more sources

Mechanistic target of rapamycin complex 1 is involved in psoriasis and regulated by anti‐TNF‐α treatment [PDF]

Experimental Dermatology, 2016
The mechanistic target of rapamycin (mTOR) acts through two distinct signalling complexes, known as mTOR complex (mTORC) 1 and mTORC2. One of the main upstream regulator of mTORC1 is tumour necrosis factor (TNF)-α, an important pro-inflammatory cytokine involved in psoriasis.
Anna Balato, Serena Lembo, Fabio Ayala, Nicola Balato, Giuseppina Caiazzo, Annunziata Raimondo, Roberta Di Caprio, Giuseppe Monfrecola   +7 more
openalex   +4 more sources

Mechanistic/mammalian target of rapamycin complex 1 (mTORC1) signaling is involved in phagocytosis activation during THP-1 cell differentiation

Journal of Veterinary Medical Science, 2023
Mechanistic/mammalian target of rapamycin complex 1 (mTORC1) is a serine/threonine kinase that plays a major role in cell metabolism. Although mTORC1 inhibitors are known to exert immunosuppressive effects, their effects on immune cells are not fully understood.
Hiroka MUROKAWA, Karin Egusa, Shusaku Shibutani, Hiroyuki IWATA   +3 more
openalex   +4 more sources

Reactivation of cocaine contextual memory engages mechanistic target of rapamycin/S6 kinase 1 signaling

Frontiers in Pharmacology, 2022
Mechanistic target of rapamycin (mTOR) C1 and its downstream effectors have been implicated in synaptic plasticity and memory. Our prior work demonstrated that reactivation of cocaine memory engages a signaling pathway consisting of Akt, glycogen ...
Xiangdang Shi, Eva von Weltin, Emma Fitzsimmons, Chau Do, Carolina Caban Rivera, Chongguang Chen, Lee-Yuan Liu-Chen, Ellen M. Unterwald   +7 more
doaj   +1 more source

Long Noncoding RNA HCG18 Promotes Malignant Phenotypes of Breast Cancer Cells via the HCG18/miR-103a-3p/UBE2O/mTORC1/HIF-1α–Positive Feedback Loop

Frontiers in Cell and Developmental Biology, 2021
In recent years, an increasing number of studies have reported that long noncoding RNAs (lncRNAs) play crucial roles in breast cancer (BC) progression and metastasis. Another study group of our research center reported that lncRNA HCG18 was one of the 30
Xu Liu, Kun Qiao, Kaiyuan Zhu, Xianglan Li, Chunbo Zhao, Jiaqi Li, Dawei Feng, Yu Fang, Peng Wang, Cheng Qian, Wenbo Qiao   +10 more
doaj   +1 more source

Tuberous Sclerosis Complex 1–Mechanistic Target of Rapamycin Complex 1 Signaling Determines Brown-to-White Adipocyte Phenotypic Switch [PDF]

Diabetes, 2014
Interconversion of white and brown adipocytes occurs between anabolic and catabolic states. The molecular mechanism regulating this phenotypic switch remains largely unknown. This study explores the role of tuberous sclerosis complex 1 (TSC1)–mechanistic target of rapamycin (mTOR) signaling in the conversion of brown to white adipose tissue (WAT).
Xinxin Xiang, Lan He, Hong Tang, Fang Yuan, Yanhui Xu, Jing Zhao, Yin Li, Weizhen Zhang   +7 more
openalex   +3 more sources