Results 61 to 70 of about 66,500 (291)
Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively [PDF]
, 2017 Uncontrolled cell growth in Tuberous Sclerosis Complex occurs due to inappropriate activation of mechanistic (mammalian) target of rapamycin complex 1 (mTORC1).
Dunlop, Elaine A +4 more
core +1 more source
The FASEB Journal, 2021 We have recently reported that the chronic elevation of renal perfusion pressure (RPP) drives the infiltration of renal inflammatory cells in two models of hypertension, the Dahl salt‐sensitive (SS) rats fed a high‐salt diet and Sprague‐Dawley (SD) rats infused with Angiotensin II.
Satoshi Shimada +4 more
openaire +1 more source
Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP
Molecular Brain, 2023 The consolidation of learned information into long-lasting memories requires the strengthening of synaptic connections through de novo protein synthesis. Translation initiation factors play a cardinal role in gating the production of new proteins thereby
Shane Wiebe +7 more
doaj +1 more source
The Lancet. Healthy Longevity, 2021 Summary: COVID-19 disproportionately affects older people, with likelihood of severe complications and death mirroring that of other age-associated diseases.
Evelyne Bischof, MD +3 more
doaj +1 more source
DN200434 Inhibits Vascular Smooth Muscle Cell Proliferation and Prevents Neointima Formation in Mice after Carotid Artery Ligation [PDF]
Endocrinology and Metabolism, 2022 Background Excessive proliferation and migration of vascular smooth muscle cells (VSMCs), which contributes to the development of occlusive vascular diseases, requires elevated mitochondrial oxidative phosphorylation to meet the increased requirements ...
Sudeep Kumar +9 more
doaj +1 more source
Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells [PDF]
, 2018 Wiring metabolic signaling circuits in thymocytes Cell differentiation is often accompanied by metabolic changes. Yang et al. report that generation of double-positive (DP) thymocytes from double-negative (DN) cells coincides with dynamic regulation of ...
Awad, Walid +14 more
core +1 more source
PLoS Pathogens, 2022 Previous studies have shown that the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway has antiviral functions or is beneficial for viral replication, however, the detail mechanisms by which mTORC1 enhances viral infection remain ...
Pan-Pan Hong +4 more
doaj +1 more source
GSK3-mediated raptor phosphorylation supports amino acid-dependent Q2 mTORC1-directed signalling [PDF]
, 2015 The mammalian or mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a ubiquitously expressed multimeric protein kinase complex that integrates nutrient and growth factor signals for the co-ordinated regulation of cellular metabolism and cell ...
Alan Prescott +60 more
core +3 more sources
A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis
Molecular & Cellular Oncology, 2021 Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex 1 ...
Yuelong Yan, Guang Lei, Boyi Gan
doaj +1 more source
Autophagy regulates rRNA synthesis
Nucleus, 2022 Autophagy has emerged as a key regulator of cell metabolism. Recently, we have demonstrated that autophagy is involved in RNA metabolism by regulating ribosomal RNA (rRNA) synthesis.
Yinfeng Xu, Wei Wan
doaj +1 more source