Results 111 to 120 of about 41,665 (257)
GLP‐1 Receptor Agonists and Weight Loss: A Critical Review of Mechanisms
Obesity Reviews, EarlyView.ABSTRACT GLP‐1 receptor agonist medications have the potential to promote marked weight loss, but maximal and sustained benefit may be compromised by poor compliance and cessation of use. Development of next‐generation medications that address current obstacles to effective use and development of effective adjunct treatments will benefit from better ...
Giorgia Rutigliani +8 more
wiley +1 more source
Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction
Obesity Reviews, EarlyView.Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey +7 more
wiley +1 more source
Pacing and Clinical Electrophysiology, EarlyView.ABSTRACT Immune checkpoint inhibitors (ICIs) are now standard of care for most advanced solid tumors. While effective, they are associated with immune‐related adverse events (irAEs), including rare autonomic complications. We present a patient with metastatic lung adenocarcinoma receiving nivolumab and ipilimumab who developed reflex syncope with ...
Ashley Bouzon +3 more
wiley +1 more source
Experimental Physiology, EarlyView.Abstract Arterial shear‐mediated vasodilation is a well‐established measure of endothelial function and serves as a critical biomarker for cardiovascular disease risk. Endothelial function can be measured using a variety of experimental methodologies; however, the most widely adopted technique is ultrasound‐based flow‐mediated dilation (FMD), in which ...
Yi Zhen Bao +4 more
wiley +1 more source
Blue plaque review series: Thomas Graham Brown: Before his time
Experimental Physiology, EarlyView.Abstract Thomas Graham Brown made a seminal discovery, published in 1911 while he was a Carnegie Fellow in the University of Liverpool laboratory of Nobel Prize winner Charles S. Sherrington. Working in cats, he showed that rhythmic ‘voluntary’ behaviour, such as stepping and, by inference, walking, does not result from a chain of reflex events, but ...
Ronald L. Calabrese, Eve Marder
wiley +1 more source
Experimental Physiology, EarlyView.Abstract Sympathetic nervous system activation is a hallmark of high‐altitude hypoxia, yet the afferent mechanisms remain incompletely defined. We examined the relative contributions of pulmonary arterial mechanoreceptors and carotid chemoreceptors – two excitatory pathways co‐activated by hypoxia – to sustained sympathoexcitation at altitude.
Michiel T. Ewalts +13 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend This randomized cross‐over trial (N = 12) addressed the hypothesis that selective reduction of pulmonary arterial pressure (i.e. manipulation of pulmonary arterial mechanoreceptor activation) during hypoxic exercise would reduce sympathetic outflow (muscle sympathetic nerve activity (MSNA)) in healthy humans.
Michiel T. Ewalts +9 more
wiley +1 more source
Echinoderm stereom gradient structures enable mechanoelectrical perception. [PDF]
NatureChen A +10 more
europepmc +1 more source
Editorial: Vibratory therapy: impacts on endocrine disorders. [PDF]
Front Endocrinol (Lausanne)Bernardo-Filho M +3 more
europepmc +1 more source