Results 221 to 230 of about 39,386 (288)

Mechanically heterogeneous hydrogel with cell-programmed network restructuring promotes tissue regeneration by mechano-epigenetic modulation. [PDF]

Nat Commun
Ling Q, Li H, Zhao J, Guo W, Yu H, Li Z, Hu Y, Wei S, Fu Y, Zhang Y, Zhang K, Bian L.   +11 more
europepmc   +1 more source

A noncanonical role for Jagged1 in endothelial mechanotransduction

The FEBS Journal, EarlyView.
This study reveals a noncanonical role for Jagged1 in endothelial mechanotransduction. Shear stress modulates Jagged1 expression and subcellular localization. Loss of Jagged1 attenuates mechanotransduction and reduces Src, VEGFR2, and ERK signaling. Direct mechanical stimulation of Jagged1 induces activation of these signaling pathways.
Freddy Suarez Rodriguez, Noora Virtanen, Elmeri Kiviluoto, Rob C. H. Driessen, Feihu Zhao, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren   +7 more
wiley   +1 more source

Compressive stress-driven Piezo1 activation and Rho-ROCK mechanotransduction promote tumor progression via epigenetic mechanical memory. [PDF]

Sci Adv
Boyle ST, Gallego-Ortega D, Buckley EJ, Cognard E, Johan MZ, Esmaeili Z, Kamei M, Poole K, Samuel MS.   +8 more
europepmc   +1 more source

Beyond the chaos: How architecture structures tumour biology

The FEBS Journal, EarlyView.
Tissue architecture shapes tumour initiation and progression through multiple interconnected layers continuously remodelled over time. This review outlines how physical forces, biochemical cues, cellular niches and systemic influences contribute to tumour evolution.
Lea Dörner, Catrin Lutz, Stefan Prekovic, Hendrik A. Messal   +3 more
wiley   +1 more source

Connections between physics and metabolism in brain functions. [PDF]

iScience
Mochel F, de Oyarzábal Sanz A, Pías Peleteiro L, Ribeiro-Constante J, Bassereau P, Chalut K, Cognet L, Cronin L, Hameroff S, López-Murcia FJ, Pillai EK, Sales-Pardo M, Straube A, Hallou A, Garcia-Cazorla A.   +14 more
europepmc   +1 more source

Hydroxyapatite-Mediated Mechanical Modulation of GelMA Hydrogels Influences Osteogenic Differentiation of 3D Spheroids. [PDF]

Gels
Amarbayasgalan N, Kim JH, Koh WG, Muthuramalingam K, Lee HJ.   +4 more
europepmc   +1 more source

Resilient Biophysical Phenotype of Memory CD4+ T Cells in Long‐Lived Mice

Immunology, EarlyView.
Aging is associated with increased stiffness and reduced migratory capacity of memory CD4+ T cells; however, these biophysical declines do not persist in exceptionally long‐lived mice. Instead, long‐lived individuals preserve T cell mechanics, migration and intracellular architecture, supporting mechanical resilience as a hallmark of successful immune ...
Aldo Abarca‐Ortega, Blanca González‐Bermúdez, Judith Félix‐Escalera, Mónica González‐Sánchez, Enzo Brito, Mónica De la Fuente, Gustavo R. Plaza   +6 more
wiley   +1 more source

The Notch1 intracellular domain orchestrates mechanotransduction of fluid shear stress. [PDF]

Life Sci Alliance
Singh T, Jacobs KA, Polacheck WJ, Kutys ML.   +3 more
europepmc   +1 more source

Mechanobiology of the Nucleolus. [PDF]

Biol Cell
Shetty Y, Dolega ME.
europepmc   +1 more source

Effect of human myoblasts on tenogenic progression in 2D and 3D culture models

Journal of Anatomy, EarlyView.
We investigated whether factors released from muscle derived myogenic cells enhance tenogenic progressions of human tendon derived cells using two‐dimensional (2D) culture model and a three‐dimensional (3D)‐engineered tendon construct culture model.
Yoshifumi Tsuchiya, Ching‐Yan Chloé Yeung, Rene B. Svensson, Michael Kjaer   +3 more
wiley   +1 more source