Results 1 to 10 of about 3,772 (161)
Utility of T-cell immunosequencing in distinguishing mycosis fungoides progression from treatment related cutaneous adverse events [PDF]
Frontiers in Medicine, 2023 Cutaneous adverse events of both topical and systemic drugs in patients with mycosis fungoides (MF) present a diagnostic challenge as it is often difficult to distinguish drug associated rash from disease progression in the skin.
Safiyyah Bhatti +8 more
doaj +2 more sources
A practical and safer model of nitrogen mustard injury in cornea. [PDF]
PLoS ONEPurposeSulfur mustard (SM) is an alkylating agent used in warfare and terrorism that inflicts devastating ocular injuries. Although the clinical symptoms are well described, the underlying mechanisms are not fully understood, hindering the development of
Ana M Sandoval-Castellanos +6 more
doaj +2 more sources
Skin-Directed Therapies in Mycosis Fungoides: An Update [PDF]
Dermatology and TherapyMycosis fungoides (MF) is the most common subtype of cutaneous T cell lymphoma (CTCL), characterized by monoclonal proliferation of malignant T cells primarily involving the skin.
Maciej Tota +7 more
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In Vivo Evidence of Melatonin’s Protective Role in Alkylating-Agent-Induced Pulmonary Toxicity: A Systematic Review [PDF]
AntioxidantsAlkylating agents, historically employed as chemical warfare agents and currently used as chemotherapeutic drugs, are known to induce significant pulmonary toxicity. Current clinical interventions often fail to fully prevent or reverse these pathological
Emma Sola +4 more
doaj +2 more sources
DFT studies of metal oxide nanocluster as a possible drug delivery system for mechlorethamine [PDF]
BMC ChemistryThis study examined the adsorption of the mechlorethamine (ME) anti-cancer drug loaded upon Mg12O12 nanocage using DFT: B3LYP (6-31G* and 6-311G** basis set) and B3PW91 (6-31G* basis set) calculations.
Shahnaz Azari gharelar +3 more
doaj +2 more sources
Frontiers in Medicine, 2021 Topical chlormethine yields high response rates in mycosis fungoides cutaneous T-cell lymphoma with early discontinuation often attributed to skin reactions.
Christiane Querfeld +5 more
doaj +1 more source
HPLC-UV, MALDI-TOF-MS and ESI-MS/MS analysis of the mechlorethamine DNA crosslink at a cytosine-cytosine mismatch pair. [PDF]
PLoS ONE, 2011 Mechlorethamine [ClCH(2)CH(2)N(CH(3))CH(2)CH(2)Cl], a nitrogen mustard alkylating agent, has been proven to form a DNA interstrand crosslink at a cytosine-cytosine (C-C) mismatch pair using gel electrophoresis.
Pornchai Rojsitthisak +3 more
doaj +1 more source
Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapyinduced leukemia [PDF]
, 2001 Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophiles, including metabolites of several chemotherapeutic agents, some of which are suspected human carcinogens.
Allan, J.M. +9 more
core +7 more sources
Frontiers in Immunology, 2023 Mycoses fungoides (MF) and Sézary syndrome (SS) are cutaneous T-cell lymphomas that are often challenging to manage given the absence of reliably curative therapies, at times high symptom burden with significant detriment to quality of life, and need for
Robert Stuver, Shamir Geller
doaj +1 more source