Dysregulation of the mTOR pathway by mechlorethamine. [PDF]
Toxicology, 2023 Mechlorethamine (HN2) is a derivative of the chemical warfare agent sulfur mustard (SM) and cutaneous exposure to HN2 is associated with dermal-epidermal junction (DEJ) disruption (vesication). The primary purpose of the present study was to investigate the effect of HN2 on the mammalian target of rapamycin (mTOR) signaling pathway using an in vivo ...
Rao TJR, Mao G, Cuffari BJ, Billack B.
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Utility of T-cell immunosequencing in distinguishing mycosis fungoides progression from treatment related cutaneous adverse events [PDF]
Frontiers in Medicine, 2023 Cutaneous adverse events of both topical and systemic drugs in patients with mycosis fungoides (MF) present a diagnostic challenge as it is often difficult to distinguish drug associated rash from disease progression in the skin.
Safiyyah Bhatti +8 more
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Mechlorethamine gel usage in patients with mycosis fungoides in a lymphoma clinic
Indian Journal of Dermatology, 2020 Robert Duffy, Tara Jennings, Joya Sahu
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HPLC-UV, MALDI-TOF-MS and ESI-MS/MS analysis of the mechlorethamine DNA crosslink at a cytosine-cytosine mismatch pair. [PDF]
PLoS ONE, 2011 Mechlorethamine [ClCH(2)CH(2)N(CH(3))CH(2)CH(2)Cl], a nitrogen mustard alkylating agent, has been proven to form a DNA interstrand crosslink at a cytosine-cytosine (C-C) mismatch pair using gel electrophoresis.
Pornchai Rojsitthisak +3 more
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Depilatory double‐disc mouse model for evaluation of vesicant dermal injury pharmacotherapy countermeasures [PDF]
Animal Models and Experimental Medicine, 2023 Background Sulfur mustard (SM) is a chemical warfare vesicant that severely injures exposed eyes, lungs, and skin. Mechlorethamine hydrochloride (NM) is widely used as an SM surrogate.
Tomas L. Roldan +4 more
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Advances in the treatment of mycoses fungoides and Sézary syndrome: a narrative update in skin-directed therapies and immune-based treatments [PDF]
Frontiers in Immunology, 2023 Mycoses fungoides (MF) and Sézary syndrome (SS) are cutaneous T-cell lymphomas that are often challenging to manage given the absence of reliably curative therapies, at times high symptom burden with significant detriment to quality of life, and need for
Robert Stuver, Shamir Geller
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Mediterranean Journal of Hematology and Infectious Diseases, 2012 Patients with Hodgkin lymphoma treated with DNA-breaking alkylating agents such as mechlorethamine and procarbazine in the MOPP regimen and with topoisomerase II inhibitors, such as etoposide did show a long-term risk of developing therapy-related ...
Ercole Brusamolino +2 more
doaj +5 more sources
Accidental intramuscular injection of mechlorethamine [PDF]
Cancer, 1980 A 55-year-old man with chronic, active diffuse psoriasis was accidentally given 30 mg of mechlorethmine deep into the buttock muscles. About 5 hours after the intramuscular (IM) mechlorethamine injection, 1/6 M sodium thiosulfate was infused around the intramuscular site.
Oliver E. Owen +3 more
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Air embolism of the brain in rabbits pretreated with mechlorethamine. [PDF]
Stroke, 1991 Infusion of 400 microliters air into the left internal carotid artery of five anesthetized rabbits caused transient pial arteriole air embolism, an immediate 41.9 +/- 0.8% dilatation of the embolized vessels, suppression of the cortical somatosensory evoked response to 29.4 +/- 2.7% of baseline, and a progressive decline in ipsilateral cerebral blood ...
S. Helps, Des Gorman
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Experimental bronchial arterial infusion of mechlorethamine
The Journal of Thoracic and Cardiovascular Surgery, 1965 James B.D. Mark +2 more
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