A Little Experience Goes a Long Way: Chlormethine/Mechlorethamine Treatment Duration as a Function of Clinician-Level Patient Volume for Mycosis Fungoides Cutaneous T-Cell Lymphoma (MF-CTCL)—A Retrospective Cohort Study [PDF]
Frontiers in Medicine, 2021 Topical chlormethine yields high response rates in mycosis fungoides cutaneous T-cell lymphoma with early discontinuation often attributed to skin reactions.
Christiane Querfeld +5 more
doaj +3 more sources
DFT studies of metal oxide nanocluster as a possible drug delivery system for mechlorethamine [PDF]
BMC ChemistryThis study examined the adsorption of the mechlorethamine (ME) anti-cancer drug loaded upon Mg12O12 nanocage using DFT: B3LYP (6-31G* and 6-311G** basis set) and B3PW91 (6-31G* basis set) calculations.
Shahnaz Azari gharelar +3 more
doaj +3 more sources
Dysregulation of the mTOR pathway by mechlorethamine [PDF]
Toxicology, 2023 Mechlorethamine (HN2) is a derivative of the chemical warfare agent sulfur mustard (SM) and cutaneous exposure to HN2 is associated with dermal-epidermal junction (DEJ) disruption (vesication). The primary purpose of the present study was to investigate the effect of HN2 on the mammalian target of rapamycin (mTOR) signaling pathway using an in vivo ...
Trishaal Janardhanam Raghavendra, Rao +3 more
semanticscholar +4 more sources
Utility of T-cell immunosequencing in distinguishing mycosis fungoides progression from treatment related cutaneous adverse events [PDF]
Frontiers in Medicine, 2023 Cutaneous adverse events of both topical and systemic drugs in patients with mycosis fungoides (MF) present a diagnostic challenge as it is often difficult to distinguish drug associated rash from disease progression in the skin.
Safiyyah Bhatti +8 more
doaj +2 more sources
HPLC-UV, MALDI-TOF-MS and ESI-MS/MS analysis of the mechlorethamine DNA crosslink at a cytosine-cytosine mismatch pair. [PDF]
PLoS ONE, 2011 Mechlorethamine [ClCH(2)CH(2)N(CH(3))CH(2)CH(2)Cl], a nitrogen mustard alkylating agent, has been proven to form a DNA interstrand crosslink at a cytosine-cytosine (C-C) mismatch pair using gel electrophoresis.
Pornchai Rojsitthisak +3 more
doaj +3 more sources
A practical and safer model of nitrogen mustard injury in cornea. [PDF]
PLoS ONEPurposeSulfur mustard (SM) is an alkylating agent used in warfare and terrorism that inflicts devastating ocular injuries. Although the clinical symptoms are well described, the underlying mechanisms are not fully understood, hindering the development of
Ana M Sandoval-Castellanos +6 more
doaj +2 more sources
Skin-Directed Therapies in Mycosis Fungoides: An Update [PDF]
Dermatology and TherapyMycosis fungoides (MF) is the most common subtype of cutaneous T cell lymphoma (CTCL), characterized by monoclonal proliferation of malignant T cells primarily involving the skin.
Maciej Tota +7 more
doaj +2 more sources
In Vivo Evidence of Melatonin’s Protective Role in Alkylating-Agent-Induced Pulmonary Toxicity: A Systematic Review [PDF]
AntioxidantsAlkylating agents, historically employed as chemical warfare agents and currently used as chemotherapeutic drugs, are known to induce significant pulmonary toxicity. Current clinical interventions often fail to fully prevent or reverse these pathological
Emma Sola +4 more
doaj +2 more sources
Mediterranean Journal of Hematology and Infectious Diseases, 2012 Patients with Hodgkin lymphoma treated with DNA-breaking alkylating agents such as mechlorethamine and procarbazine in the MOPP regimen and with topoisomerase II inhibitors, such as etoposide did show a long-term risk of developing therapy-related ...
Ercole Brusamolino +2 more
doaj +5 more sources
Depilatory double‐disc mouse model for evaluation of vesicant dermal injury pharmacotherapy countermeasures [PDF]
Animal Models and Experimental Medicine, 2023 Background Sulfur mustard (SM) is a chemical warfare vesicant that severely injures exposed eyes, lungs, and skin. Mechlorethamine hydrochloride (NM) is widely used as an SM surrogate.
Tomas L. Roldan +4 more
doaj +2 more sources