Dysregulation of the mTOR pathway by mechlorethamine
Toxicology, 2023 Mechlorethamine (HN2) is a derivative of the chemical warfare agent sulfur mustard (SM) and cutaneous exposure to HN2 is associated with dermal-epidermal junction (DEJ) disruption (vesication). The primary purpose of the present study was to investigate the effect of HN2 on the mammalian target of rapamycin (mTOR) signaling pathway using an in vivo ...
Trishaal Janardhanam Raghavendra, Rao +3 more
semanticscholar +5 more sources
Evaluation and management of patients with early-stage mycosis fungoides who interrupt or discontinue topical mechlorethamine gel because of dermatitis [PDF]
JAAD Case Reports, 2020 Elaine S. Gilmore, MD, PhD +3 more
doaj +3 more sources
Frontiers in Medicine, 2021 Topical chlormethine yields high response rates in mycosis fungoides cutaneous T-cell lymphoma with early discontinuation often attributed to skin reactions.
Christiane Querfeld +5 more
doaj +2 more sources
Depilatory double‐disc mouse model for evaluation of vesicant dermal injury pharmacotherapy countermeasures [PDF]
Animal Models and Experimental Medicine, 2023 Background Sulfur mustard (SM) is a chemical warfare vesicant that severely injures exposed eyes, lungs, and skin. Mechlorethamine hydrochloride (NM) is widely used as an SM surrogate.
Tomas L. Roldan +4 more
doaj +2 more sources
Optimizing treatment efficacy and fertility preservation in patients undergoing hematopoietic stem cell transplantation: A narrative review of ovarian shielding with total-body irradiation or treosulfan-based conditioning regimens. [PDF]
Reprod Med BiolAbstract Background Pediatric and adolescent/young adult (AYA) patients with hematologic malignancies often require hematopoietic stem cell transplantation (HSCT) using conditioning regimens that pose high risks for gonadal toxicity. Traditional protocols, including total body irradiation (TBI) and busulfan‐based regimens, can impair fertility.
Tanaka Y +7 more
europepmc +2 more sources
Accidental intramuscular injection of mechlorethamine [PDF]
Cancer, 1980 A 55-year-old man with chronic, active diffuse psoriasis was accidentally given 30 mg of mechlorethmine deep into the buttock muscles. About 5 hours after the intramuscular (IM) mechlorethamine injection, 1/6 M sodium thiosulfate was infused around the intramuscular site.
Eugene J. Van Scott +3 more
openaire +4 more sources
Necrobiotic Xanthogranuloma Treated With Topical Nitrogen Mustard (Mechlorethamine) [PDF]
JAMA Dermatology, 2016 Necrobiotic Xanthogranuloma Treated With Topical Nitrogen Mustard (Mechlorethamine) Necrobiotic xanthogranuloma (NXG) is a chronic, progressive skin condition characterized by a granulomatous reaction with the potential to affect multiple organs that ...
Charles Meyers +4 more
semanticscholar +5 more sources
Post hoc Analysis of a Randomized, Controlled, Phase 2 Study to Assess Response Rates with Chlormethine/Mechlorethamine Gel in Patients with Stage IA–IIA Mycosis Fungoides [PDF]
Dermatology, 2021 Background: Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma. Patients can be treated using chlormethine gel, a skin-directed therapy developed and approved for MF.
Christiane Querfeld +8 more
openalex +2 more sources
Air embolism of the brain in rabbits pretreated with mechlorethamine. [PDF]
Stroke, 1991 Infusion of 400 microliters air into the left internal carotid artery of five anesthetized rabbits caused transient pial arteriole air embolism, an immediate 41.9 +/- 0.8% dilatation of the embolized vessels, suppression of the cortical somatosensory evoked response to 29.4 +/- 2.7% of baseline, and a progressive decline in ipsilateral cerebral blood ...
Stephen C. Helps, D F Gorman
openaire +4 more sources