Examination of a Chimeric Bis-Electrophile for Selective DNA-Protein Cross-Linking and Mechlorethamine Reveals an Unknown Source of Nitrogen Mustard Cytotoxicity. [PDF]
J Am Chem SocDNA-protein cross-links (DPCs) are cytotoxic lesions whose study in cells is complicated by the lack of exogenous agents that produce them selectively over DNA-DNA interstrand cross-links (ICLs).
Jiang X, Vu S, Yu H, Greenberg MM.
europepmc +7 more sources
Topical Mechlorethamine for the Treatment of Psoriasis: A Report of Two Cases and Literature Review. [PDF]
Dermatol Ther (Heidelb), 2023 Introduction Psoriasis is a common inflammatory skin disease that significantly impacts patients’ psychosocial wellbeing. Despite increasingly effective treatment options, the recurrence of plaques after discontinuation of therapy in many patients ...
Fahmy LM +4 more
europepmc +4 more sources
Mechlorethamine Oxide Hydrochloride [PDF]
Definitions, 2020 National Cancer Institute
semanticscholar +3 more sources
Mechlorethamine Hydrochloride Gel [PDF]
Definitions, 2020 A gel formulation composed of the hydrochloride salt form of mechlorethamine, which is a nitrogen mustard alkylating agent and an analog of sulfur mustard, with antineoplastic and immunosuppressive activities. Upon topical application, mechlorethamine is
National Cancer Institute
semanticscholar +3 more sources
Mechlorethamine gel usage in patients with mycosis fungoides in a lymphoma clinic
Indian Journal of Dermatology, 2020 1. Galimont-Collen AF, Vos LE, Lavrijsen AP, Ouwerkerk J, Gelderblom H. Classification and management of skin, hair, nail and mucosal side-effects of epidermal growth factor receptor (EGFR) inhibitors. Eur J Cancer 2007;43:845-51. 2.
Robert Duffy, Tara Jennings, Joya Sahu
doaj +3 more sources
Necrobiotic Xanthogranuloma Treated With Topical Nitrogen Mustard (Mechlorethamine) [PDF]
JAMA Dermatology, 2016 Olaf, Rodriguez +4 more
semanticscholar +4 more sources
Accidental intramuscular injection of mechlorethamine [PDF]
Cancer, 1980 A 55-year-old man with chronic, active diffuse psoriasis was accidentally given 30 mg of mechlorethmine deep into the buttock muscles. About 5 hours after the intramuscular (IM) mechlorethamine injection, 1/6 M sodium thiosulfate was infused around the intramuscular site.
O E, Owen +3 more
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Post hoc Analysis of a Randomized, Controlled, Phase 2 Study to Assess Response Rates with Chlormethine/Mechlorethamine Gel in Patients with Stage IA–IIA Mycosis Fungoides [PDF]
Dermatology, 2021 Background: Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma. Patients can be treated using chlormethine gel, a skin-directed therapy developed and approved for MF.
Christiane Querfeld +8 more
openalex +2 more sources