Results 21 to 30 of about 3,791 (174)

Depilatory double‐disc mouse model for evaluation of vesicant dermal injury pharmacotherapy countermeasures

Animal Models and Experimental Medicine, 2023
Background Sulfur mustard (SM) is a chemical warfare vesicant that severely injures exposed eyes, lungs, and skin. Mechlorethamine hydrochloride (NM) is widely used as an SM surrogate.
Tomas L. Roldan, Shike Li, Jeffrey D. Laskin, Dayuan Gao, Patrick J. Sinko   +4 more
doaj   +1 more source

Linfoma Não Hodgkin de Células T Citotóxico: uma Apresentação Clínica Atípica [PDF]

, 2013
Cytotoxic lymphomas comprise a spectrum of peripheral T-cell lymphomas that can have a initial or late cutaneous presentation. We describe a 46-year-old man from Cape Verde, with a dermatosis involving his face and trunk, consisting of monomorphic ...
Afonso, A, Bento, D, Kutzner, H, Maio, P, Sachse, F, Vieira, R   +5 more
core   +3 more sources

Synthesis of structurally diverse major groove DNA interstrand crosslinks using three different aldehyde precursors [PDF]

, 2014
DNA interstrand crosslinks (ICLs) are extremely cytotoxic lesions that block essential cellular processes, such as replication and transcription. Crosslinking agents are widely used in cancer chemotherapy and form an array of structurally diverse ICLs ...
A. Guainazzi, Angelov, Clauson, Dong, Dooley, Dutta, Guainazzi, Guan, Humphrey, Kozekov, Langevin, Lawley, McHugh, Moldovan, Noll, Noll, O. D. Scharer, Rajski, S. Mukherjee, Sawyer, Sch  rer, Smeaton, Smeaton, Stone, Wilds, Wilds, Yamanaka   +26 more
core   +1 more source

Fecal microbiota diversity in survivors of adolescent/young adult Hodgkin lymphoma: A study of twins [PDF]

, 2013
BACKGROUND: Adolescent/young adult Hodgkin lymphoma (AYAHL) survivors report fewer exposures to infections during childhood compared with controls, and they have functional lymphocyte aberrations.
Cozen, Wendy, Gail, Mitchell H, Goedert, James J, Gordon, Jeffrey I, Hamilton, Ann S, Hwang, Amie E, Mack, Thomas M, Nathwani, Bharat N, Ridaura, Vanessa K, Yu, Guoqin   +9 more
core   +2 more sources

A Rare Case of Hodgkin Lymphoma With Isolated Epitrochlear Lymphadenopathy. Our Experience and Main Differential Diagnosis. [PDF]

Case Rep Med
Hodgkin lymphoma (HL) is a type of lymphoma, characterized by the presence of abnormal Reed‐Sternberg cells. It typically affects lymph nodes, generally in the upper body (such as neck, chest, and armpits). It can also involve the spleen, liver, and bone marrow. In the literature, there are sporadic cases of atypical localization of HL. The aim of this
Cea L, Santucci D, Bernetti C, Nibid L, Tomarchio V, Bruno A, Beomonte Zobel B, Grasso RF, Faiella E.   +8 more
europepmc   +2 more sources

Flow cytometric characterization and clinical outcome of CD4+ T-cell lymphoma in dogs: 67 cases. [PDF]

, 2014
BackgroundCanine T-cell lymphoma (TCL) is conventionally considered an aggressive disease, but some forms are histologically and clinically indolent. CD4 TCL is reported to be the most common subtype of TCL.
Avery, AC, Avery, PR, Bromberek, JL, Burton, J, Correa, S, Ehrhart, EJ, Elmslie, R, Morley, PS, Seelig, DM   +8 more
core   +2 more sources

Risk-Stratified and Response-Adapted Therapy for Pediatric Hodgkin Lymphoma in Argentina: The GATLA Experience. [PDF]

Adv Hematol
Background: The international cooperation between GATLA and AHOPCA with the support of St. Jude led to the adoption of the OEPA/COPDAC as a strategy to improve outcomes in high risk (HR) patients with HL. This study also includes the ABVD regimen for intermediate risk (IR) and low risk (LR) patients. Methods: Patients were stratified by predefined risk
Veron D, Streitenberger P, Matus M, Negri Aranguren P, Costa A, Morell D, Terrasa S, Castellanos EM, de Alarcon P, Dibar E, Makiya M.   +10 more
europepmc   +2 more sources

Optimizing treatment efficacy and fertility preservation in patients undergoing hematopoietic stem cell transplantation: A narrative review of ovarian shielding with total-body irradiation or treosulfan-based conditioning regimens. [PDF]

Reprod Med Biol
Abstract Background Pediatric and adolescent/young adult (AYA) patients with hematologic malignancies often require hematopoietic stem cell transplantation (HSCT) using conditioning regimens that pose high risks for gonadal toxicity. Traditional protocols, including total body irradiation (TBI) and busulfan‐based regimens, can impair fertility.
Tanaka Y, Hanada T, Amano T, Takahashi A, Deguchi M, Yamanaka H, Tsuji S, Murakami T.   +7 more
europepmc   +2 more sources

Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs [PDF]

, 2017
Quinone-based compounds have been exploited to treat infectious diseases and cancer, with such chemicals often functioning as inhibitors of key metabolic pathways or as prodrugs.
Alsford, Sam, Horn, David, Konno, Aya, Kumar, Ambika, Meredith, Emma Louise, Seifert, Karin, Szular, Joanna, Wilkinson, Shane R.   +7 more
core   +4 more sources

The Management of Classical Hodgkin's Lymphoma: Past, Present, and Future

Advances in Hematology, 2011
The management of classical Hodgkin's lymphoma (CHL) is a success story of modern multi-agent haemato-oncology. Prior to the middle of the twentieth century CHL was fatal in the majority of cases.
S. E. Richardson, C. McNamara
doaj   +1 more source