Topical Mechlorethamine for the Treatment of Psoriasis: A Report of Two Cases and Literature Review. [PDF]
Dermatol Ther (Heidelb), 2023 Introduction Psoriasis is a common inflammatory skin disease that significantly impacts patients’ psychosocial wellbeing. Despite increasingly effective treatment options, the recurrence of plaques after discontinuation of therapy in many patients ...
Fahmy LM +4 more
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Cancer Biology & Treatmen, 2021 Mechlorethamine (ME) is an antineoplastic agent which has been in clinical use for more than six decades. ME therapy is associated with high toxicity, and it is often in combination with other therapeutics.
Georgi L. Lukov, Theresa Tuthill
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Sulfur Mustard Analog Mechlorethamine (Bis(2-chloroethyl)methylamine) Modulates Cell Cycle Progression via the DNA Damage Response in Human Lung Epithelial A549 Cells [PDF]
Chemical Research in Toxicology, 2019 Nitrogen mustard, mechlorethamine (bis(2-chloroethyl)methylamine; HN2), and sulfur mustard are potent vesicants that modify and disrupt cellular macromolecules including DNA leading to cytotoxicity and tissue injury.
Yi‐Hua Jan +3 more
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Randomized Mechlorethamine/Chlormethine Induced Dermatitis Assessment Study (MIDAS) Establishes Benefit of Topical Triamcinolone 0.1% Ointment Cotreatment in Mycosis Fungoides. [PDF]
Dermatol Ther (Heidelb), 2022 Treatment of early-stage mycosis fungoides (MF) requires safe, skin-directed therapies. Medication side effects can lead to underutilization of effective therapies.
Alexander-Savino CV +4 more
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Mechlorethamine Hydrochloride Gel [PDF]
Definitions, 2020 A gel formulation composed of the hydrochloride salt form of mechlorethamine, which is a nitrogen mustard alkylating agent and an analog of sulfur mustard, with antineoplastic and immunosuppressive activities. Upon topical application, mechlorethamine is
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Real-world experience with mechlorethamine gel in patients with mycosis fungoides-cutaneous lymphoma: Preliminary findings from a prospective observational study [PDF]
Journal of American Academy of Dermatology, 2020 Ellen J. Kim +9 more
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Acta Dermato-Venereologica, 2021 Mycosis fungoides is a type of cutaneous T-cell lymphoma, which accounts for the majority of cases of cutaneous T-cell lymphoma. Mycosis fungoides can be classified as early-stage (IA–IIA) or late-stage (IIB or greater) disease.
Tiffany J. Garcia-Saleem +3 more
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Gloves Standards and Occupational Exposure to Antineoplastic Drugs in the European Context. [PDF]
Health Sci RepABSTRACT Background and Aims Over 12 million healthcare professionals in Europe are exposed to hazardous medicinal products, including antineoplastic drugs. Dermal route is recognized as the primary route of exposure to antineoplastic drugs, emphasizing the critical importance of skin protection provided by gloves, which necessitates a careful and ...
Swierczynski G +2 more
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Optimizing treatment efficacy and fertility preservation in patients undergoing hematopoietic stem cell transplantation: A narrative review of ovarian shielding with total-body irradiation or treosulfan-based conditioning regimens. [PDF]
Reprod Med BiolAbstract Background Pediatric and adolescent/young adult (AYA) patients with hematologic malignancies often require hematopoietic stem cell transplantation (HSCT) using conditioning regimens that pose high risks for gonadal toxicity. Traditional protocols, including total body irradiation (TBI) and busulfan‐based regimens, can impair fertility.
Tanaka Y +7 more
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Ebselen oxide attenuates mechlorethamine dermatotoxicity in the mouse ear vesicant model [PDF]
Drug and chemical toxicology (New York, N.Y. 1978), 2018 Mechlorethamine (HN2) is an alkylating agent and sulfur mustard mimetic. Topical exposure to HN2 is associated with tissue blistering. Previous work in our laboratory has shown that ebselen (EB-1) possesses anti-vesicant, anti-inflammatory, anti ...
Hemanta C Rao Tumu +5 more
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