Results 41 to 50 of about 5,025 (229)
Frontiers in Immunology, 2023 Mycoses fungoides (MF) and Sézary syndrome (SS) are cutaneous T-cell lymphomas that are often challenging to manage given the absence of reliably curative therapies, at times high symptom burden with significant detriment to quality of life, and need for
Robert Stuver, Shamir Geller
doaj +1 more source
Chlormethine Gel is Efficient and Safe in Mycosis Fungoides Skin Lesions
Acta Dermato-Venereologica, 2022 Chlormethine is a bifunctional cytotoxic alkylating agent that binds to DNA, resulting in cell death (apoptosis). Chlormethine (also known as mechlorethamine) gel (CL gel) was approved in the European Union in 2017 and was first used in 2019.
Marios Koumourtzis +3 more
doaj +1 more source
Minor structural modifications to alchemix influence mechanism of action and pharmacological activity [PDF]
, 2012 Alchemix is an exemplar of a class of anthraquinone with efficacy against multidrug resistant tumors. We have explored further the mechanism of action of alchemix and investigated the effect of extending its side arm bearing the alkylating functionality ...
Abdallah, QMA +12 more
core +1 more source
Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapyinduced leukemia [PDF]
, 2001 Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophiles, including metabolites of several chemotherapeutic agents, some of which are suspected human carcinogens.
Allan, J.M. +9 more
core +7 more sources
NAD+ Acts as a Protective Factor in Cellular Stress Response to DNA Alkylating Agents
Cells, 2023 Sulfur mustard (SM) and its derivatives are potent genotoxic agents, which have been shown to trigger the activation of poly (ADP-ribose) polymerases (PARPs) and the depletion of their substrate, nicotinamide adenine dinucleotide (NAD+).
Joanna Ruszkiewicz +10 more
doaj +1 more source
Cells, 2023 Caenorhabditis elegans (C. elegans) is gaining recognition and importance as an organismic model for toxicity testing in line with the 3Rs principle (replace, reduce, refine). In this study, we explored the use of C.
Joanna Ruszkiewicz +4 more
doaj +1 more source
Periodic shock-emission from acoustically driven cavitation clouds:a source of the subharmonic signal [PDF]
, 2014 Single clouds of cavitation bubbles, driven by 254 kHz focused ultrasound at pressure amplitudes in the range of 0.48–1.22 MPa, have been observed via high-speed shadowgraphic imaging at 1 × 10⁶ frames per second.
Cochran, Sandy +6 more
core +5 more sources
Synthesis of structurally diverse major groove DNA interstrand crosslinks using three different aldehyde precursors [PDF]
, 2014 DNA interstrand crosslinks (ICLs) are extremely cytotoxic lesions that block essential cellular processes, such as replication and transcription. Crosslinking agents are widely used in cancer chemotherapy and form an array of structurally diverse ICLs ...
A. Guainazzi +26 more
core +1 more source
Proposal for a new therapy for drug-resistant malaria using Plasmodium synthetic lethality inference [PDF]
, 2013 Many antimalarial drugs kill malaria parasites, but antimalarial drug resistance (ADR) and toxicity to normal cells limit their usefulness. To solve this problem, we suggest a new therapy for drug-resistant malaria.
Cho, Yonghyun +2 more
core +1 more source