Current Research in Toxicology, 2021 The purpose of the present study was to investigate the vesicant countermeasure effects of hydrocortisone (HC) and ebselen (EB-1), administered as monotherapy or as a combination treatment.
Hemanta C Rao Tumu +2 more
doaj +1 more source
Risk-Stratified and Response-Adapted Therapy for Pediatric Hodgkin Lymphoma in Argentina: The GATLA Experience. [PDF]
Adv HematolBackground: The international cooperation between GATLA and AHOPCA with the support of St. Jude led to the adoption of the OEPA/COPDAC as a strategy to improve outcomes in high risk (HR) patients with HL. This study also includes the ABVD regimen for intermediate risk (IR) and low risk (LR) patients. Methods: Patients were stratified by predefined risk
Veron D +10 more
europepmc +2 more sources
A Rare Case of Hodgkin Lymphoma With Isolated Epitrochlear Lymphadenopathy. Our Experience and Main Differential Diagnosis. [PDF]
Case Rep MedHodgkin lymphoma (HL) is a type of lymphoma, characterized by the presence of abnormal Reed‐Sternberg cells. It typically affects lymph nodes, generally in the upper body (such as neck, chest, and armpits). It can also involve the spleen, liver, and bone marrow. In the literature, there are sporadic cases of atypical localization of HL. The aim of this
Cea L +8 more
europepmc +2 more sources
Optimizing treatment efficacy and fertility preservation in patients undergoing hematopoietic stem cell transplantation: A narrative review of ovarian shielding with total-body irradiation or treosulfan-based conditioning regimens. [PDF]
Reprod Med BiolAbstract Background Pediatric and adolescent/young adult (AYA) patients with hematologic malignancies often require hematopoietic stem cell transplantation (HSCT) using conditioning regimens that pose high risks for gonadal toxicity. Traditional protocols, including total body irradiation (TBI) and busulfan‐based regimens, can impair fertility.
Tanaka Y +7 more
europepmc +2 more sources
Chlormethine Gel is Efficient and Safe in Mycosis Fungoides Skin Lesions
Acta Dermato-Venereologica, 2022 Chlormethine is a bifunctional cytotoxic alkylating agent that binds to DNA, resulting in cell death (apoptosis). Chlormethine (also known as mechlorethamine) gel (CL gel) was approved in the European Union in 2017 and was first used in 2019.
Marios Koumourtzis +3 more
doaj +1 more source
Absolute monocyte count and lymphocyte-monocyte ratio predict outcome in nodular sclerosis Hodgkin lymphoma: Evaluation based on data from 1450 patients [PDF]
, 2015 Objective: To verify whether absolute monocyte count (AMC) and lymphocyte-monocyte ratio (LMR) at diagnosis are valid prognostic parameters in classical Hodgkin lymphoma (cHL).
Aviv, Ariel +13 more
core +1 more source
NAD+ Acts as a Protective Factor in Cellular Stress Response to DNA Alkylating Agents
Cells, 2023 Sulfur mustard (SM) and its derivatives are potent genotoxic agents, which have been shown to trigger the activation of poly (ADP-ribose) polymerases (PARPs) and the depletion of their substrate, nicotinamide adenine dinucleotide (NAD+).
Joanna Ruszkiewicz +10 more
doaj +1 more source
His+ reversions Caused in Salmonella typhimurium by different types of ionizing radiation [PDF]
, 1988 The yield of his+ reversions in the Ames Salmonella tester strain TA2638 has been determined for 60Co γ rays, 140 kV X rays, 5.4 keV characteristic X rays, 2.2 MeV protons, 3.1 MeV α particles, and 18 MeV/U Fe ions.
Fitzek, M. +3 more
core +1 more source
Cells, 2023 Caenorhabditis elegans (C. elegans) is gaining recognition and importance as an organismic model for toxicity testing in line with the 3Rs principle (replace, reduce, refine). In this study, we explored the use of C.
Joanna Ruszkiewicz +4 more
doaj +1 more source
Cancer Biology & Treatmen, 2021 Mechlorethamine (ME) is an antineoplastic agent which has been in clinical use for more than six decades. ME therapy is associated with high toxicity, and it is often in combination with other therapeutics.
Georgi L. Lukov, Tuthill T
semanticscholar +1 more source