Linfoma Não Hodgkin de Células T Citotóxico: uma Apresentação Clínica Atípica [PDF]
, 2013 Cytotoxic lymphomas comprise a spectrum of peripheral T-cell lymphomas that can have a initial or late cutaneous presentation. We describe a 46-year-old man from Cape Verde, with a dermatosis involving his face and trunk, consisting of monomorphic ...
Afonso, A +5 more
core +3 more sources
Fecal microbiota diversity in survivors of adolescent/young adult Hodgkin lymphoma: A study of twins [PDF]
, 2013 BACKGROUND: Adolescent/young adult Hodgkin lymphoma (AYAHL) survivors report fewer exposures to infections during childhood compared with controls, and they have functional lymphocyte aberrations.
Cozen, Wendy +9 more
core +2 more sources
Synthesis of structurally diverse major groove DNA interstrand crosslinks using three different aldehyde precursors [PDF]
, 2014 DNA interstrand crosslinks (ICLs) are extremely cytotoxic lesions that block essential cellular processes, such as replication and transcription. Crosslinking agents are widely used in cancer chemotherapy and form an array of structurally diverse ICLs ...
A. Guainazzi +26 more
core +1 more source
Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs [PDF]
, 2017 Quinone-based compounds have been exploited to treat infectious diseases and cancer, with such chemicals often functioning as inhibitors of key metabolic pathways or as prodrugs.
Alsford, Sam +7 more
core +4 more sources
The Management of Classical Hodgkin's Lymphoma: Past, Present, and Future
Advances in Hematology, 2011 The management of classical Hodgkin's lymphoma (CHL) is a success story of modern multi-agent haemato-oncology. Prior to the middle of the twentieth century CHL was fatal in the majority of cases.
S. E. Richardson, C. McNamara
doaj +1 more source
Mediastinal Choriocarcinoma Masquerading as Relapsed Hodgkin Lymphoma
Case Reports in Oncology, 2011 Primary mediastinal choriocarcinoma is a rare extragonadal germ cell malignancy. We describe the first case of a patient who developed mediastinal choriocarcinoma after treatment for Hodgkin lymphoma (HL).
Selay Lam +2 more
doaj +1 more source
DNA repair modulates the vulnerability of the developing brain to alkylating agents [PDF]
, 2008 Neurons of the developing brain are especially vulnerable to environmental agents that damage DNA (i.e., genotoxicants), but the mechanism is poorly understood.
A. Olivas +70 more
core +1 more source
The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma [PDF]
, 2018 Background: The use of alkylating agents such as temozolomide in association with radiotherapy (RT) is the therapeutic standard of glioblastoma (GBM).
Chen, Yi +12 more
core +2 more sources
ChemistryCancer has a threatening impact on human health, and it is one of the primary causes of fatalities worldwide. Different conventional treatments have been employed to treat cancer, but their non-specific nature reduces their therapeutic efficacy.
Syeda Huda Mehdi Zaidi +3 more
doaj +1 more source
Flow cytometric characterization and clinical outcome of CD4+ T-cell lymphoma in dogs: 67 cases. [PDF]
, 2014 BackgroundCanine T-cell lymphoma (TCL) is conventionally considered an aggressive disease, but some forms are histologically and clinically indolent. CD4 TCL is reported to be the most common subtype of TCL.
Avery, AC +8 more
core +2 more sources