Results 11 to 20 of about 15,547 (147)

Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation

Disease Models & Mechanisms, 2017
Mutations in MECP2 cause Rett syndrome, a severe neurological disorder with autism-like features. Duplication of MECP2 also causes severe neuropathology.
M. van der Vaart, O. Svoboda, B. G. Weijts, R. Espín-Palazón, V. Sapp, T. Pietri, M. Bagnat, A. R. Muotri, D. Traver   +8 more
doaj   +1 more source

MeCP2-induced heterochromatin organization is driven by oligomerization-based liquid–liquid phase separation and restricted by DNA methylation

Nucleus, 2022
Heterochromatin is the highly compacted form of chromatin with various condensation levels hallmarked by high DNA methylation. MeCP2 is mostly known as a DNA methylation reader but has also been reported as a heterochromatin organizer.
Hui Zhang, Hector Romero, Annika Schmidt, Katalina Gagova, Weihua Qin, Bianca Bertulat, Anne Lehmkuhl, Manuela Milden, Malte Eck, Tobias Meckel, Heinrich Leonhardt, M. Cristina Cardoso   +11 more
doaj   +1 more source

Methyl-CpG binding protein 2 (Mecp2) Regulates Sensory Function through Sema5b and Robo2

Frontiers in Cellular Neuroscience, 2015
Mutations in the gene encoding the MECP2 underlies Rett syndrome, a neurodevelopmental disorder in young females. Although reduced pain sensitivity in Rett syndrome patients and in partial MeCP2 deficient mice had been reported, these previous studies ...
Wan Ying eLeong, Zhi Hao eLim, Vladimir eKorzh, Thomas ePIETRI, Eyleen L Goh   +4 more
doaj   +1 more source

Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity

Epigenetics, 2017
MeCP2 binds to methylated DNA in a chromatin context and has an important role in cancer and brain development and function. Histone deacetylase (HDAC) inhibitors are currently being used to palliate many cancer and neurological disorders.
Katrina V. Good, Alexia Martínez de Paz, Monica Tyagi, Manjinder S. Cheema, Anita A. Thambirajah, Taylor L. Gretzinger, Gilda Stefanelli, Robert L. Chow, Oliver Krupke, Michael Hendzel, Kristal Missiaen, Alan Underhill, Nicoletta Landsberger, Juan Ausió   +13 more
doaj   +1 more source

A role for MeCP2 in switching gene activity via chromatin unfolding and HP1γ displacement.

PLoS ONE, 2013
Methyl-CpG-binding protein 2 (MeCP2) is generally considered to act as a transcriptional repressor, whereas recent studies suggest that MeCP2 is also involved in transcription activation.
Maartje C Brink, Diewertje G E Piebes, Marloes L de Groote, Martijn S Luijsterburg, Corella S Casas-Delucchi, Roel van Driel, Marianne G Rots, M Cristina Cardoso, Pernette J Verschure   +8 more
doaj   +1 more source

MicroRNAs downregulated in neuropathic pain regulate MeCP2 and BDNF related to pain sensitivity

FEBS Open Bio, 2015
Nerve injury induces chronic pain and dysregulation of microRNAs in dorsal root ganglia (DRG). Several downregulated microRNAs are predicted to targetMecp2. MECP2 mutations cause Rett syndrome and these patients report decreased pain perception.
Melissa T. Manners, Yuzhen Tian, Zhaolan Zhou, Seena K. Ajit   +3 more
doaj   +1 more source

Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation

Neurobiology of Disease, 2009
Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the gene MECP2, encoding methyl-CpG-binding protein 2 (MeCP2). Few studies have explored dendritic morphology phenotypes in mouse models of RTT and none have determined
Nadia P. Belichenko, Pavel V. Belichenko, William C. Mobley   +2 more
doaj   +1 more source

Whole brain delivery of an instability-prone Mecp2 transgene improves behavioral and molecular pathological defects in mouse models of Rett syndrome

eLife, 2020
Rett syndrome is an incurable neurodevelopmental disorder caused by mutations in the gene encoding for methyl-CpG binding-protein 2 (MeCP2). Gene therapy for this disease presents inherent hurdles since MECP2 is expressed throughout the brain and its ...
Mirko Luoni, Serena Giannelli, Marzia Tina Indrigo, Antonio Niro, Luca Massimino, Angelo Iannielli, Laura Passeri, Fabio Russo, Giuseppe Morabito, Piera Calamita, Silvia Gregori, Benjamin Deverman, Vania Broccoli   +12 more
doaj   +1 more source

Impact of a 12-month multifaceted neurological physiotherapy intervention on gross motor function in women with Rett syndrome

Journal of Integrative Neuroscience, 2022
Background: Rett syndrome is a rare genetic neurological syndrome that affects mostly females. The syndrome leads to severe impairments impacting all areas of the affected persons' life, including speech, mobility, eating, and breathing impairments.
Alen Kapel, Tine Kovacic, Natasa Kos, Tomaz Velnar   +3 more
doaj   +1 more source

Brain region-specific expression of MeCP2 isoforms correlates with DNA methylation within Mecp2 regulatory elements.

PLoS ONE, 2014
MeCP2 is a critical epigenetic regulator in brain and its abnormal expression or compromised function leads to a spectrum of neurological disorders including Rett Syndrome and autism.
Carl O Olson, Robby M Zachariah, Chinelo D Ezeonwuka, Vichithra R B Liyanage, Mojgan Rastegar   +4 more
doaj   +1 more source