Results 61 to 70 of about 4,221 (131)

Examining the Reliability of Model‐Based Meta‐Analysis (MBMA) Outcomes: A Simulation Study

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Model‐based meta‐analysis (MBMA) can be utilized to synthesize literature data and predict drug efficacy, particularly suitable for constructing external comparator arms for non‐randomized controlled trials (NRCTs). This study evaluated the reliability of MBMA by comparing covariate models generated through MBMA to individual patient data.
Jiesen Yu, Ting Li, Jieren Luo, Qingshan Zheng, Lujin Li   +4 more
wiley   +1 more source

The effect of parturient height on the median effective dose of intrathecally administered ropivacaine

Annals of Saudi Medicine, 2016
BACKGROUND: Pain during cesarean delivery is one of the more common reasons for a successful medico-legal claim. However, creating an extensive block area can result in hypotension, so determining the precise dose of local anesthetic is critical ...
Xiangdi Yu, Fangxiang Zhang
doaj   +1 more source

Effect of age on the median effective dose and 95% effective dose of intravenous fentanyl for blunting the hemodynamic response to tracheal intubation: A double-blind, up-and-down sequential method trial

Journal of Anaesthesiology Clinical Pharmacology
Background and Aims: Control of the hemodynamic response during intubation is essential. To assess the effect of age on the median effective dose (ED50) and 95% effective dose (ED95) of fentanyl for blunting the hemodynamic response to intubation ...
Jatuporn Eiamcharoenwit, Phuping Akavipat   +1 more
doaj   +1 more source

Synthesis and Pharmacological Evaluation of Novel Benzenesulfonamide Derivatives as Potential Anticonvulsant Agents

Molecules, 2015
A novel series of benzenesulfonamide derivatives containing 4-aminobenzenesul-fonamide and α-amides branched valproic acid or 2,2-dimethylcyclopropanecarboxylic acid moieties were synthesized and screened for their anticonvulsant activities in mice ...
Zhiming Wang, Jinping Li, Xiao-Dong Zeng, Xian-Ming Hu, Xiaoju Zhou, Xuechuan Hong   +5 more
doaj   +1 more source

A phototaxis assay to measure sublethal effects of pesticides on bees

Scientific Reports
In agricultural areas, bees are pervasively exposed to pesticides at sublethal concentrations. Methods to establish whether these concentrations may cause negative effects are needed to assess the potential hazards of field-realistic levels of exposure ...
Gonzalo Sancho, Sergio Albacete, Celeste Azpiazu, Fabio Sgolastra, Anselm Rodrigo, Jordi Bosch   +5 more
doaj   +1 more source

ED50 of intrathecal ropivacaine for cesarean delivery with and without epidural volume extension with normal saline: a randomized controlled study.

Journal of Pain Research, 2018
M Lv,1 P Zhang,2 Z Wang3 1Department of Obestetrics and Gynecology, Affiliated Women and Children’s Hospital of Jiaxing University, Jiaxing, China; 2Department of Anesthesiology, Affiliated Women and Children’s Hospital of Jiaxing University,
Lv M, Zhang P, Wang Z
doaj  

ED50 of remimazolam combined with different doses butorphanol for first trimester artificial abortion

Frontiers in Medicine
IntroductionRemimazolam (RMZ) is a novel intravenous sedative drug of ultra-short benzodiazepine. The optimal dose of RMZ plus butorphanol for sedation during first trimester artificial abortion is unknown.
Jinming Chen, Xiaoling Li, Zilan Hu, Yuling Zheng, Ying Mai, Zhongqi Zhang   +5 more
doaj   +1 more source

Combined sedation in pediatric magnetic resonance imaging: determination of median effective dose of intranasal dexmedetomidine combined with oral midazolam

BMC Anesthesiology
Background The exact median effective dose (ED50) of intranasal dexmedetomidine combined with oral midazolam sedation for magnetic resonance imaging (MRI) examination in children remains unknow and the aim of this study was to determine the ED50 of their
Hao Xie, Jialian Zhao, Haiya Tu, Wenyang Wang, Yaoqin Hu   +4 more
doaj   +1 more source

Dose-response study of propofol combined with two different doses of esketamine for laryngeal mask airway insertion in women undergoing hysteroscopy

Heliyon
Objective: To prospectively determine the median effective dose (ED50) of propofol for inhibiting a response to laryngeal mask airway (LMA) insertion when combined with different doses of esketamine in female patients.
Yan-Jun Lin, Su-Li Chen, Xiang-Li Zheng, Shuang Yu, Liang-Yuan Lu   +4 more
doaj   +1 more source

Effect of intravenous lidocaine on the ED50 of propofol induction dose in elderly patients undergoing painless gastroscopy: a prospective, randomized, double-blinded, controlled study

Perioperative Medicine
Background Intravenous lidocaine could be a potential alternative adjuvant to propofol-based sedation for gastroscopy in elderly patients. This study aimed to evaluate the effect of intravenous lidocaine on the median effective dose (ED50) of propofol ...
Lili Tang, Wenhui Lv, Jingjing Sun, Lijian Chen   +3 more
doaj   +1 more source