Results 51 to 60 of about 7,197,670 (160)

ED50 and ED95 of Propofol Combined with Different Doses of Intravenous Lidocaine for First-Trimester Uterine Aspiration: A Prospective Dose-Finding Study Using Up-and-Down Sequential Allocation Method

Drug Design, Development and Therapy, 2022
Jingwen Zhang,1 Linglingli Kong,2 Juan Ni1 1Department of Anesthesiology, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education ...
Zhang J, Kong L, Ni J
doaj  

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Investigation of Natural Effective Gamma Dose Rates case study: Ardabil Province in Iran [PDF]

Gamma rays pose enough energy to form charged particles and adversely affect human health. Since, the external exposure of human beings to natural environmental gamma radiation normally exceeds that from all man-made sources combined, natural background ...
زیوری, سحر, صادقی, هادی, Sahar Zivari, Soheila Rahimzadeh, حضرتی, صادق, رحیم زاده, سهیلا, Manouchehr Barak, Abbas Baghi, Hadi Sadeghi, براک, منوچهر, Sadegh Hazrati, نقی زاده باقی, عباس   +11 more
core   +1 more source

Effective patient dose during neuroradiological C-arm CT procedures [PDF]

, 2013
PURPOSEWe aimed to determine the effective dose given to patients during neuroradiological C-arm computed tomography (CT) procedures.MATERIALS AND METHODSMATERIALS AND METHODSMeasurements were performed on 48 patients using a dose-area product (DAP ...
Bin Liu, Mei Bai,, Xianghua Liu,
core   +1 more source

Gender Affects the Median Effective Dose and 95% Effective Dose of Oxycodone for Blunting the Hemodynamic Response to Tracheal Intubation in Narcotic-Naïve Adult Patients

, 2018
Background: Intravenous (IV) oxycodone has been used at induction to prevent an intubation reaction. The aims of the current study were to calculate the median effective dose (ED50) and the 95% effective dose (ED95) of an IV bolus of oxycodone that ...
Ke Ha, Fang-Ping Bao, Hong-Gang Zhang, Dan-Jun Yu, Xian-Hui Kang, Qing Xie, Sheng-Mei Zhu   +6 more
core   +1 more source

Synergism of the analgesic activities of tramadol with α2 adrenoreceptor agonist xylazine in mice [PDF]

Iraqi Journal of Veterinary Sciences, 2012
The present study was undertaken to evaluate the antinociceptive interaction between tramadol and xylazine. The antinociceptive effect of intraperitoneal (I.P) administration of the drug alone or in combination was evaluated using the mouse hot-plate ...
G. A. Taqa
doaj  

Goniothalamin as a Styryl‐Lactone Toxicophore in Cancer Models: Electrophile‐Driven DNA Damage, Reactive Oxygen Species–Endoplasmic Reticulum Stress Signaling and Detoxification‐Relevant Safety Considerations

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Goniothalamin (GTN) exerts anticancer effects by promoting reactive oxygen species (ROS) generation, glutathione (GSH) depletion, DNA damage, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. These interconnected events trigger apoptosis, necroptosis, anoikis, and autophagy, while modulating mitogen‐activated protein kinase (MAPK ...
Nataša Joković, Strahinja Pešić, Marija Novaković, Anđela Dubroja Krstić, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

The median Effective Dose 50 (ED₅₀) for Potency at Lot Release and Relative Potency over 60 months for the Na-GST-1/Alhydrogel Hookworm Vaccine.

, 2017
The median Effective Dose 50 (ED50) for Potency at Lot Release and Relative Potency over 60 months for the Na-GST-1/Alhydrogel Hookworm Vaccine.
Peter J. Hotez (145727), Maria Victoria Periago (226288), Amar Jariwala (3743869), Maria Elena Bottazzi (11043), Guangzhao Li (2137420), Jeffrey M. Bethony (184528), Rodrigo Correa-Oliveira (199109), Brian P. Keegan (3743875), Pengjun Xia (3743860), Anna Yakovleva (778118), Jin Peng (287324), Doreen Campbell (3743863), David Diemert (3743866), Jordan L. Plieskatt (3743857), Jill B. Brelsford (3743872)   +14 more
core   +1 more source

Nilai Indeks Terapi Ekstrak Etanol Daun Dewa {Gynura pseudochina (Lour.) DC} dan Natrium Diklofenak pada Tikus Model Inflamasi

Majalah Kedokteran Bandung, 2012
Therapeutic index, a drug safety parameter, is comparation between the dose at which 50% animals are dead (LD50) and the dose at which 50% animals exhibit the specified effect (ED50).
Donaliazarti , Truly Sitorus, Josep I. Sigit,, Muchtan Sudjatno   +3 more
doaj   +1 more source

Comparative Toxicity of Bordeaux Mixture by Ingestion and Cuticular Contact Under Climate Change Conditions on Trichogramma cordubensis

Entomologia Experimentalis et Applicata, Volume 174, Issue 8, Page 957-967, August 2026.
In the face of environmental contamination to copper, mainly resulting from frequent copper‐based fungicide applications, it is crucial to understand the side effects of these pesticides on non‐target organisms to improve pest management. Trichogramma cordubensis, used as a biological control agent against grape berry moths in vineyards, shows strongly
William Nusillard, Tessie Garinie, Géraldine Groussier, Denis Thiéry, Jacques Frandon, Jérôme Moreau   +5 more
wiley   +1 more source