Results 61 to 70 of about 7,197,670 (160)

The median effective dose of dexmedetomidine for laryngeal mask airway insertion with propofol 2.0 mg/kg.

, 2014
BACKGROUND: Dexmedetomidine can be used as a co-induction agent to facilitate laryngeal mask airway (LMA) insertion with minimal effect on respiratory function.
Kwak, HJ, Park, KH, Min, SK, Kim, JY, Yoo, JY   +4 more
core   +1 more source

Ranking of antiseizure medications in a panel of focal seizure models predicts their comparative efficacy in clinical add‐on trials in drug‐resistant focal epilepsy

Epilepsia, Volume 67, Issue 7, Page 3719-3737, July 2026.
Abstract Objective Most antiseizure medications (ASMs) have been discovered by testing in animal models, which are generally thought to predict antiseizure activity in patients. However, it is not known whether any of these models (or a combination of models) can predict whether a novel ASM exhibits higher clinical efficacy in focal drug‐resistant ...
Wolfgang Löscher, Pavel Klein
wiley   +1 more source

CRISPR‐Cas9 Genome‐Wide Screening in Paediatric Cancer: Functional Genomics for Target Discovery and the Improvement of Existing Therapies

Medicinal Research Reviews, Volume 46, Issue 4, Page 989-1004, July 2026.
ABSTRACT CRISPR‐Cas9 genome‐wide screening has been instrumental towards identifying novel targets for drug discovery in cancer research. However, much of this research has centred specifically on adult cancers, with paediatric cancers being underserviced by current research and screening.
Steven He, Patrick Connerty, Antoine de Weck   +2 more
wiley   +1 more source

The Median Effective Dose of Ciprofol Combined with Sufentanil for Inhibiting Responses to Gastroscope Insertion in Obese Patients: A Prospective, Single-Center Study [PDF]

Zhouya Xue,1,2,* Xiang Liu,1,2,* Weisheng Qian,1 Nan Yang,1 Yongyi Pan,1 Yong Zhou,1 Wei Jiang,1 Feng Li,1 Bin Qian1 1Department of Anesthesiology, The First People’s Hospital of Yancheng, The Yancheng Clinical College of Xuzhou Medical ...
Liu X, Qian W, Pan Y, Yang N, Jiang W, Li F, Qian B, Xue Z, Zhou Y   +8 more
core  

Optimizing nicardipine dosage for effective control of pituitrin-induced hypertension in laparoscopic myomectomy undergoing total intravenous anesthesia

BMC Anesthesiology
Background This study aimed to determine the median effective dose (ED50) and 95% effective dose (ED95) of nicardipine for treating pituitrin-induced hypertension during laparoscopic myomectomy, providing guidance for the management of intraoperative ...
Chen Wang, Xiaoli Zhao, Yunyun Chen, Jianhua Xia, Xixue Zhang, Tingting Wang   +5 more
doaj   +1 more source

Non‐triazine photosystem II inhibitors provide effective control of metabolic atrazine‐resistant Amaranthus tuberculatus

Pest Management Science, Volume 82, Issue 7, Page 6864-6876, July 2026.
Metabolism‐based atrazine‐resistant Amaranthus tuberculatus populations ACR and MCR exhibit little or no cross‐resistance to amicarbazone and metribuzin, suggesting that non‐halogenated Group 5 herbicides can be utilized to re‐establish effective control.
Alexander J Lopez, Ryan S Henry, Kip E Jacobs, Damilola A Raiyemo, Isabel S Werle, Patrick J Tranel   +5 more
wiley   +1 more source

Establishing the Median and 95% Effective Doses of Oliceridine for Immediate Post-Surgical Analgesia Following Laparoscopic Cholecystectomy: A Double-Blind, Sequential Dose-Finding Study [PDF]

Xianghua Cao,1,2,* Huiling Xiao,1,2,* Haoran Yan,1,2,* Yujiao Wei,1,2 Qiting Wen,1,2 Zhijian Zhang,1,2 Guizhen Xu,1,2 Binbin Xu,1,2 Jian Chen,1,2 Xueping Li1,2 1Department of Anesthesiology, Dongguan Tungwah Hospital, Dongguan, People’s ...
Li X, Cao X, Zhang Z, Chen J, Xu B, Xiao H, Wen Q, Yan H, Wei Y, Xu G   +9 more
core  

Median effective dose of remimazolam combined with sufentanil for inhibiting laryngeal mask airway insertion responses in children of different ages [PDF]

IntroductionWe determined the median effective dose and 95% confidence interval (CI) of remimazolam required to inhibit laryngeal mask airway (LMA) insertion reactions combined with sufentanil 0.3 μg/kg in pediatric anesthesia.MethodsChildren scheduled ...
Jinxia Wang, Rong Wei, Yan Jiang, Hongyun Li   +3 more
core   +1 more source

Determination of ED50 and time to effectiveness for intrathecal hydromorphone in laboring patients using Dixon’s up-and-down sequential allocation method

BMC Anesthesiology, 2018
Background With the increasing occurrence of drug shortages, understanding the pharmacokinetics of alternative intrathecal opioid administration has gained importance.
Vikas O’Reilly-Shah, Grant C Lynde
doaj   +1 more source

A note on nonparametric estimation of the effective dose in quantal bioassay [PDF]

For the common binary response model we propose a direct method for the nonparametric estimation of the effective dose level ED? (0Binary response model,effective dose level,nonparametric regression,isotonic regression,order restricted inference,local ...
Dette, Holger, Neumeyer, Natalie, Pilz, Kay F.   +2 more
core