Results 201 to 210 of about 56,603 (238)

Predictors of lethal outcome in patients with immunoinflammatory diseases hospitalized in the intensive care unit. [PDF]

open access: yesWorld J Crit Care Med
Abramova NN   +8 more
europepmc   +1 more source

Generation of a primary culture of chick embryo enterocytes to evaluate the effects of fumonisin B1 and deoxynivalenol on cell morphology, actin filaments and nuclei. [PDF]

open access: yesPLoS One
Uribe-Rivera J   +7 more
europepmc   +1 more source

ROBUST ESTIMATION OF THE MEDIAN LETHAL DOSE

Journal of Biopharmaceutical Statistics, 2002
Alternatives to M-estimation for robust estimation of the median lethal dose in biological assays are developed. A class of link functions based on the Student-t distribution is proposed, where degrees of freedom are estimated from the data by maximum likelihood. Other alternatives include slash and finite mixture distributions.
G E, Kelly, J K, Lindsey
openaire   +2 more sources

Interval Estimation of the Median Lethal Dose

Biometrics, 1986
Assuming a logistic dose-response curve, one can construct a confidence interval for the LD50 from the asymptotic likelihood ratio test. Reasons are given for preferring this likelihood ratio interval to the established interval calculated by applying Fieller's theorem to the maximum likelihood estimates.
openaire   +3 more sources

The median lethal dose and its estimation

Archives of Toxicology, 1985
An important paper by Zbinden and Fluri-Roversi (1981) has shown the many weaknesses in any policy or regulatory system that regards an estimated LD50 in an animal species as an adequate guide to toxicity in man. The present paper draws attention to some statistical aspects of LD50 estimation that are too often neglected or misunderstood when this ...
openaire   +2 more sources

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