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ROBUST ESTIMATION OF THE MEDIAN LETHAL DOSE
Journal of Biopharmaceutical Statistics, 2002Alternatives to M-estimation for robust estimation of the median lethal dose in biological assays are developed. A class of link functions based on the Student-t distribution is proposed, where degrees of freedom are estimated from the data by maximum likelihood. Other alternatives include slash and finite mixture distributions.
G E, Kelly, J K, Lindsey
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Interval Estimation of the Median Lethal Dose
Biometrics, 1986Assuming a logistic dose-response curve, one can construct a confidence interval for the LD50 from the asymptotic likelihood ratio test. Reasons are given for preferring this likelihood ratio interval to the established interval calculated by applying Fieller's theorem to the maximum likelihood estimates.
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The median lethal dose and its estimation
Archives of Toxicology, 1985An important paper by Zbinden and Fluri-Roversi (1981) has shown the many weaknesses in any policy or regulatory system that regards an estimated LD50 in an animal species as an adequate guide to toxicity in man. The present paper draws attention to some statistical aspects of LD50 estimation that are too often neglected or misunderstood when this ...
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