Results 51 to 60 of about 1,649 (176)
Transcription‐Replication Conflicts: Unlocking New Frontiers in Cancer
BioEssays, Volume 47, Issue 8, August 2025.Transcription‐replication conflicts (TRCs) constitute a major source of genome instability. Such conflicts are regulated by chromatin, its dysfunction causing replication stress, DNA breaks, and mutations frequently found in cancer. We review the molecular basis of TRCs and chromatin regulation and discuss the clinical potential of targeting TRCs as ...
Aleix Bayona‐Feliu, Andrés Aguilera
wiley +1 more source
Omental adipose tissue is a more suitable source of canine Mesenchymal stem cells
BMC Veterinary Research, 2017 Background Mesenchymal Stem Cells (MSCs) are a promising therapeutic tool in veterinary medicine. Currently the subcutaneous adipose tissue is the leading source of MSCs in dogs.
Francisca Bahamondes +4 more
doaj +1 more source
Biological Research, 2023 Background Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a rare inherited skin disease caused by variants in the COL7A1 gene, coding for type VII collagen (C7), an important component of anchoring fibrils in the basement membrane of the epidermis.
Cristian De Gregorio +16 more
doaj +1 more source
International Endodontic Journal, Volume 58, Issue 8, Page 1126-1145, August 2025.Abstract Background Orthodontic forces may lead to neurogenic inflammation in the dental pulp by triggering the release of somatosensory neuropeptides such as Substance P (SP), Calcitonin gene‐related peptide (CGRP) and Neurokinin A (NKA). In the vast majority of patients, acute symptoms are not triggered, probably due to the control of the neurogenic ...
Javier Caviedes‐Bucheli +7 more
wiley +1 more source
Desarrollo de la Medicina Regenerativa Periodontal con células madre y hemocomponentes
Medimay, 2023 Cuba, es uno de los países con una notable aplicación de la medicina celular regenerativa, en especialidades médicas y estomatológicas, Santiago de Cuba, ha contribuido a su desarrollo, en los últimos años.
Maritza Peña Sisto +2 more
doaj
Molecular Oncology, Volume 19, Issue 4, Page 1265-1280, April 2025.Dinaciclib blocks CDK12 activity, leading to downregulation of BRCA1, and probably other proteins involved in homologous recombination, promoting nonhomologous end joining. In this scenario, the presence of ionising radiation triggers a p53‐dependent senescent response that yields increased radiosensitivity. Pan‐cyclin‐dependent‐kinase (CDK) inhibitors
Natalia García Flores +14 more
wiley +1 more source
Metabolism and signaling crosstalk in glioblastoma progression and therapy resistance
Molecular Oncology, Volume 19, Issue 3, Page 592-613, March 2025.Glioblastoma is one of the most lethal human cancers with no effective treatment nowadays. Here, we review the increasing amount of evidence supporting the connection between cell signaling deregulation and metabolic reprogramming as a key event in glioblastoma resistance to cancer therapy.
Laura Zarzuela +2 more
wiley +1 more source
Transcriptomic analysis reveals the participation of NTRC in iron homeostasis in Arabidopsis
Physiologia Plantarum, Volume 177, Issue 2, March/April 2025.Abstract NADPH‐dependent thioredoxin reductase C (NTRC) plays a central role in redox regulation of chloroplast photosynthetic metabolism. Accordingly, Arabidopsis (Arabidopsis thaliana) NTRC‐null mutants show defective photosynthetic performance and growth inhibition.
Fernando Rodríguez‐Marín +2 more
wiley +1 more source
Spontaneous Self‐Organized Order Emerging From Intrinsically Disordered Protein Polymers
WIREs Nanomedicine and Nanobiotechnology, Volume 17, Issue 1, January/February 2025.Harnessing the liquid‐liquid phase separation (LLPS) properties of intrinsically disordered protein polymers (IDPPs) enables the design and engineering of hierarchically self‐assembled protein materials with customizable structures and increasing complexity.
Sergio Acosta +4 more
wiley +1 more source