Results 51 to 60 of about 782,998 (207)

The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts

Nature Communications, 2023
Genome instability is a feature of cancer cells, transcription being an important source of DNA damage. This is in large part associated with R-loops, which hamper replication, especially at head-on transcription-replication conflicts (TRCs).
Aleix Bayona-Feliu, Emilia Herrera-Moyano, Nibal Badra-Fajardo, Iván Galván-Femenía, María Eugenia Soler-Oliva, Andrés Aguilera   +5 more
doaj   +1 more source

A Versatile Engineering Platform for the Fabrication of Prosthetic Venous Valves Using Electrospinning

Advanced Healthcare Materials, Volume 15, Issue 16, 24 April 2026.
Percutaneous prosthetic venous valves are fabricated by embedding stents in an electrospun matrix that extends luminally to form leaflets. The design shields leaflets from hyperplastic cells, isolates struts from blood contact, and avoids discrete anchoring points.
Dario Arcuti, Salma Mansi, Dominic Biebl, Malin Reuter, Maximilian Grab, José Carlos Rodríguez‐Cabello, Petra Mela   +6 more
wiley   +1 more source

Enzymatic Poly(gallic acid)‐grafted L‐Histidine Reduces Cell Inflammation and Oxidative Stress: In Silico and In Vitro Studies

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
Microwave‐assisted grafting yields a PGAL–His conjugate with enhanced binding through electrostatic and hydrogen‐bond interactions. The material modulates THP‐1 macrophage response, reducing ROS production, pro‐inflammatory cytokines (IL‐6, IL‐1β, TNF‐α), and cell adhesion.
Carmen G. Hernández‐Valencia, Iris N. Serratos, Carlos M. Torre‐Morales, Rosa Isela Ortiz‐Huidobro, Alfredo Vázquez, José Pedraza‐Chaverri, Valentín Martínez‑López, Javier Fernández‑Torres, Roberto Sánchez‑Sánchez, Yessica Zamudio‑Cuevas, Miquel Gimeno   +10 more
wiley   +1 more source

Prolonged Release of IL‐10 From Enzyme‐Mediated Poly‐l‐(Tyrosine‐co‐Phenylalanine) Nanocrystals Enhances Stability and Modulates Inflammatory Responses

Biopolymers, Volume 117, Issue 2, March 2026.
Schematic representation of enzyme‐mediated peptide nanocrystal formation and IL‐10 encapsulation, providing stabilized and sustained cytokine delivery that modulates macrophage phenotype and reduces inflammatory responses. ABSTRACT Protease‐catalyzed synthesis of a peptide composed of l‐tyrosine and l‐phenylalanine (2.2:1 M ratio) was achieved in a ...
Fátima Landa‐Tencle, Carmen G. Hernández‐Valencia, Fernando Guzmán‐Lagunes, Carmina Montiel, Yoan Cuellar‐Entenza, Carlos Guerrero‐Sánchez, Steffi Stumpf, Stephanie Hoeppener, Ulrich S. Schubert, Yessica Zamudio‐Cuevas, Roberto Sánchez‐Sánchez, Miquel Gimeno   +11 more
wiley   +1 more source

Mineralizing Elastin‐Like Protein Microgels

Journal of Biomedical Materials Research Part A, Volume 113, Issue 12, December 2025.
ABSTRACT Mineralized tissues, such as bone and enamel are fundamental to the structure and function of organisms, with a complex interplay between their organic and inorganic components. Organized mineralization is crucial for both the tissues of living organisms and engineered materials.
Ieva Sapjanskaite, Abshar Hasan, José Carlos Rodríguez‐Cabello, Christopher Parmenter, Michael W. Fay, Christabel Fowler, Cameron Alexander, Alvaro Mata   +7 more
wiley   +1 more source

La medicina genómica un cambio de paradigma de la medicina moderna. Retos para la bioética y el derecho

Revista Latinoamericana de Bioética, 2011
La medicina genómica y sus diferentes formas de aplicación medicinas personalizada o individualizada, de la que hacen parte la farmacogenómica, toxicogenómica y nutrigenómica; y la medicina predictiva, regenerativa o de reemplazo, molecular y ...
Ana Isabel Gómez Córdoba
doaj   +3 more sources

Intranasal mesenchymal stem cell secretome administration markedly inhibits alcohol and nicotine self-administration and blocks relapse-intake: mechanism and translational options

Stem Cell Research & Therapy, 2019
Background Chronic consumption of most drugs of abuse leads to brain oxidative stress and neuroinflammation, which inhibit the glutamate transporter GLT-1, proposed to perpetuate drug intake.
María Elena Quintanilla, Fernando Ezquer, Paola Morales, Daniela Santapau, Pablo Berríos-Cárcamo, Marcelo Ezquer, Mario Herrera-Marschitz, Yedy Israel   +7 more
doaj   +1 more source

Adaptive Elastin‐Like Hydrogel with Unidirectional and Controllable Anisotropic Actuation for Soft Robotics and Tissue Engineering

Advanced Materials Technologies, Volume 10, Issue 17, September 4, 2025.
Fiber‐reinforced elastin‐like tubular scaffolds are engineered to achieve anisotropic and reversible actuation under external stimuli. By adjusting fiber's angle, actuation behavior is finely tuned, enabling distinct actuation responses, even within different regions of the same scaffold.
Federica Sallustio, Amanda Schmidt, Ikram El Maachi, Alexander Greenhalgh, Martin Frydrych, Stefan Jockenhoevel, José Carlos Rodríguez‐Cabello, Alicia Fernández‐Colino   +7 more
wiley   +1 more source

Medicina regenerativa en ciencias estéticas y cirugía plástica

, 2012
La medicina regenerativa ha dejado muchas satisfacciones porque los factores de crecimiento plaquetario es una alternativa terapéutica autóloga siendo muy beneficioso por su ...
Hernández, Rossani
core   +1 more source

Maintenance of chronicity signatures in fibroblasts isolated from recessive dystrophic epidermolysis bullosa chronic wound dressings under culture conditions

Biological Research, 2023
Background Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a rare inherited skin disease caused by variants in the COL7A1 gene, coding for type VII collagen (C7), an important component of anchoring fibrils in the basement membrane of the epidermis.
Cristian De Gregorio, Evelyng Catalán, Gabriel Garrido, Pilar Morandé, Jimena Castillo Bennett, Catalina Muñoz, Glenda Cofré, Ya-Lin Huang, Bárbara Cuadra, Paola Murgas, Margarita Calvo, Fernando Altermatt, María Joao Yubero, Francis Palisson, Andrew P. South, Marcelo Ezquer, Ignacia Fuentes   +16 more
doaj   +1 more source