Results 191 to 200 of about 349,116 (315)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Synthetic Approaches, Properties, and Applications of Acylals in Preparative and Medicinal Chemistry. [PDF]

Molecules
Keydel T, Link A.
europepmc   +1 more source

Pierre Potier Outstanding Contribution in the Area of Medicinal Chemistry

, 2004
Yuichi Kanaoka
openalex   +1 more source

The roles and applications of extracellular vesicles in cancer

Molecular Oncology, EarlyView.
Extracellular vesicles (EVs) are minute versions of cells limited by a lipid bilayer containing cytoplasm from the cell that releases them, but without a nucleus and thus unable to self‐reproduce. EVs contain multiple molecules (proteins, lipids, glycans, and nucleic acids) they can induce complex responses in cells.
Clotilde Théry, Daniel Louvard
wiley   +1 more source

Introduction to 'Medicinal Chemistry Small Molecule Probes'. [PDF]

RSC Chem Biol
Nixon G, Rahman KM, Spencer J.
europepmc   +1 more source

Natural Products-Pyrazine Hybrids: A Review of Developments in Medicinal Chemistry. [PDF]

Molecules, 2023
Chen GQ, Guo HY, Quan ZS, Shen QK, Li X, Luan T.   +5 more
europepmc   +1 more source

Medicinal Chemistry: Defining Itself [PDF]

, 2008
Rainer Metternich, Giorgio Tarzia
openalex   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Curcumin Derivatives in Medicinal Chemistry: Potential Applications in Cancer Treatment. [PDF]

Molecules
Kuzminska J, Szyk P, Mlynarczyk DT, Bakun P, Muszalska-Kolos I, Dettlaff K, Sobczak A, Goslinski T, Jelinska A.   +8 more
europepmc   +1 more source

Developments in the chemistry of selenaheterocyclic compounds of practical importance in synthesis and medicinal biology

, 2006
Jacek Młochowski, Krystian Kloc, Rafał Lisiak, Piotr Potaczek, Halina Wójtowicz   +4 more
openalex   +2 more sources