Results 191 to 200 of about 390,146 (300)

From Patterns to Pills: How Informatics Is Shaping Medicinal Chemistry. [PDF]

Pharmaceutics
Trachtenberg A, Akabayov B.
europepmc   +1 more source

Computational Methods in Medicinal Chemistry : Mechanistic Investigations and Virtual Screening Development

, 2015
Fredrik Svensson
openalex   +1 more source

Medicinal Resources, Natural Products Chemistry [PDF]

, 2007
アワレ スレス, 手塚 康弘, 門田 重利   +2 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Implementing a Functional Group Analysis Activity to Support Student Learning in Medicinal Chemistry: A Three-Year Experience. [PDF]

Pharmacy (Basel)
Belani A, Belani JD.
europepmc   +1 more source

Development of Novel and Distinctive Biologically Active Compounds Using a Wide Variety of Elements: Exploring the Elements-based Chemical Space for Medicinal Chemistry

Shinya Fujii
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Exploring Subtilisin Inhibition to Discover Antimalarial Drugs: Insights into Medicinal Chemistry and Drug Discovery. [PDF]

Pharmaceuticals (Basel)
Cochicho Leonardo M, Albino SL, de Araújo WJS, Nascimento MVB, Rodríguez-Macías JD, Brazon EAM, Moura RO, Nogueira F, Nascimento IJDS.   +8 more
europepmc   +1 more source

A medicinal chemistry approach to drug repositioning in the treatment of tuberculosis and malaria

, 2016
Gurminder Kaur
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source