Results 31 to 40 of about 389,662 (300)
Click Reactions in Medicinal Chemistry
Pharmaceuticals, 2023 Two decades after K [...]
Damien Bosc
doaj +1 more source
Lithiation of 4-membered heterocycles as useful strategy for the preparation of new molecular scaffolds: addressing the regioselectivity in azetidines and thietanes [PDF]
, 2013 Four-membered heterocycles (4-MH) with one or two heteroatoms are of great importance in medicinal chemistry and synthetic organic chemistry. This kind of scaffolds show peculiar structural features, related to the ring “puckering”, and biological ...
Carroccia, Laura +7 more
core
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–2
Molecules, 2017 Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials, which are published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules [...]
Diego Muñoz-Torrero +16 more
doaj +1 more source
Medicinal Chemistry of Aminocyclitols
Current Medicinal Chemistry, 2010 Aminocyclitols comprise an important group of compounds with remarkable biological activities. From a structural standpoint, aminocyclitols are amino polyhydroxy cycloalkanes that can be found in nature in several families of natural products. Among them, the aminoglycoside antibiotics, since the discovery of streptomycin, have become particularly ...
Díaz-Bueno, Lucía +1 more
openaire +3 more sources
Medicinal Chemistry for 2020 [PDF]
Future Medicinal Chemistry, 2011 Rapid advances in our collective understanding of biomolecular structure and, in concert, of biochemical systems, coupled with developments in computational methods, have massively impacted the field of medicinal chemistry over the past two decades, with even greater changes appearing on the horizon.
Seetharama D, Satyanarayanajois +1 more
openaire +2 more sources
Room Temperature Synthesis and Antibacterial Activity of New Sulfonamides Containing N,N -Diethyl-Substituted AmidoMoieties [PDF]
, 2012 Sulfonamide drugs which have brought about an antibiotic revolution in medicine are associated with a wide range of biological activities.
Ajani, Olayinka O. +4 more
core +5 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Perspective in Medicinal Chemistry
Current Topics in Medicinal Chemistry, 2019 “Perspective in Medicinal Chemistry” aims to cover all the latest outstanding developments of medicinal chemistry applied to dentistry. This new journal will describe recent research and developments in the field of medicinal chemistry and ...
openaire +2 more sources