Results 31 to 40 of about 1,547,751 (329)

The Essential Medicinal Chemistry of Curcumin

Journal of Medicinal Chemistry, 2017
Curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation.
Kathryn M. Nelson, Jayme L. Dahlin, J. Bisson, J. Graham, G. Pauli, M. Walters   +5 more
semanticscholar   +1 more source

The chemistry of snake venom and its medicinal potential

Nature Reviews Chemistry, 2022
The fascination and fear of snakes dates back to time immemorial, with the first scientific treatise on snakebite envenoming, the Brooklyn Medical Papyrus, dating from ancient Egypt. Owing to their lethality, snakes have often been associated with images
Ana L. Oliveira, M. Viegas, S. L. Da Silva, A. Soares, M. Ramos, P. Fernandes   +5 more
semanticscholar   +1 more source

Click Reactions in Medicinal Chemistry

Pharmaceuticals, 2023
Two decades after K [...]
Damien Bosc
doaj   +1 more source

Fragment-to-Lead Medicinal Chemistry Publications in 2020

Journal of Medicinal Chemistry, 2021
Fragment-based drug discovery (FBDD) continues to evolve and make an impact in the pharmaceutical sciences. We summarize successful fragment-to-lead studies that were published in 2020. Having systematically analyzed annual scientific outputs since 2015,
I. D. de Esch, D. Erlanson, W. Jahnke, Christopher N. Johnson, Louise Walsh   +4 more
semanticscholar   +1 more source

Sulfoximines as Rising Stars in Modern Drug Discovery? Current Status and Perspective on an Emerging Functional Group in Medicinal Chemistry.

Journal of Medicinal Chemistry, 2020
Sulfoximines have been largely disregarded in medicinal chemistry for a long time. However, recently, they have risen to the apparent level of stardom on the drug discovery scene.
P. Mäder, L. Kattner
semanticscholar   +1 more source

New trends for metal complexes with anticancer activity [PDF]

, 2008
Medicinal inorganic chemistry can exploit the unique properties of metal ions for the design of new drugs. This has, for instance, led to the clinical application of chemotherapeutic agents for cancer treatment, such as cisplatin. The use of cisplatin is,
Ang, Ang, Barnard, Barnes, Bednarski, Bergamo, Bregman, Calderone, Casini, Debreczeni, Dixon, Dyson, Failes, Feazell, Guo, Habtemariam, Hall, Hambley, Hannon, Harris, Heringova, Hillard, Hotze, James, Jung, Komeda, Liu, Lutterman, MacDiarmid, Mackay, Mackay, McNae, Meggers, Milacic, Noor, Oleksi, Orvig, Ott, Pascu, Peacock, Peter J Sadler, Pieter CA Bruijnincx, Reed, Schatzschneider, Schlawe, Scolaro, Smalley, Sun, Thompson, Timerbaev, Urig, Urig, van Zutphen, Wang, Weidt, Yan, Yang   +56 more
core   +1 more source

The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma. [PDF]

, 2014
Blocking the bioactivity of allergens is conceptually attractive as a small-molecule therapy for allergic diseases but has not been attempted previously.
Anandan C., Arbes S. J., Asokananthan N., Billson J., Boyd M. J., Brown A., Brown A. D., Chan W. C., Chen J. C., Clive Robinson, Comoy E. E., David R. Garrod, Fattouh R., Gary K. Newton, Gelber L. E., Gough L., Jahnsen F. L., Jie Chen, Jihui Zhang, Jonathan P. Richardson, Kerry Jenkins, King C., Liu H., Marcaccini S., Mark R. Stewart, Meriel R. Major, Milan D. S., Moffatt M. F., Möller G. M., Nicola J. Francis-Newton, Peat J. K., Peat J. K., Pei Lai, Pichavant M., Platts-Mills T. A., Platts-Mills T. A., Platts-Mills T. A. E., Platts-Mills T. A. E., Prefontaine D., Purello-D’Ambrosia F., Rebekah E. Key, Robinson C., Silvestri M., Smith J. M., Sporik R., Squillace S. P., Steven M. Lloyd, Stewart G. A., Stuart Firth-Clark, Takai T., Trevor R. Perrior, Wan H., Ying S., Zhang J., Zhang J., Zhang J., Zhang J.   +56 more
core   +7 more sources

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–2

Molecules, 2017
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials, which are published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules [...]
Diego Muñoz-Torrero, Arduino A. Mangoni, Hong Liu, Christopher Hulme, Jarkko Rautio, Rafik Karaman, Maria Emília de Sousa, Katalin Prokai-Tatrai, Jean-Marc Sabatier, Carlo Siciliano, F. Javier Luque, George Kokotos, Rino Ragno, Simona Collina, Catherine Guillou, Michael Gütschow, Luigi A. Agrofoglio   +16 more
doaj   +1 more source

Current and Future Roles of Artificial Intelligence in Medicinal Chemistry Synthesis

Journal of Medicinal Chemistry, 2020
Artificial intelligence and machine learning have demonstrated their potential role in predictive chemistry and synthetic planning of small molecules; there are at least a few reports of companies employing in silico synthetic planning into their overall
Thomas J. Struble, Juan Alvarez, Scott P. Brown, M. Chytil, Justin S Cisar, R. DesJarlais, O. Engkvist, S. Frank, D. Greve, Daniel J. Griffin, Xinjun Hou, J. Johannes, Constantine Kreatsoulas, B. Lahue, M. Mathea, Georg Mogk, C. Nicolaou, Andrew Palmer, D. J. Price, Richard I. Robinson, Sebastian Salentin, Li Xing, T. Jaakkola, W. Green, R. Barzilay, Connor W. Coley, K. Jensen   +26 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source