Results 31 to 40 of about 1,354,772 (332)
Scientific Reports, 2017 To be effective as a drug, a potent molecule must reach its target in the body in sufficient concentration, and stay there in a bioactive form long enough for the expected biologic events to occur.
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Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules
Journal of Medicinal Chemistry, 2022 Major advances have recently defined functions for human mono-ADP-ribosylating PARP enzymes (mono-ARTs), also opening up potential applications for targeting them to treat diseases.
Maria Giulia Nizi +3 more
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Chemical Reviews, 2021 The glycocalyx, a thick layer of carbohydrates, surrounds the cell wall of most bacterial and parasitic pathogens. Recognition of these unique glycans by the human immune system results in destruction of the invaders.
P. Seeberger
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Introduction to the themed collection on ‘AI in Medicinal Chemistry’ [PDF]
RSC Med ChemJian Zhang +2 more
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Hydroxamic Acid Derivatives: From Synthetic Strategies to Medicinal Chemistry Applications
ACS Omega, 2021 Since the approval of three hydroxamic acid-based HDAC inhibitors as anticancer drugs, such functional groups acquired even more notoriety in synthetic medicinal chemistry.
A. Citarella +4 more
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Epigenetic Medicinal Chemistry [PDF]
ACS Medicinal Chemistry Letters, 2015 The past decade has seen tremendous growth in our understanding of epigenetics and chromatin remodeling. Small, organic molecule modulators of a number of chromatin modifying proteins (CMPs) have been reported over this time frame and several of these have advanced to human clinical trials.
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Looking back and moving forward in medicinal chemistry
Nature Communications, 2023 Medicinal chemistry is a fast-evolving interdisciplinary research area which aims to improve human life by developing drugs to combat diseases. Nature Communications interviewed three scientists, Daniele Castagnolo (Associate Professor at University ...
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RSC Medicinal Chemistry, 2021 Urea and thiourea represent privileged structures in medicinal chemistry. Indeed, these moieties constitute a common framework of a variety of drugs and bioactive compounds endowed with a broad range of therapeutic and pharmacological properties. Herein,
Riccardo Ronchetti +4 more
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Open Medicinal Chemistry [PDF]
ChemMedChem, 2018 Hello 2019! ChemMedChem Editor David Peralta looks back at the journal's activities in 2018, as well as upcoming Special Collections, features, and developments for ChemPubSoc Europe in 2019. He also introduces the journal's new Editorial Board co-chair, Prof. Sangyong Jon from the Korea Advanced Institute of Science and Technology (KAIST).
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Put a ring on it: application of small aliphatic rings in medicinal chemistry.
RSC Medicinal Chemistry, 2021 Aliphatic three- and four-membered rings including cyclopropanes, cyclobutanes, oxetanes, azetidines and bicyclo[1.1.1]pentanes have been increasingly exploited in medicinal chemistry for their beneficial physicochemical properties and applications as ...
M. Bauer +6 more
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