Results 71 to 80 of about 6,236 (217)

Analysis of MEFV exon methylation and expression patterns in familial Mediterranean fever

BMC Medical Genetics, 2011
Background MEFV mutations and decreased expression level of the gene are related to FMF pathology. DNA methylation at CpG islands is a well-known mechanism for transcriptional silencing.
Ozdogan Huri, Hatemi Gulen, Celikyapi Erdem Gokce, Arisoy Nil, Kasapcopur Ozgur, Kirectepe Asli K, Tahir Turanli Eda   +6 more
doaj   +1 more source

Genetic loss of murine pyrin, the Familial Mediterranean Fever protein, increases interleukin-1β levels. [PDF]

PLoS ONE, 2012
Familial Mediterranean Fever (FMF) is an inherited autoinflammatory disorder characterized by unprovoked episodes of fever and inflammation. The associated gene, MEFV (Mediterranean Fever), is expressed primarily by cells of myeloid lineage and encodes ...
Pamela R Hesker, MyTrang Nguyen, Martina Kovarova, Jenny P-Y Ting, Beverly H Koller   +4 more
doaj   +1 more source

A Narrative Review on Integrative Bioinformatics Approaches for microRNA Research in Familial Mediterranean Fever: Current Insights and Future Directions

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Familial Mediterranean Fever (FMF) is a monogenic autoinflammatory disease caused by mutations in the MEFV gene, resulting in recurrent inflammatory episodes and a risk of developing amyloidosis. Although its pathophysiology is well described, FMF still lacks specific biomarkers and personalized treatment strategies ...
Zeinab Skaineh, Razane Hammoud, Ahlam Chaaban, Eliana Eldawra, José‐Noel Ibrahim   +4 more
wiley   +1 more source

Common MEFV Mutations in Palestinian Patients with Familial Mediterranean Fever [PDF]

, 2015
Familial Mediterranean fever (FMF) is an autosomal recessive inflammatory disorder caused by mutations in the MEFV gene that encodes the pyrin protein. The disease is relatively common among people originating from the Mediterranean areas.
Ashour, Mohammed J., Sharif, Fadel A.
core  

A Brain‐Targeting Curcumin Analog Inhibits Glioblastoma Progression Through THBS1/TGF‐β1/PI3K–AKT Axis Modulation: Evidence From Experimental and Bioinformatic Analyses

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Glioblastoma (GBM) is the most aggressive primary brain tumour, associated with a dismal prognosis and an urgent need for innovative therapeutic strategies. To address this challenge, our group developed DMC‐GF, a novel brain‐targeted curcumin analog engineered to enhance blood–brain barrier permeability by blocking metabolic sites and ...
Zijian Han, Xuetao Li, Yang Zhu, Zhimin Wang, Yingbo Hou, Huiling Tao, Meng Ma, Xiangtong Xie, HaiYang Zhang   +8 more
wiley   +1 more source

Evaluation of Familial Mediterranean Fever Patients in Sivas in Terms of MEFV Gene Mutations

, 2023
Objective: Familial Mediterranean Fever is an autosomal recessive autoinflammatory multisystemic genetic disease caused by mutations in the MEFV gene.
Abdussamed Yasin DEMİR, Demir, Abdussamed Yasin, Ömer YAKAR, Yakar, Ömer   +3 more
core   +1 more source

TNF Inhibitor Therapy in Corticosteroid‐Resistant or ‐Dependent Pediatric Neutrophilic Dermatosis

Pediatric Dermatology, Volume 43, Issue 2, Page 373-377, March/April 2026.
ABSTRACT Neutrophilic dermatoses are rare in children. Systemic corticosteroids are the first‐line treatment, but guidelines for second‐line therapies are lacking. We report five cases of children with systemic steroid‐resistant/dependent neutrophilic dermatoses, successfully treated with tumor necrosis factor inhibitors.
Laure Chêne, Thomas Hubiche, Jean‐Marie De Guillebon, Maella Severino‐Freire, Emmanuelle Bourrat, Sébastien Barbarot, Alice Phan, Christine Chiaverini   +7 more
wiley   +1 more source

Frequencies of the Common Mefv Gene Mutations in Adiyaman, Southeast Anatolia, Turkey

Balkan Journal of Medical Genetics, 2014
Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by fever and serosal inflammation. The reasons for the disorder are mutations in the Mediterranean fever (MEFV) gene; the most common of which are M694V, M680I, M694I and
Korkmaz D. T., Atak P. G., Çelik Ç.
doaj   +1 more source

Unusual presentation of familial Mediterranean fever with co‐existing polyarteritis nodosa and acute post‐streptococcal glomerulonephritis

Clinical Case Reports, 2022
Acute post‐streptococcal glomerulonephritis (APSGN) and polyarteritis nodosa (PAN) may occur simultaneously after streptococcal infection in a child who is previously healthy but carries a Mediterranean fever (MEFV) mutation.
Yeşim Özdemir Atikel, Betül Emine Derinkuyu, Sevcan A. Bakkaloğlu   +2 more
doaj   +1 more source

MEFV mutations in Northwest of Iran: a cross sectional study.

Iranian journal of basic medical sciences, 2015
Familial Mediterranean Fever (FMF) is an autosomal recessive disorder characterized by recurrent episodes of fever accompanied by peritonitis, pleurisy, and arthritis. FMF affects mainly Mediterranean populations and is caused by mutations in the familial Mediterranean fever (MEFV) gene.
Jabbarpour Bonyadi, Morteza, Najd Gerami, Sousan Mir, Somi, Mohammad Hossein, Dastgiri, Saeed   +3 more
openaire   +3 more sources