Results 11 to 20 of about 34,194 (287)

CD45 expression discriminates waves of embryonic megakaryocytes in the mouse [PDF]

Haematologica, 2019
Embryonic megakaryopoiesis starts in the yolk sac on gestational day 7.5 as part of the primitive wave of hematopoiesis, and it continues in the fetal liver when this organ is colonized by hematopoietic progenitors between day 9.5 and 10.5, as the ...
Isabel Cortegano, Natalia Serrano, Carolina Ruiz, Mercedes Rodríguez, Carmen Prado, Mario Alía, Andrés Hidalgo, Eva Cano, Belén de Andrés, María-Luisa Gaspar   +9 more
doaj   +2 more sources

Transcription factor 3 is dysregulated in megakaryocytes in myelofibrosis

Platelets
Transcription factor 3 (TCF3) is a DNA transcription factor that modulates megakaryocyte development. Although abnormal TCF3 expression has been identified in a range of hematological malignancies, to date, it has not been investigated in myelofibrosis ...
Ryan J Collinson, Lynne Wilson, Darren Boey, Zi Yun Ng, Bob Mirzai, Hun S Chuah, Rebecca Howman, Carolyn S Grove, Jacques A J Malherbe, Michael F Leahy, Matthew D Linden, Kathryn A Fuller, Wendy N Erber, Belinda B Guo   +13 more
doaj   +2 more sources

Role of platelets and megakaryocytes in adaptive immunity

Platelets, 2021
The immune system is comprised of two principal interconnected components called innate and adaptive immunity. While the innate immune system mounts a nonspecific response that provides protection against the spread of foreign pathogens, the adaptive ...
Genevieve Marcoux, Audrée Laroche, Jenifer Espinoza Romero, Eric Boilard   +3 more
doaj   +2 more sources

CD34+ megakaryocytes and megakaryocytic fragments in myelodysplastic syndrome [PDF]

Blood, 2017
![Figure][1] A 65-year-old woman presented with fatigue and exertional dyspnea. The peripheral blood showed: hemoglobin, 91 g/L; leukocytes, 4.8 × 109/L with 1% blast cells; and platelets, 35 × 109/L with megakaryocytic fragments (panel A, filled black arrow; original magnification ×100;
Yan, Chen, Hong, Chang
openaire   +2 more sources

Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death [PDF]

, 2003
Caspase-directed apoptosis usually fragments cells, releasing nonfunctional, prothrombogenic, membrane-bound apoptotic bodies marked for rapid engulfment by macrophages.
Jones, David B., Simon B. Brown, Brown, Simon B, Murray C.H. Clarke, David B. Jones, Savill, John, Brendon S. Noble, Clarke, Murray C H, Noble, Brendon S, John Savill   +9 more
core   +1 more source

282. Megakaryocytes morphology in idiopathic (primary) myelofibrosis [PDF]

, 2003
Idiopathic myelofibrosis (IMF) is a hematopoietic stem cell disorder with hypercellular bone marrow and an increase in abnormal megakaryocytes, varying degrees of marrow fibrosis, and extramedullary hematopoiesis.
Byelinska, I.V., Kabachenko, I.N., I.N. Kabachenko, Dyagil, I.S., I.S. Dyagil, I.V. Byelinska   +5 more
core   +1 more source

The duplication mutation of Quebec platelet disorder dysregulates PLAU, but not C10orf55, selectively increasing production of normal PLAU transcripts by megakaryocytes but not granulocytes. [PDF]

PLoS ONE, 2017
Quebec Platelet disorder (QPD) is a unique bleeding disorder that markedly increases urokinase plasminogen activator (uPA) in megakaryocytes and platelets but not in plasma or urine.
Catherine P M Hayward, Minggao Liang, Subia Tasneem, Asim Soomro, John S Waye, Andrew D Paterson, Georges E Rivard, Michael D Wilson   +7 more
doaj   +1 more source

Climacteric Lowers Plasma Levels of Platelet-Derived Microparticles: A Pilot Study in Pre-versus Postmenopausal Women [PDF]

, 2012
Background: Climacteric increases the risk of thrombotic events by alteration of plasmatic coagulation. Up to now, less is known about changes in platelet-(PMP) and endothelial cell-derived microparticles (EMP). Methods: In this prospective study, plasma
Erhard Hiller, Sabine Roesner, Toth, Bettina, Katharina Nikolajek, Nikolajek, Katharina, Andreas Rank, Rank, Andreas, Nieuwland, Rienk, Hiller, Erhard, Rösner, Sabine, Roesner, Sabine, Bettina Toth, Rienk Nieuwland   +12 more
core   +1 more source

Enhancing functional platelet release in vivo from in vitro–grown megakaryocytes using small molecule inhibitors

Blood Advances, 2018
: In vitro–grown megakaryocytes for generating platelets may have value in meeting the increasing demand for platelet transfusions. Remaining challenges have included the poor yield and quality of in vitro–generated platelets. We have shown that infusing
Danuta Jarocha, Karen K. Vo, Randolph B. Lyde, Vincent Hayes, Rodney M. Camire, Mortimer Poncz   +5 more
doaj   +1 more source

Composition and synthesis of glycolipids in megakaryocytes and platelets: differences in synthesis in megakaryocytes at different stages of maturation

Journal of Lipid Research, 1990
The composition and synthesis of megakaryocyte and platelet glycolipids were compared since these lipids are thought to be important for biologic activities such as adhesion and maturation. Highly purified guinea pig megakaryocytes at different stages of
PK Schick, XL He
doaj   +1 more source