Results 11 to 20 of about 28,036 (235)
Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint
Haematologica, 2016 Megakaryocytes are naturally polyploid cells that increase their ploidy by endomitosis. However, very little is known regarding the mechanism by which they escape the tetraploid checkpoint to become polyploid.
Anita Roy +11 more
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The duplication mutation of Quebec platelet disorder dysregulates PLAU, but not C10orf55, selectively increasing production of normal PLAU transcripts by megakaryocytes but not granulocytes. [PDF]
PLoS ONE, 2017 Quebec Platelet disorder (QPD) is a unique bleeding disorder that markedly increases urokinase plasminogen activator (uPA) in megakaryocytes and platelets but not in plasma or urine.
Catherine P M Hayward +7 more
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Blood Advances, 2018 : In vitro–grown megakaryocytes for generating platelets may have value in meeting the increasing demand for platelet transfusions. Remaining challenges have included the poor yield and quality of in vitro–generated platelets. We have shown that infusing
Danuta Jarocha +5 more
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Journal of Lipid Research, 1990 The composition and synthesis of megakaryocyte and platelet glycolipids were compared since these lipids are thought to be important for biologic activities such as adhesion and maturation. Highly purified guinea pig megakaryocytes at different stages of
PK Schick, XL He
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Culture of Megakaryocytes from Human Peripheral Blood Mononuclear Cells
Bio-Protocol, 2015 Megakaryocytes are the precursor cells of platelets and are bona fide resident cells in the bone marrow but extremely low in numbers (~1% of total nucleated cells).
Vishal Salunkhe +2 more
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Macedonian Veterinary Review, 2019 Emperipolesis is considered a physiological phenomena often present in various pathophysiological conditions, but its etiology is still unknown. In this study, we analyzed the number of megakaryocytes and the percentage of emperipoletic cells in the ...
Damir Suljević +2 more
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CD45 expression discriminates waves of embryonic megakaryocytes in the mouse
Haematologica, 2019 Embryonic megakaryopoiesis starts in the yolk sac on gestational day 7.5 as part of the primitive wave of hematopoiesis, and it continues in the fetal liver when this organ is colonized by hematopoietic progenitors between day 9.5 and 10.5, as the ...
Isabel Cortegano +9 more
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Dual role of IL-21 in megakaryopoiesis and platelet homeostasis
Haematologica, 2017 Gene profiling studies have indicated that in vitro differentiated human megakaryocytes express the receptor for IL-21 (IL-21R), an immunostimulatory cytokine associated with inflammatory disorders and currently under evaluation in cancer therapy.
Salima Benbarche +7 more
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CXCR4high megakaryocytes regulate host-defense immunity against bacterial pathogens
eLife, 2022 Megakaryocytes (MKs) continuously produce platelets to support hemostasis and form a niche for hematopoietic stem cell maintenance in the bone marrow.
Jin Wang +7 more
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Changes in Megakaryocytes in Cases of Thrombocytopenia: Bone Marrow Aspiration and Biopsy Analysis [PDF]
Journal of Clinical and Diagnostic Research, 2013 Background: Thrombocytopenia (platelet counts less than 150,000/μl) is commonly encountered in various hematological disorders including myelodysplastic syndromes as well as various non-myelodysplastic hematological conditions.
Tejinder Singh Bhasin +6 more
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