Results 11 to 20 of about 27,974 (255)

CD34+ megakaryocytes and megakaryocytic fragments in myelodysplastic syndrome [PDF]

Blood, 2017
![Figure][1] A 65-year-old woman presented with fatigue and exertional dyspnea. The peripheral blood showed: hemoglobin, 91 g/L; leukocytes, 4.8 × 109/L with 1% blast cells; and platelets, 35 × 109/L with megakaryocytic fragments (panel A, filled black arrow; original magnification ×100;
Yan, Chen, Hong, Chang
openaire   +2 more sources

The duplication mutation of Quebec platelet disorder dysregulates PLAU, but not C10orf55, selectively increasing production of normal PLAU transcripts by megakaryocytes but not granulocytes. [PDF]

PLoS ONE, 2017
Quebec Platelet disorder (QPD) is a unique bleeding disorder that markedly increases urokinase plasminogen activator (uPA) in megakaryocytes and platelets but not in plasma or urine.
Catherine P M Hayward, Minggao Liang, Subia Tasneem, Asim Soomro, John S Waye, Andrew D Paterson, Georges E Rivard, Michael D Wilson   +7 more
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Enhancing functional platelet release in vivo from in vitro–grown megakaryocytes using small molecule inhibitors

Blood Advances, 2018
: In vitro–grown megakaryocytes for generating platelets may have value in meeting the increasing demand for platelet transfusions. Remaining challenges have included the poor yield and quality of in vitro–generated platelets. We have shown that infusing
Danuta Jarocha, Karen K. Vo, Randolph B. Lyde, Vincent Hayes, Rodney M. Camire, Mortimer Poncz   +5 more
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Composition and synthesis of glycolipids in megakaryocytes and platelets: differences in synthesis in megakaryocytes at different stages of maturation

Journal of Lipid Research, 1990
The composition and synthesis of megakaryocyte and platelet glycolipids were compared since these lipids are thought to be important for biologic activities such as adhesion and maturation. Highly purified guinea pig megakaryocytes at different stages of
PK Schick, XL He
doaj   +1 more source

Culture of Megakaryocytes from Human Peripheral Blood Mononuclear Cells

Bio-Protocol, 2015
Megakaryocytes are the precursor cells of platelets and are bona fide resident cells in the bone marrow but extremely low in numbers (~1% of total nucleated cells).
Vishal Salunkhe, Petros Papadopoulos, Laura Gutiérrez   +2 more
doaj   +1 more source

Emperipolesis: Sternal and femoral microenvironment induces megakaryiocyte emperipolesis in the Wistar strain

Macedonian Veterinary Review, 2019
Emperipolesis is considered a physiological phenomena often present in various pathophysiological conditions, but its etiology is still unknown. In this study, we analyzed the number of megakaryocytes and the percentage of emperipoletic cells in the ...
Damir Suljević, Filip Filipić, Erna Islamagić   +2 more
doaj   +1 more source

CD45 expression discriminates waves of embryonic megakaryocytes in the mouse

Haematologica, 2019
Embryonic megakaryopoiesis starts in the yolk sac on gestational day 7.5 as part of the primitive wave of hematopoiesis, and it continues in the fetal liver when this organ is colonized by hematopoietic progenitors between day 9.5 and 10.5, as the ...
Isabel Cortegano, Natalia Serrano, Carolina Ruiz, Mercedes Rodríguez, Carmen Prado, Mario Alía, Andrés Hidalgo, Eva Cano, Belén de Andrés, María-Luisa Gaspar   +9 more
doaj   +1 more source

Dual role of IL-21 in megakaryopoiesis and platelet homeostasis

Haematologica, 2017
Gene profiling studies have indicated that in vitro differentiated human megakaryocytes express the receptor for IL-21 (IL-21R), an immunostimulatory cytokine associated with inflammatory disorders and currently under evaluation in cancer therapy.
Salima Benbarche, Catherine Strassel, Catherine Angénieux, Léa Mallo, Monique Freund, Christian Gachet, François Lanza, Henri de la Salle   +7 more
doaj   +1 more source

CXCR4high megakaryocytes regulate host-defense immunity against bacterial pathogens

eLife, 2022
Megakaryocytes (MKs) continuously produce platelets to support hemostasis and form a niche for hematopoietic stem cell maintenance in the bone marrow.
Jin Wang, Jiayi Xie, Daosong Wang, Xue Han, Minqi Chen, Guojun Shi, Linjia Jiang, Meng Zhao   +7 more
doaj   +1 more source

Megakaryocyte- and megakaryocyte precursor–related gene therapies [PDF]

Blood, 2016
AbstractHematopoietic stem cells (HSCs) can be safely collected from the body, genetically modified, and re-infused into a patient with the goal to express the transgene product for an individual’s lifetime. Hematologic defects that can be corrected with an allogeneic bone marrow transplant can theoretically also be treated with gene replacement ...
openaire   +2 more sources