Results 41 to 50 of about 34,194 (287)

Megakaryocyte [PDF]

Einstein (São Paulo), 2011
Paulo Augusto Achucarro Silveira, Elvira Deolinda Rodrigues Pereira Velloso, Marjorie Paris Colombini, João Carlos de Campos Guerra, Nydia Strachman Bacal, Alanna Mara Pinheiro Sobreira Bezerra, Denise da Cunha Pasqualin   +6 more
  +9 more sources

SNARE-dependent glutamate release in megakaryocytes [PDF]

, 2010
ObjectiveThe identification of signaling pathways involved in megakaryocytopoiesis is essential for development of novel therapeutics to treat hematological disorders. Following our previous findings that megakaryocytes express functional channel-forming
Genever, Paul G., Howard, Martin R., Thompson, Catherine J., Schilling, Tatjana   +3 more
core   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Mechanisms of thrombocytopenia in platelet-type von Willebrand disease

Haematologica, 2019
Platelet-type von Willebrand disease is an inherited platelet disorder characterized by thrombocytopenia with large platelets caused by gain-of-function variants in GP1BA leading to enhanced GPIbα-von Willebrand factor (vWF) interaction.
Loredana Bury, Alessandro Malara, Stefania Momi, Eleonora Petito, Alessandra Balduini, Paolo Gresele   +5 more
doaj   +1 more source

Double-labelling immunohistochemical study of megakaryocytes in African swine fever

, 1997
Bone marrow samples from pigs infected with the highly virulent Malawi'83 or moderately virulent Dominican Republic (DR'78) isolates of African swine fever virus were studied by means of a double labelling immunohistochemical technique which stained the ...
Bautista, M. J., Sierra, M. A., Pérez, J., Rodríguez Guisado, Francisco, Wilkinson, P. J., Martín De Las Mulas, J.   +5 more
core   +1 more source

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

Modified application of Kawamoto’s film method for super‐resolution imaging of megakaryocytes in undecalcified bone marrow

Research and Practice in Thrombosis and Haemostasis, 2020
Background Super‐resolution microscopy has enabled high‐resolution imaging of the actin cytoskeleton in megakaryocytes and platelets. These technologies have extended our knowledge of thrombopoiesis and platelet spreading using megakaryocytes and ...
Yosuke Morodomi, Sachiko Kanaji, Eric Won, Tadafumi Kawamoto, Taisuke Kanaji   +4 more
doaj   +1 more source

Quantitative analysis of thrombopoietin receptors on human megakaryocytes [PDF]

, 1998
Thrombopoietin (TPO), or c-MPL ligand, is the primary regulator of megakaryocyte and platelet production. TPO receptors expressed on human megakaryocytes derived from peripheral blood (PB) and cord blood (CB) progenitors cultured in the presence of TPO ...
Tetsuya Hagiwara, Hagiwara, Tetsuya, Kodama, Ikuko, Yuki, Chizuru, Ikuko Kodama, Takashi Kato, Tomoaki Kuwaki, Kuwaki, Tomoaki, Kato, Takashi, Miyazaki, Hiroshi, Hiroshi Miyazaki, Chizuru Yuki   +11 more
core   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

Gfi1b controls integrin signaling-dependent cytoskeleton dynamics and organization in megakaryocytes

Haematologica, 2017
Mutations in GFI1B are associated with inherited bleeding disorders called GFI1B-related thrombocytopenias. We show here that mice with a megakaryocyte-specific Gfi1b deletion exhibit a macrothrombocytopenic phenotype along a megakaryocytic dysplasia ...
Hugues Beauchemin, Peiman Shooshtarizadeh, Charles Vadnais, Lothar Vassen, Yves D Pastore, Tarik Möröy   +5 more
doaj   +1 more source