Results 51 to 60 of about 34,194 (287)
Platelets, 2022 Janus kinase 2 (JAK2) gene mutations are the main drivers for polycythemia vera (PV) and essential thrombocythemia (ET). The mechanisms of single altered gene causing two different diseases are unclear.
Jaturawat Pawinwongchai +4 more
doaj +1 more source
Advanced Science, EarlyView.Single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq) integrates cell‐associated bacterial 16S‐derived signals with host transcriptomes to resolve bacterial signal‐enriched myeloid states in Klebsiella pneumoniae sepsis. Complementary pharmacological and genetic analyses define a CD38–NAD immunometabolic axis connecting mitochondrial bioenergetic ...
Yangguang Li +15 more
wiley +1 more source
Megakaryocytes in Bone Metastasis: Protection or Progression?
Cells, 2019 Bone is the primary site where some cancers develop secondary growth, particularly those derived from breast and prostate tissue. The spread of metastasis to distant sites relies on complex mechanisms by which only cells endowed with certain ...
Paola Maroni
doaj +1 more source
Studies on Megakaryocytes in the Spleen by Splenic Tissue Culture Method Part 3. Megakaryocytes in the Human Spleen [PDF]
, 1963 Followings are the results of studies by our clinical tissue culture method mainly on motility and ability of platelet formation of megakaryocytes in the spleen of human embryo and a patient with osteomyelofibrosis.
Hanzawa, Atsumasa
core
Concurrent Germline RB1 & Mosaic TP53 in a Child With Multiple Childhood Cancers
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT We report a patient with a pathogenic germline variant (PGV) in RB1 and somatic mosaicism for a pathogenic TP53 variant who developed three distinct types of childhood cancer: retinoblastoma, osteosarcoma, and myelodysplastic syndrome (MDS) before the age of 6 years.
Ole Haubjerg Nielsen +8 more
wiley +1 more source
Fibronectin Isoforms in Megakaryocytes [PDF]
Stem Cells, 1996 Our studies have shown that megakaryocytes (MK) can synthesize fibronectin (FN) and alternatively spliced fibronectin, FN EIIIB. FN EIIIB is primarily present in embryonic, proliferating and migrating cells, and thought to be important for cell maturation.
P K, Schick +3 more
openaire +2 more sources
Deletion of the podocalyxin gene in megakaryocytes.
, 2013 (A) PCR amplification of genomic DNA from either control or Podxl-null megakaryocytes. (B) In left panel, western blot of megakaryocyte lysates. In upper right panels, immunofluorescence of control and Podxl-null megakaryocytes labeled with anti-Podxl ...
Roberto Parrilla (20060) +7 more
core +1 more source
Umbilical Cord Blood Produces Small Megakaryocytes After Transplantation [PDF]
, 2007 Delayed platelet engraftment is a major complication of umbilical cord blood (CB) transplantation. Megakaryocytes derived from CB in vitro are smaller than megakaryocytes derived from bone marrow (BM) or mobilized peripheral blood from adults.
Li, Xiao-Miao +10 more
core +1 more source
Cytometry Part B: Clinical Cytometry, EarlyView.Abstract Acute myeloid leukemia (AML) is characterized by high genotypic and immunophenotypic heterogeneity. We collected an extensive dataset containing 5366 flow cytometry files from 885 AML patients, stained with the EuroFlow acute leukemia orientation tube (ALOT) and AML/MDS panel, acquired in a standardized way at eight centers over a period of 10
Sarah Bonte +13 more
wiley +1 more source
Erythroid and megakaryocytic transformation [PDF]
Oncogene, 2007 Red blood cells and megakaryocytes arise from a common precursor, the megakaryocyte-erythroid progenitor and share many regulators including the transcription factors GATA-1 and GFI-1B and signaling molecules such as JAK2 and STAT5. These lineages also share the distinction of being associated with rare, but aggressive malignancies that have very poor ...
A, Wickrema, J D, Crispino
openaire +2 more sources