Results 61 to 70 of about 34,194 (287)

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Dietary CoQ10 Ameliorates Age-Related Megakaryocyte Dysfunction via COPS3-Mediated Activation of Autophagy. [PDF]

Aging Cell
Dietary CoQ10 improves megakaryocyte maturation and polyploidization and reduces platelet hyperreactivity in naturally aged mice, while experiments in senescent Meg‐01 cells demonstrate enhanced autophagic flux and identify COPS3 as a contributing, but not, mediator.
Xu Y, Mao YH, Song F, He F, Wu Y, Wang C, Wang M, Xie S, Ni H, Yang Y.   +9 more
europepmc   +2 more sources

Reversal of Chronic Stress‐Induced Inflammaging by Bazi Bushen Formula Through AMPK‐Sirtuins Axis Activation and Myeloid Reset

Exploration, EarlyView.
Chronic stressors trigger systemic immune remodeling marked by myeloid expansion and lymphoid suppression, and this immune imbalance subsequently drives tissue pathology through proinflammatory signaling and senescence amplification, with the lung and kidney confirmed as the most vulnerable target organs.
Mengnan Li, Zheming Chen, Lu Wang, Zixuan Wang, Shixiong Zhang, Kunxu Niu, Xiaogang Shen, Xuan Lu, Runtao Zhang, Yuning Jiang, Yawen Li, Yi Dai, Xiyang Tang, Bin Hou, Min Shi, Xiaoya Wang, Zhifang Guo, Xingyu Xing, Ning Kang, Hongrong Li, Tianyu Kang, Evelyne Bischof, Yunlong Hou, Zhenhua Jia   +23 more
wiley   +1 more source

A megakaryocyte in the peripheral blood: evidence for pulmonary migration?

Frontiers in Hematology
Pulmonary megakaryocytes were first identified over a century ago, but their origin is still debated. Two rare images of circulating megakaryocytes are presented to illustrate this discussion: The first shows an intact megakaryocyte with abundant ...
Stephanie Juané Kennedy, Stephanie Juané Kennedy   +1 more
doaj   +1 more source

PLATELET TURNOVER AND ATHEROTHROMBOSIS

Атеротромбоз, 2017
Platelets play an important role in initiating atherothrombosis, i.e. the formation of blood clots inside a blood vessel at areas of atherosclerotic vascular injury.
A. V. MAZUROV
doaj   +1 more source

Engineered molecular diagnostic strategies for hepatocellular carcinoma: Integrating flexible photonic barcodes, liquid biopsies, and AI‐enhanced sensing platforms

FlexMat, EarlyView.
Abstract Early diagnosis of hepatocellular carcinoma (HCC) remains challenging because conventional serum biomarkers, especially alpha‐fetoprotein (AFP), show limited sensitivity for early‐stage disease. Recent progress in engineered molecular diagnostics provides new opportunities to improve HCC detection through integrated material, molecular, and ...
Jingzhi Xue, Wanqi Yang, Xiaoyu Liu, Xuehui Chu, Wei Li, Jinglin Wang   +5 more
wiley   +1 more source

MicroRNA function in megakaryocytes

Platelets, 2018
Megakaryocytes (MKs), the largest cells in the bone marrow, are generated from hematopoietic stem cells (HSCs) in a sequential process called megakaryocytopoiesis in which HSCs undergo MK-progenitor (MP) commitment and maturation to terminally differentiated MK.
Sanjeev Raghuwanshi, Swati Dahariya, Syed Shahid Musvi, Usha Gutti, Ravinder Kandi, Ram Babu Undi, Itishri Sahu, Dushyant Kumar Gautam, Indira Paddibhatla, Ravi Kumar Gutti   +9 more
openaire   +3 more sources

Methods for genetic modification of megakaryocytes and platelets.

, 2007
During recent decades there have been major advances in the fields of thrombosis and haemostasis, in part through development of powerful molecular and genetic technologies.
Spalton, Jennifer, Pendaries, C, Watson, Steve; id_orcid   +2 more
core   +1 more source

Monocyte inflammation and adaptive immune dysfunction in severe Klebsiella pneumoniae pneumonia

iMeta, EarlyView.
Severe Klebsiella pneumoniae pneumonia combines intense inflammation with failure to control infection, yet the cellular basis is unclear. Using a severity‐focused single‐cell atlas of 708,894 peripheral blood mononuclear cells from 100 individuals, complemented by plasma protein measurements and flow cytometry, we show that disease severity redirects ...
Hongquan Chen, Xiaoling Wang, Xiang Liu, Kui Dong, Yanying Feng, Min Yuan, Shiyi Wang, Fangfang Fan, Yong Tian, Zhiming Kang, Xiushuai Du, Chaolu Hasi, Hong Lu, Wei Guan, Xu Chen, Mengyu Cheng, Wei Wei, Nan Guo, Zhiguo Liu, Xiaotong Qiu, Yiwei Shi, Kun Xiao, Yi Wang, Zhenjun Li   +23 more
wiley   +1 more source

A subset of megakaryocytes regulates development of hematopoietic stem cell precursors

The EMBO Journal
Understanding the regulatory mechanisms facilitating hematopoietic stem cell (HSC) specification during embryogenesis is important for the generation of HSCs in vitro.
Wenlang Lan, Jinping Li, Zehua Ye, Yumin Liu, Sifan Luo, Xun Lu, Zhan Cao, Yifan Chen, Hongtian Chen, Zhuan Li   +9 more
doaj   +1 more source