Results 81 to 90 of about 34,194 (287)
PROTEOMICS, EarlyView.ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca +7 more
wiley +1 more source
Asian Journal of Transfusion Science, 2015 Background: Thrombopoietin (TPO) is the key hematopoietic growth factor regulating the production of platelets from bone marrow megakaryocytes and maintaining platelet hemostasis.
Abhay Singh +4 more
doaj +1 more source
Cell‐Based Micro/Nanorobots: From Living Carriers to Living Therapeutic Specialists
SmartBot, EarlyView.Cell‐based micro/nanorobots integrate evolutionarily acquired biological intelligence with engineered capabilities, offering new opportunities for precision medicine in vivo. However, the complex physiological environments of different organs pose significant challenges to their clinical translation.
Junfeng Wu +12 more
wiley +1 more source
Do Megakaryocytes Regulate Mechanical Loading Induced Bone Formation? [PDF]
Background and Hypothesis: Megakaryocytes are known to play a role in stimulating bone formation and recent studies from our laboratory show higher numbers of megakaryocytes in mice subjected to mechanical loading.
Maupin, Kevin A. +6 more
core +1 more source
Veterinary Record, EarlyView.Abstract Background Hepatocellular carcinoma (HCC) is the most common canine hepatobiliary tumour. This study aimed to determine which criteria influenced outcome of HCC in a modern population of dogs across eight institutions. Methods The medical records of 106 dogs with HCC were retrospectively reviewed.
Emily A. Janik +2 more
wiley +1 more source
From haemostasis to immunity: The expanding frontiers of platelet biology
British Journal of Haematology, EarlyView.Platelets are versatile cells whose functions extend far beyond haemostasis and thrombosis, actively regulating innate and adaptive immunity, angiogenesis, lymphangiogenesis, liver regeneration, atherosclerosis and tumour metastasis. This demonstrates their central role in various physiological processes and multiple life‐threatening diseases ...
Xun Grace Wu, Nicole Tomei, Heyu Ni
wiley +1 more source
Histology and histopathology, 1999 We reviewed the literature concerning the history of determination of the ploidy of human megakaryocytes and its relationship with diseases. The ploidy of rabbit megakaryocytes was analyzed by microspectrophotometry in 1964, and the analysis of the ploidy in human megakaryocytes was first performed in 1968. Presently, microphotometry and flow cytometry
Kobayashi, Y., Kondo, M.
openaire +3 more sources
Studies on Megakaryocytes in the Spleen by Splenic Tissue Culture Method Part 1. Megakaryocytes in the Spleen of the Rodent (Mice, Rats, Guinea Pigs, and Rabbits) [PDF]
, 1963 Followings are the results of studies on megakaryocytes in the spleen of the rodent of the successive stages from the embryonic stage up to the adult.
Hanzawa, Atsumasa
core
Increased active Rap1 in Rasa3−/− megakaryocytes.
, 2014 Fetal liver cells (FLC) were isolated from E12.5 Rasa3+/+ and Rasa3−/− embryos and cultured with TPO. A. Non adherent megakaryocytes on day 6 were analyzed for active, GTP-bound Rap1 by immunofluorescence using GST-RalGDS-RBD and a FITC-conjugated mAb ...
Patricia Molina-Ortiz (167505) +7 more
core +1 more source
British Journal of Haematology, EarlyView.Elevated percentage of immature platelets is indicative of consumptive thrombocytopenic disorders. In immune thrombocytopenia, low platelet counts may result from reduced production or increased degradation, both driven by IgG autoantibodies. By blocking FcRn, efgartigimod decreases immature platelet fraction, likely by reducing platelet degradation ...
Hanny Al‐Samkari +9 more
wiley +1 more source