Results 101 to 110 of about 34,194 (287)
Role of p21Cip1/Waf1 in cell-cycle exit of endomitotic megakaryocytes
, 2001 International audienceAbstract The cyclin-dependent kinase inhibitor p21Waf-1/Cip-1 is expressed at high level during megakaryocyte differentiation, but its precise function remains unknown. In this study, it is confirmed that p21 was expressed at a high
Chagraoui, Hédia +8 more
core +1 more source
Cell Proliferation, EarlyView.The use of FG‐4592 in the process of myeloablation can promote haematopoietic cell apoptosis for more effective myeloablation, maintain the number of RBC and may create a pluripotent microenvironment suitable for donor cells, so as to enable more effective haematopoietic reconstruction of donor cells in vivo.
Guanheng Yang +8 more
wiley +1 more source
Arteriosclerosis, Thrombosis, and Vascular Biology, 2020 Philip J. Crispin, Samantha J. Montague
openaire +2 more sources
Effects of Estrogens on Platelets and Megakaryocytes
, 2019 International audienceIn women, oral menopausal hormonal therapy (MHT) is associated with adverse effects including an increased incidence of thromboembolic events, classically attributed to an increase in several liver-derived coagulation factors due to
Severin, Sonia +5 more
core +1 more source
Ploidy‐Dependent Response to Anticancer Drugs of Human Embryonic Stem Cells
Cell Proliferation, EarlyView.Using isogenic hESCs, differing only in their ploidy level, we show the effect of ploidy on the resistance to anticancer drugs. We demonstrate that polyploidy, by itself, confers sensitivity to chemotherapies, leading to higher apoptosis and delayed proliferation, while the loss of p53 reverses the phenotype, demonstrating higher resistance.
Guy Haim‐Abadi, Nissim Benvenisty
wiley +1 more source
Megakaryocytes and Platelets in Immune and Inflammatory Responses and in COVID-19
, 2020 Platelets-small cells which circulate in abundance in the bloodstream-are traditionally known for their ability to form clots and stop bleeding. Recent studies, however, have shown that platelets and their parent cells, megakaryocytes, also play a role ...
Campbell, R.; Rondina, M.; Schwertz, H.; Rowley, J.; Bray, P.; Zimmerman, G.; Weyrich, A.; Middleton, E.; Petrey, A.; Yost, C.C.
core
Dengue viruses infect human megakaryocytes, with probable clinical consequences
, 2019 One of the most important clinical signs of dengue virus infection is the reduction of white blood cells and platelets in human peripheral blood (leukopenia and thrombocytopenia, respectively), which may significantly impair the clearance of dengue virus
Megan B Vogt +9 more
core +1 more source
European Journal of Haematology, EarlyView.ABSTRACT Despite disseminated intravascular coagulation (DIC) and thrombotic microangiopathy (TMA) sharing features of thrombocytopenia, organ dysfunction, and bleeding, the relationship between these two conditions remains unclear. We therefore conducted a post hoc analysis of post‐marketing surveillance data from Japan to evaluate the clinical ...
Naoki Takezako +11 more
wiley +1 more source
, 1997 Our goals have been to define the biochemical characteristics of megakaryocytes during maturation that are critical for platelet assembly and release into the circulation and to introduce biochemical markers for megakaryocytes. To achieve these goals, we
Paul K. Schick +4 more
core +1 more source
European Journal of Haematology, EarlyView.ABSTRACT Eosinophilia, defined as an absolute eosinophil count (AEC) of ≥ 0.5 × 109/L, is a frequently encountered finding with a vast spectrum of potential underlying etiologies. Hypereosinophilia (HE) is defined as AEC > 1.5 × 109/L and may become life‐threatening when eosinophil‐induced organ damage occurs, defining the hypereosinophilic syndrome ...
Stijn Wigerinck, Peter Vandenberghe
wiley +1 more source