Results 111 to 120 of about 34,194 (287)

Tetraspanin CD9 participates in dysmegakaryopoiesis and stromal interactions in primary myelofibrosis

Haematologica, 2015
Primary myelofibrosis is characterized by clonal myeloproliferation, dysmegakaryopoiesis, extramedullary hematopoiesis associated with myelofibrosis and altered stroma in the bone marrow and spleen.
Christophe Desterke, Christophe Martinaud, Bernadette Guerton, Lisa Pieri, Costanza Bogani, Denis Clay, Frederic Torossian, Jean-Jacques Lataillade, Hans C. Hasselbach, Heinz Gisslinger, Jean-Loup Demory, Brigitte Dupriez, Claude Boucheix, Eric Rubinstein, Sophie Amsellem, Alessandro M. Vannucchi, Marie-Caroline Le Bousse-Kerdilès   +16 more
doaj   +1 more source

Genetic studies of hereditary thrombocythemia [PDF]

, 2013
Hereditary thrombocythemia (HT) is a familial myeloproliferative disorder characterized by an elevated platelet count in peripheral blood. Thrombocytosis is due to a genetic alteration that can be transmitted to the offspring.
Pianta, Annalisa
core   +1 more source

Bone Marrow Fibrosis as a Predictor of Extramedullary Disease in Multiple Myeloma

European Journal of Haematology, EarlyView.
ABSTRACT The correlation between bone marrow fibrosis (BMF) and extramedullary disease has yet to be fully elucidated in patients with newly diagnosed multiple myeloma. Therefore, we aimed to analyze the incidence of BMF in newly diagnosed multiple myeloma patients and evaluate the relationship between BMF and synchronous soft tissue extramedullary ...
Hilal Senkal, Ali Yilmaz Altay, Emine Goknur Isik, Simge Erdem, Metban Mastanzade, Gulcin Yegen, Mustafa Murat Ozbalak, İpek Yonal Hindilerden, Mustafa Nuri Yenerel, Sevgi Kalayoglu Besisik   +9 more
wiley   +1 more source

Overexpression of cyclin D1 moderately increases ploidy in megakaryocytes

Haematologica, 2001
BACKGROUND AND OBJECTIVES: Megakaryocytes undergo a unique cell cycle by which they replicate their complete genome many times in the absence of cytokinesis.
S Sun, JM Zimmet, P Toselli, A Thompson, CW Jackson, K Ravid   +5 more
doaj  

How I Investigate Bleeding Disorders of Unknown Cause: Current Diagnostic Pathways and Gaps in Laboratory Investigation

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Bleeding disorder of unknown cause (BDUC) constitutes the largest group of patients presenting with a mild‐to‐moderate bleeding tendency in tertiary care settings. Their clinical bleeding phenotype is characterized by mucocutaneous bleeding, as well as bleeding following surgical challenges or childbirth, and is associated with impaired health‐
Dino Mehic, Faris Karaselimovic, Tim Dreier, Johanna Gebhart   +3 more
wiley   +1 more source

Engineered and hybrid human megakaryocytic extracellular vesicles for targeted non-viral cargo delivery to hematopoietic (blood) stem and progenitor cells

Frontiers in Bioengineering and Biotechnology
Native and engineered extracellular vesicles generated from human megakaryocytes (huMkEVs) or from the human megakaryocytic cell line CHRF (CHEVs) interact with tropism delivering their cargo to both human and murine hematopoietic stem and progenitor ...
Samik Das, Samik Das, Will Thompson, Will Thompson, Eleftherios Terry Papoutsakis, Eleftherios Terry Papoutsakis, Eleftherios Terry Papoutsakis   +6 more
doaj   +1 more source

Testing for Non‐Severe Heritable Platelet Function Disorders

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Heritable platelet function disorders (HPFD) are a diverse group of bleeding disorders characterised by a primary qualitative defect in platelet function rather than platelet number. HPFD may be broadly categorised according to the severity of bleeding, with Glanzmann thrombasthenia and Bernard Soulier syndrome classically considered severe ...
Kate Burley, Naomi Cornish, Maria Molina Carretero, Sarah K. Westbury   +3 more
wiley   +1 more source

Platelet life cycle during aging: function, production and clearance

Platelets
Platelets are important players in hemostasis. Alterations in platelet number and/or function lead to life-threatening conditions like thrombosis, myocardial infarction and stroke.
Friedrich Reusswig, Olga An, Carsten Deppermann   +2 more
doaj   +1 more source

Mother Cell of Megakaryocyte

The Tohoku Journal of Experimental Medicine, 1975
It was attempted to describe the morphology of the most immature cell of megakaryocytic series. The megakaryocytes were observed with the electron microscope in five cases, being traced back to their immature forms. In two cases the most immature cells of megakaryocytic series were considered to be the cells which were probably identified as ...
openaire   +3 more sources

Megakaryocytes in agar cultures of mouse bone marrow

, 1975
Cytologic and immunofluorescent data demonstrate that cells morphologically resembling megakaryocytes appear in thin layer agar cultures of cellular fractions of mouse bone marrow and increase in number from zero to a maximum of approxiamately 60 per ...
Nakeff, A., Dicke, K.A., Noord M.J. van
core