Results 91 to 100 of about 34,194 (287)

Acute Megakaryocytic Leukemia

Cold Spring Harbor Perspectives in Medicine, 2019
Acute megakaryoblastic leukemia (AMKL) is a rare malignancy affecting megakaryocytes, platelet-producing cells that reside in the bone marrow. Children with Down syndrome (DS) are particularly prone to developing the disease and have a different age of onset, distinct genetic mutations, and better prognosis as compared with individuals without DS who ...
Maureen, McNulty, John D, Crispino
openaire   +3 more sources

Increased anergic B cells and decreased antibody‐secreting cells during romiplostim treatment in patients with immune thrombocytopenia

British Journal of Haematology, EarlyView.
Summary Patients with immune thrombocytopenia (ITP) exhibit substantial heterogeneity in treatment responses. Approximately 30%–50% of patients maintain remission after discontinuation of thrombopoietin receptor agonists (TPO‐RA), suggesting immunomodulatory effects beyond enhanced thrombopoiesis.
Vivianne S. Nelson, Rebeca Gutiérrez‐Cózar, Rebecca Cornelis, S. Marieke van Ham, Anja ten Brinke, Rick Kapur   +5 more
wiley   +1 more source

Dengue virus modulates critical cell cycle regulatory proteins in human megakaryocyte cells

Scientific Reports
Suppression of human megakaryocytes by dengue virus (DENV) infection significantly reduces the platelet count that eventually leads to thrombocytopenia, severe dengue and death.
Swarnendu Basak, Shovan Dutta, Supreet Khanal, Girish Neelakanta, Hameeda Sultana   +4 more
doaj   +1 more source

Gliomas with pleomorphic and pseudopapillary features (GPAP) are circumscribed tumors with targetable mutations, prolonged survival, and frequent tumor predisposition

Brain Pathology, EarlyView.
DNA methylation profiling identifies GPAP as a distinct circumscribed glioma with a characteristic expansive, multicystic radiological appearance, pleomorphic and pseudopapillary histology, a recognizable CNV profile, druggable molecular alterations, and recurrent cancer predisposition syndromes.
Alberto Picca, Valeria Barresi, Aude Trinquet, Luca Bertero, Lucia Nichelli, Guillaume Chotard, Michèle Bernier, Thomas Gareau, Salah Eddine Oussama Kacimi, Jaydutt Bhalshankar, Mathilde Filser, Julien Masliah‐Planchon, Marta Iollo, Henri Malaize, Bertrand Mathon, Luc Bauchet, Kifah Khouri, Besma Barka, Hélène Madry, Sabrina Rossi, Evelina Miele, Giuseppe Kenneth Ricciardi, Catherine Carpentier, Irina Coin, Marc Sanson, Mehdi Touat, Caroline Dehais, Alessia Pellerino, Roberta Rudà, Paola Cassoni, Valérie Rigau, Emmanuelle Uro‐Coste, Karima Mokhtari, Ahmed Idbaih, Patrick R. Benusiglio, Franck Bielle   +35 more
wiley   +1 more source

Pediatric Essential Thrombocythemia With a Novel <i>CALR</i> Mutation: A Case Report. [PDF]

EJHaem
ABSTRACT Pediatric essential thrombocythemia (ET) is extremely rare and frequently lacks identifiable driver mutations. We report a case of a 5‐year‐old male with ET harboring a novel CALR exon 9 frameshift mutation complicated by acquired von Willebrand syndrome.
Tsuji K, Uemura S, Fujikawa T, Yamamoto N, Kozaki A, Saito A, Ishida T, Mori T, Yoshida M, Okutani T, Hasegawa D.   +10 more
europepmc   +2 more sources

Abnormal proplatelet formation and emperipolesis in cultured human megakaryocytes from gray platelet syndrome patients [PDF]

, 2016
The Gray Platelet Syndrome (GPS) is a rare inherited bleeding disorder characterized by deficiency of platelet α-granules, macrothrombocytopenia and marrow fibrosis.
Glembotsky, Ana Claudia, Di Buduo, Christian A., Cattaneo, Marco, Heller, Paula G., Alberelli, Maria Adele, Lev, Paola R., Lev, Paola Roxana, Podda, Gianmarco, De Candia, Erica, Landolfi, Raffaele, Heller, Paula Graciela, Balduini, Alessandra, DI BUDUO, CHRISTIAN ANDREA, Glembostky, Ana C.   +13 more
core   +1 more source

Machine Learning‐Derived Immune Gene Signature Predicts Prognosis and Therapeutic Vulnerabilities in Multiple Myeloma

Cancer Science, EarlyView.
An immune‐related 12‐gene signature developed through integrative machine learning stratified overall survival across multiple myeloma cohorts and remained independently associated with outcome. Single‐cell, somatic mutation, and transcriptome‐based drug‐response analyses further linked the signature to multicellular bone marrow context, distinct ...
Kai Wang, Chenfei Zhao, Jingru Shi, Shiwei Liu, Yi Chen, Jujuan Wang, Zhengxu Sun, Sanmei Wang, Lei Fan, Jin Fan, Xiaoyan Qu   +10 more
wiley   +1 more source

A novel method for automated assessment of megakaryocyte differentiation and proplatelet formation

Platelets, 2018
Transfusion of platelet concentrates represents an important treatment for various bleeding complications. However, the short half-life and frequent contaminations with bacteria restrict the availability of platelet concentrates and raise a clear demand ...
M. Salzmann, B. Hoesel, M. Haase, M. Mussbacher, WC. Schrottmaier, JB. Kral-Pointner, M. Finsterbusch, A. Mazharian, A. Assinger, JA. Schmid   +9 more
doaj   +1 more source

Separation of megakaryocytes from mouse bone marrow by velocity sedimentation

, 1974
A technique for separating mouse bone marrow megakaryocytes by unit gravity velocity sedimentation is described using a modified sedimentation chamber.
Maat, B., Nakeff, A.
core  

Research progress of megakaryocytes and platelets in lung injury

The lung is an important site of extramedullary platelet formation, and megakaryocytes in the lung participate in immune responses in addition to platelet production.
Yi Yao, Haoran Jia, Guangliang Zhang, Tianzhen Hua, Wei Liu   +4 more
core   +1 more source