Results 31 to 40 of about 34,194 (287)
The CXCR1/CXCR2 Inhibitor Reparixin Alters the Development of Myelofibrosis in the Gata1low Mice
Frontiers in Oncology, 2022 A major role for human (h)CXCL8 (interleukin-8) in the pathobiology of myelofibrosis (MF) has been suggested by observations indicating that MF megakaryocytes express increased levels of hCXCL8 and that plasma levels of this cytokine in MF patients are ...
Paola Verachi +17 more
doaj +1 more source
Platelets, Not an Insignificant Player in Development of Allergic Asthma
Cells, 2021 Allergic asthma is a chronic and heterogeneous pulmonary disease in which platelets can be activated in an IgE-mediated pathway and migrate to the airways via CCR3-dependent mechanism.
Liping Luo +3 more
doaj +1 more source
Salicylate Inhibits Thrombopoiesis in Rat Megakaryocytes by Changing the Membrane Micro-Architecture
Cellular Physiology and Biochemistry, 2015 Background/Aims: Salicylate causes drug-induced immune thrombocytopenia. However, some clinical studies indicate the presence of additional mechanisms in the drug-induced thrombocytopenia, by which the platelet production from megakaryocytes may directly
Itsuro Kazama +6 more
doaj +1 more source
, 2010 An image from a bone marrow direct smear under 10X magnification showing multiple megakaryocytes in the tail of the ...
Fraser, Marion
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh +4 more
wiley +1 more source
, 2010 An image from a bone marrow direct smear under 20X magnification showing a cluster of megakaryocytes in the tail of the ...
Fraser, Marion
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Anti-apoptotic BCL2L2 increases megakaryocyte proplatelet formation in cultures of human cord blood
Haematologica, 2019 Apoptosis is a recognized limitation to generating large numbers of megakaryocytes in culture. The genes responsible have been rigorously studied in vivo in mice, but are poorly characterized in human culture systems.
Seema Bhatlekar +10 more
doaj +1 more source
Large RhoA-null megakaryocytes are less compliant than normal sized megakaryocytes.
, 2013 (A) Pictured are representative cells being aspirated with micropipettes (ΔP 0.3–5.7 kPa) causing the cell membrane protrusion (arrows) to extend in length over time.
Yangfeng Wang (436175) +11 more
core +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source