Results 21 to 30 of about 27,974 (255)

Changes in Megakaryocytes in Cases of Thrombocytopenia: Bone Marrow Aspiration and Biopsy Analysis [PDF]

Journal of Clinical and Diagnostic Research, 2013
Background: Thrombocytopenia (platelet counts less than 150,000/μl) is commonly encountered in various hematological disorders including myelodysplastic syndromes as well as various non-myelodysplastic hematological conditions.
Tejinder Singh Bhasin, Sonam Sharma, Mridu Manjari, Rahul Mannan, Vandana Kansal, Manish Chandey, Sanjay Piplani   +6 more
doaj   +1 more source

CD226 Is Required to Maintain Megakaryocytes/Platelets Homeostasis in the Treatment of Knee Osteoarthritis With Platelet-Rich Plasma in Mice

Frontiers in Pharmacology, 2021
Platelet-rich plasma (PRP) is a platelet-based application used to treat osteoarthritis (OA) clinically. The co-stimulatory molecule CD226 is expressed in T cells, NK cells, and also platelets. However, exact effects of CD226 on platelets and whether its
Yongming Liu, Yuan Zhang, Jinxue Zhang, Jingchang Ma, Ka Bian, Yuling Wang, Xuexue Xu, Shuwen Wu, Kun Cheng, Yun Zhang, Yong Ding, Yong Zhou, Ran Zhuang, Ran Zhuang   +13 more
doaj   +1 more source

Osteomacs interact with megakaryocytes and osteoblasts to regulate murine hematopoietic stem cell function

Blood Advances, 2017
: Networking between hematopoietic stem cells (HSCs) and cells of the hematopoietic niche is critical for stem cell function and maintenance of the stem cell pool.
Safa F. Mohamad, Linlin Xu, Joydeep Ghosh, Paul J. Childress, Irushi Abeysekera, Evan R. Himes, Hao Wu, Marta B. Alvarez, Korbin M. Davis, Alexandra Aguilar-Perez, Jung Min Hong, Angela Bruzzaniti, Melissa A. Kacena, Edward F. Srour   +13 more
doaj   +1 more source

The CXCR1/CXCR2 Inhibitor Reparixin Alters the Development of Myelofibrosis in the Gata1low Mice

Frontiers in Oncology, 2022
A major role for human (h)CXCL8 (interleukin-8) in the pathobiology of myelofibrosis (MF) has been suggested by observations indicating that MF megakaryocytes express increased levels of hCXCL8 and that plasma levels of this cytokine in MF patients are ...
Paola Verachi, Francesca Gobbo, Francesca Gobbo, Fabrizio Martelli, Andrea Martinelli, Giuseppe Sarli, Andrew Dunbar, Andrew Dunbar, Ross L. Levine, Ross L. Levine, Ross L. Levine, Ronald Hoffman, Maria Teresa Massucci, Laura Brandolini, Cristina Giorgio, Marcello Allegretti, Anna Rita Migliaccio, Anna Rita Migliaccio   +17 more
doaj   +1 more source

Platelets, Not an Insignificant Player in Development of Allergic Asthma

Cells, 2021
Allergic asthma is a chronic and heterogeneous pulmonary disease in which platelets can be activated in an IgE-mediated pathway and migrate to the airways via CCR3-dependent mechanism.
Liping Luo, Junyan Zhang, Jongdae Lee, Ailin Tao   +3 more
doaj   +1 more source

Salicylate Inhibits Thrombopoiesis in Rat Megakaryocytes by Changing the Membrane Micro-Architecture

Cellular Physiology and Biochemistry, 2015
Background/Aims: Salicylate causes drug-induced immune thrombocytopenia. However, some clinical studies indicate the presence of additional mechanisms in the drug-induced thrombocytopenia, by which the platelet production from megakaryocytes may directly
Itsuro Kazama, Asuka Baba, Yasuhiro Endo, Hiroaki Toyama, Yutaka Ejima, Mitsunobu Matsubara, Masahiro Tachi   +6 more
doaj   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Synthesis of Cyclopropene‐Modified Fatty Acids Allows Single‐Cell Quantification of Uptake by Immune Cells

Angewandte Chemie, EarlyView.
Cyclopropene fatty acids have been made that allow the study of fatty acid uptake in complex mixtures of immune cells with single cell resolution and combined with metabolic and proteomic analysis so that for the first time nutrient uptake can be correlated to the phenotype of single immune cell.
Luuk Reinalda, Graham A. Heieis, Laura Bogue Edgerton, Kristine Bertheussen, Diana Torres‐García, Marouane el Boujadayni, Kas Steuten, Jeroen M. Punt, Wouter P. F. Driever, Connor Corrigan, Xinyuan Wang, Bart Everts, David Finlay, Mario van der Stelt, Sander I. van Kasteren   +14 more
wiley   +2 more sources

Anti-apoptotic BCL2L2 increases megakaryocyte proplatelet formation in cultures of human cord blood

Haematologica, 2019
Apoptosis is a recognized limitation to generating large numbers of megakaryocytes in culture. The genes responsible have been rigorously studied in vivo in mice, but are poorly characterized in human culture systems.
Seema Bhatlekar, Indranil Basak, Leonard C. Edelstein, Robert A. Campbell, Cory R. Lindsey, Joseph E. Italiano, Andrew S. Weyrich, Jesse W. Rowley, Matthew T. Rondina, Martha Sola-Visner, Paul F. Bray   +10 more
doaj   +1 more source