Results 21 to 30 of about 34,194 (287)

Culture of Megakaryocytes from Human Peripheral Blood Mononuclear Cells

Bio-Protocol, 2015
Megakaryocytes are the precursor cells of platelets and are bona fide resident cells in the bone marrow but extremely low in numbers (~1% of total nucleated cells).
Vishal Salunkhe, Petros Papadopoulos, Laura Gutiérrez   +2 more
doaj   +1 more source

Emperipolesis: Sternal and femoral microenvironment induces megakaryiocyte emperipolesis in the Wistar strain

Macedonian Veterinary Review, 2019
Emperipolesis is considered a physiological phenomena often present in various pathophysiological conditions, but its etiology is still unknown. In this study, we analyzed the number of megakaryocytes and the percentage of emperipoletic cells in the ...
Damir Suljević, Filip Filipić, Erna Islamagić   +2 more
doaj   +1 more source

CXCR4high megakaryocytes regulate host-defense immunity against bacterial pathogens

eLife, 2022
Megakaryocytes (MKs) continuously produce platelets to support hemostasis and form a niche for hematopoietic stem cell maintenance in the bone marrow.
Jin Wang, Jiayi Xie, Daosong Wang, Xue Han, Minqi Chen, Guojun Shi, Linjia Jiang, Meng Zhao   +7 more
doaj   +1 more source

Brain-derived neurotrophic factor in megakaryocytes [PDF]

, 2016
The biosynthesis of endogenous BDNF has thus far been examined in neurons where it is expressed at very low levels, in an activity-dependent fashion. In humans, BDNF has long been known to accumulate in circulating platelets, at levels far higher than in
Sauberli, Katharina, Barde, Yves-Alain, Moreau, Thomas, Colzani, Maria, Ghevaert, Cedric, Chacon-Fernandez, Pedro   +5 more
core   +1 more source

Dual role of IL-21 in megakaryopoiesis and platelet homeostasis

Haematologica, 2017
Gene profiling studies have indicated that in vitro differentiated human megakaryocytes express the receptor for IL-21 (IL-21R), an immunostimulatory cytokine associated with inflammatory disorders and currently under evaluation in cancer therapy.
Salima Benbarche, Catherine Strassel, Catherine Angénieux, Léa Mallo, Monique Freund, Christian Gachet, François Lanza, Henri de la Salle   +7 more
doaj   +1 more source

Changes in Megakaryocytes in Cases of Thrombocytopenia: Bone Marrow Aspiration and Biopsy Analysis [PDF]

Journal of Clinical and Diagnostic Research, 2013
Background: Thrombocytopenia (platelet counts less than 150,000/μl) is commonly encountered in various hematological disorders including myelodysplastic syndromes as well as various non-myelodysplastic hematological conditions.
Tejinder Singh Bhasin, Sonam Sharma, Mridu Manjari, Rahul Mannan, Vandana Kansal, Manish Chandey, Sanjay Piplani   +6 more
doaj   +1 more source

Megakaryocytes morphology in idiopathic (primary) myelofibrosis [PDF]

, 2004
SummaryBackgroundThe cause of idiopathic myelofibrosis (IM) originating from a haemopoietic stem cells with development of secondary marrow fibrosis is unknown.
Dyagil, Iryna S., Byelinska, Iryna V., Iryna N. Kabachenko, Kabachenko, Iryna N., Iryna S. Dyagil, Iryna V. Byelinska   +5 more
core   +1 more source

Osteomacs interact with megakaryocytes and osteoblasts to regulate murine hematopoietic stem cell function

Blood Advances, 2017
: Networking between hematopoietic stem cells (HSCs) and cells of the hematopoietic niche is critical for stem cell function and maintenance of the stem cell pool.
Safa F. Mohamad, Linlin Xu, Joydeep Ghosh, Paul J. Childress, Irushi Abeysekera, Evan R. Himes, Hao Wu, Marta B. Alvarez, Korbin M. Davis, Alexandra Aguilar-Perez, Jung Min Hong, Angela Bruzzaniti, Melissa A. Kacena, Edward F. Srour   +13 more
doaj   +1 more source

CD226 Is Required to Maintain Megakaryocytes/Platelets Homeostasis in the Treatment of Knee Osteoarthritis With Platelet-Rich Plasma in Mice

Frontiers in Pharmacology, 2021
Platelet-rich plasma (PRP) is a platelet-based application used to treat osteoarthritis (OA) clinically. The co-stimulatory molecule CD226 is expressed in T cells, NK cells, and also platelets. However, exact effects of CD226 on platelets and whether its
Yongming Liu, Yuan Zhang, Jinxue Zhang, Jingchang Ma, Ka Bian, Yuling Wang, Xuexue Xu, Shuwen Wu, Kun Cheng, Yun Zhang, Yong Ding, Yong Zhou, Ran Zhuang, Ran Zhuang   +13 more
doaj   +1 more source

Megakaryocyte- and megakaryocyte precursor–related gene therapies [PDF]

Blood, 2016
AbstractHematopoietic stem cells (HSCs) can be safely collected from the body, genetically modified, and re-infused into a patient with the goal to express the transgene product for an individual’s lifetime. Hematologic defects that can be corrected with an allogeneic bone marrow transplant can theoretically also be treated with gene replacement ...
openaire   +2 more sources