Results 81 to 90 of about 8,227 (218)

Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p

Nature Communications, 2020
Platelets derive from megakaryocytes, which differentiate from hematopoietic stem/progenitor cells (HSPCs). Here, Qu et al show that platelet-derived microparticles carrying miR-1915-3p target HSPCs and promote megakaryopoiesis by suppressing RHOB ...
Mingyi Qu, Xiaojing Zou, Fang Fang, Shouye Wang, Lei Xu, Quan Zeng, Zeng Fan, Lin Chen, Wen Yue, Xiaoyan Xie, Xuetao Pei   +10 more
doaj   +1 more source

Biocatalytic Nanoregulators Restore Joint Redox‐Immune Homeostasis in Rheumatoid Arthritis

Advanced Science, Volume 13, Issue 10, 18 February 2026.
Mesenchymal stem cell‐derived extracellular vesicles (EVs) coat ruthenium‐loaded metal‐organic frameworks (Ru@ZrMOF), creating a targeted therapeutic (Ru@ZrMOF/EVs). This platform scavenges ROS, generates oxygen, and polarizes macrophages from M1 to M2, alleviating inflammation, inhibiting pannus, promoting cartilage repair, and downregulating HIF‐1α ...
Xingheng Wang, Jianbo Huang, Shuwei Zhang, Sujiao Cao, Fangxue Du, Liqiang Zhou, Li Qiu, Yuanjiao Tang   +7 more
wiley   +1 more source

The incredible journey: From megakaryocyte development to platelet formation [PDF]

, 2014
Circulating blood platelets are specialized cells that prevent bleeding and minimize blood vessel injury. Large progenitor cells in the bone marrow called megakaryocytes (MKs) are the source of platelets.
Italiano, Joseph E., Machlus, Kellie R.
core   +1 more source

Establishment of an ES cell-derived murine megakaryocytic cell line, MKD1, with features of primary megakaryocyte progenitors.

PLoS ONE, 2012
Because of the scarcity of megakaryocytes in hematopoietic tissues, studying megakaryopoiesis heavily relies on the availability of appropriate cellular models.
Hedia Chagraoui, Catherine Porcher
doaj   +1 more source

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

miR-494-3p overexpression promotes megakaryocytopoiesis in primary myelofibrosis hematopoietic stem/progenitor cells by targeting SOCS6 [PDF]

, 2017
Primary myelofibrosis (PMF) is a chronic Philadelphia-negative myeloproliferative neoplasm characterized by hematopoietic stem cell-derived clonal myeloproliferation, involving especially the megakaryocyte lineage.
Barosi, Giovanni, Bianchi, Elisa, Guglielmelli, Paola, Manfredini, Rossella, Norfo, Ruggiero, Pennucci, Valentina, Prudente, Zelia, Rontauroli, Sebastiano, Rossi, Chiara, Rosti, Vittorio, Ruberti, Samantha, Salati, Simona, Tagliafico, Enrico, Vannucchi, Alessandro, Zini, Roberta   +14 more
core   +1 more source

CSF1R modulates megakaryopoiesis by targeting RUNX1 in immune thrombocytopenia

Haematologica
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by platelet destruction and defective megakaryopoiesis. However, the mechanisms underlying megakaryocyte (MK) dysfunction in ITP remain unclear. To address this, we performed
Haohao Han, Meng Zhou, Jiaqian Qi, Xiaofei Song, Xueqian Li, Ziyan Zhang, Tingting Pan, Xiaoyan Xu, Mengting Guo, Depei Wu, Yue Han   +10 more
doaj   +1 more source

2-O, 3-O desulfated heparin mitigates murine chemotherapy- and radiation-induced thrombocytopenia

Blood Advances, 2018
: Thrombocytopenia is a significant complication of chemotherapy and radiation therapy. Platelet factor 4 (PF4; CXCL4) is a negative paracrine of megakaryopoiesis.
Elizabeth Tkaczynski, Abinaya Arulselvan, John Tkaczynski, Stephen Avery, Liqing Xiao, Beverly Torok-Storb, Kraig Abrams, Narayanam V. Rao, Gregory Johnson, Thomas P. Kennedy, Mortimer Poncz, Michele P. Lambert   +11 more
doaj   +1 more source

Aging of the Hematopoietic System: Mechanisms, Consequences, and Systemic Interactions

Aging Cell, Volume 25, Issue 2, February 2026.
Hematopoietic aging arises from intrinsic stem‐cell decline and bone‐marrow niche dysfunction, leading to myeloid skewing, immunosenescence, and clonal hematopoiesis. These changes drive systemic inflammation and multi‐organ disease, which in turn further disrupt the bone‐marrow niche and hematopoietic stem cell (HSC) function, creating a vicious cycle
Masashi Miyawaki, Seiji Hashimoto, Sumito Ogawa, Yoshitaka Kase   +3 more
wiley   +1 more source

Regulation of differentiation of MEG01 to megakaryocytes and platelet-like particles by Valproic acid through Notch3 mediated actin polymerization

Platelets, 2019
Valproic acid (VPA) is one of the HDAC inhibitors used for the treatment of neurological disorders and hematological malignancies. Its role in self-renewal and proliferation of hematopoietic stem cells (HSCs) is well studied, but little is known about ...
Ankita Dhenge, Rutuja Kuhikar, Vaijayanti Kale, Lalita Limaye   +3 more
doaj   +1 more source