Results 91 to 100 of about 110,429 (168)

Optimized Genome‐Wide Profiling of Centromeric Chromatin Complexes by ChIP‐seq

Current Protocols, Volume 6, Issue 10, October 2026.
Abstract Centromeres are specialized chromosomal regions essential for faithful chromosome segregation and genome stability. Their highly repetitive DNA composition and epigenetically defined chromatin state present significant challenges for genome‐wide profiling approaches such as chromatin immunoprecipitation followed by sequencing (ChIP‐seq ...
Alessia Daponte, Rachel Schwope, Caterina Manzari, Lucia Trisolini, Francesca Antonacci, Michele Morgante, Mario Ventura, Glennis A. Logsdon, Claudia R. Catacchio   +8 more
wiley   +1 more source

Graft Biology in the CRISPR Era: From Tissue Fusion to Genome Compatibility

Plant-Environment Interactions, Volume 7, Issue 5, October 2026.
ABSTRACT Plant lineage has traditionally constrained grafting compatibility, with monocots generally considered incompatible because of their dispersed vascular bundles and limited secondary growth. Recent studies have shown that embryonic grafting can establish successful graft unions in selected monocot systems by exploiting early developmental ...
Melagani Subash Chandra Gowda Sahaja, Melagani Subash Chandra Gowda Sahana, Revathi Thottathil, Chithra Rekha, Poomangalath Priyada, Vidhu Sankar Babu   +5 more
wiley   +1 more source

F-actin prevents interaction between sperm DNA and the oocyte meiotic spindle in C. elegans [PDF]

, 2017
Fertilization occurs during female meiosis in most animals, which raises the question of what prevents the sperm DNA from interacting with the meiotic spindle.
Marin, Harold C, Francis J. McNally, Panzica, Michelle T, Michelle T. Panzica, Anne-Cecile Reymann, Harold C. Marin, McNally, Francis J, Reymann, Anne-Cecile   +7 more
core   +1 more source

Nampt-mediated spindle sizing secures a post-anaphase increase in spindle speed required for extreme asymmetry

Nature Communications, 2020
Meiotic cell division in oocytes is asymmetric and requires microtubule spindle migration after anaphase-onset. Here, the authors show that Nampt, an enzyme of the Nicotinamide adenine dinucleotide (NAD) biosynthetic pathway, contributes to post-anaphase
Zhe Wei, Jessica Greaney, Wei-Guo Nicholas Loh, Hayden Anthony Homer   +3 more
doaj   +1 more source

Elamipretide Rejuvenates Oocyte Quality and Restores Female Fertility During Reproductive Aging

Aging Cell, Volume 25, Issue 10, October 2026.
We reported a novel peptide therapy showing that elamipretide restores the quality of aged oocytes for fertility by coordinately boosting oocyte nuclear and cytoplasmic maturation via activation of the VEGF signaling pathway. ABSTRACT Aging represents a major contributor to the deterioration of female fertility, with oocyte quality being the central ...
Hao‐Lin Zhang, Yue Wang, Caizhu Wang, Xin Guo, Huanhua Chen, Yu‐Xuan Hou, Xuan Wu, Zi‐Jian Wu, Wen‐Lin Pan, Rui‐Jie Ma, Ping‐Shuang Lu, Jinhui Shu, Shao‐Chen Sun   +12 more
wiley   +1 more source

MTR4: A Conserved Youth Factor for Vascular Endothelium

Aging Cell, Volume 25, Issue 10, October 2026.
Senescence‐induced SYVN1 degrades MTR4 via K638 ubiquitination. MTR4 loss disrupts its binding to BUB3 and destabilizes BUB3, diminishing BUBR1 and driving endothelial senescence. MTR4 restoration reverses vascular aging in mice and extends C. elegans lifespan.
Zhenyuan Guo, Zhiqiang Chen, Jiaqi Sun, Xiaojun Zhou, Chengzhi Ni, Yuxiang Zhang, Pengfei Qiang, Lu Zhang   +7 more
wiley   +1 more source

Bipolar meiotic spindle formation without chromatin.

, 1998
International audienceEstablishing a bipolar spindle is an early event of mitosis or meiosis. In somatic cells, the bipolarity of the spindle is predetermined by the presence of two centrosomes in prophase. Interactions between the microtubules nucleated
Maro, Bernard, Brunet, Stéphane, Verlhac, Marie-Hélène, Polanski, Zbigniev, Kubiak, Jacek   +4 more
core   +2 more sources

A DRACH Observed/Expected Metric Reveals the Evolutionary Landscape of Epitranscriptomic Regulation Across Bilateria

Annals of the New York Academy of Sciences, Volume 1564, Issue 1, October 2026.
Epitranscriptomic marks are highly variable across life stages and tissues, complicating comparisons between species. Using m6A consensus motifs, we developed a genomic indicator reflecting transcript methylability, the DRACH o/e score, that we used to investigate epitranscriptomic features and associated functions across nine bilaterian species.
Natacha Clairet, Jérémy Le Luyer, Hélène Auger, Maximilian Haeussler, Guillaume Rivière   +4 more
wiley   +1 more source

pgen.1010363.t003 - C. elegans XMAP215/ZYG-9 and TACC/TAC-1 act at multiple times during oocyte meiotic spindle assembly and promote both spindle pole coalescence and stability

, 2023
pgen.1010363.t003 - C. elegans XMAP215/ZYG-9 and TACC/TAC-1 act at multiple times during oocyte meiotic spindle assembly and promote both spindle pole coalescence and ...
Austin M. Harvey (5512664), Eisuke Sumiyoshi (14341784), Bruce Bowerman (36761), Chien-Hui Chuang (60706)   +3 more
core   +1 more source

MIS12 Is Required for Kinetochore‐Microtubule Attachment in Oocyte Meiosis

Advanced Science, Volume 13, Issue 51, 14 September 2026.
A model depicting the role of MIS12 in K‐MT attachment during oocyte meiosis. The presence of MIS12 stabilizes bipolar K‐MT attachments by maintaining the function of NDC80 and its interaction with TUBB. This, in turn, promotes KNL1 assembly and subsequent SAC protein recruitment to kinetochores.
Jian Li, Chun‐Hui Zhang, Yong Wang, Cheng‐Yuan Li, Da‐Rong Wen, Xi Xia, Liang Zhou, Wei‐Ping Qian, Qing‐Yuan Sun, Chang‐Zhong Li   +9 more
wiley   +1 more source