Results 111 to 120 of about 18,808 (211)

Multiple requirements of PLK1 during mouse oocyte maturation.

PLoS ONE, 2015
Polo-like kinase 1 (PLK1) orchestrates multiple events of cell division. Although PLK1 function has been intensively studied in centriole-containing and rapidly cycling somatic cells, much less is known about its function in the meiotic divisions of ...
Petr Solc, Tomoya S Kitajima, Shuhei Yoshida, Adela Brzakova, Masako Kaido, Vladimir Baran, Alexandra Mayer, Pavlina Samalova, Jan Motlik, Jan Ellenberg   +9 more
doaj   +1 more source

An ATM and ATR dependent checkpoint inactivates spindle assembly by targeting CEP63

, 2010
The effects of ATM and ATR signalling induced by chromosomal breakage have been described extensively in modulating cell cycle progression up to the onset of mitosis.
Smith, E.A.
core  

Asymmetric Positioning and Organization of the Meiotic Spindle of Mouse Oocytes Requires CDC42 Function

, 2006
SummaryThe mature mammalian oocyte is highly polarized because asymmetrical spindle migration to the oocyte cortex ensures extrusion of small polar bodies in the two meiotic divisions, essential for generation of the large egg.
Na, Jie, Zernicka-Goetz, Magdalena
core   +1 more source

To Make a Long Spindle Short: Nuclear Envelope Breakdown during Meiosis

Cell Reports, 2018
In fission yeast, the nuclear envelope (NE) remains intact during mitosis and meiosis I but is compromised during meiosis II. In this issue of Cell Reports, Flor-Parra et al.
Joseph M. Varberg, Sue L. Jaspersen
doaj   +1 more source

Investigation into how mitotic spindle checkpoint function is compromised by Sv40 large T antigen.

, 2005
The viral oncoprotein Simian virus 40 large T antigen (LT) efficiently immortalises primary rodent cells and occasionally transforms them to tumourigenicity.
Lock, Rowena Lesley, Lock, R.L.
core  

Bod1, a novel kinetochore protein required for chromosome biorientation [PDF]

, 2007
We have combined the proteomic analysis of Xenopus laevis in vitro–assembled chromosomes with RNA interference and live cell imaging in HeLa cells to identify novel factors required for proper chromosome segregation. The first of these is Bod1, a protein
McClelland, Sarah E., Khoudoli, Guennadi A., Swedlow, Jason R.; id_orcid, Andersen, Jens S., McAinsh, Andrew D., Andrew D. McAinsh, Swedlow, Jason R, Iain M. Porter, J. Julian Blow, Khoudoli, Guennadi A, Hunter, Christopher J., Blow, J. Julian; id_orcid, Guennadi A. Khoudoli, Jason R. Swedlow, Hunter, Christopher J, Sarah E. McClelland, Porter, Iain M, Porter, Iain M., Blow, J Julian, Andersen, Jens S; id_orcid, McClelland, Sarah E, Swedlow, Jason R., McAinsh, Andrew D, Blow, J. Julian, Jens S. Andersen, Christopher J. Hunter   +25 more
core   +1 more source

NIMA-related kinase 1 (NEK1) regulates meiosis I spindle assembly by altering the balance between α-Adducin and Myosin X.

PLoS ONE, 2017
NIMA-related kinase 1 (NEK1) is a serine/threonine and tyrosine kinase that is highly expressed in mammalian germ cells. Mutations in Nek1 induce anemia, polycystic kidney and infertility.
Miguel A Brieño-Enríquez, Stefannie L Moak, J Kim Holloway, Paula E Cohen   +3 more
doaj   +1 more source

Assessment of oocyte quality in polycystic ovarian syndrome and endometriosis by spindle imaging and reactive oxygen species levels in follicular fluid and its relationship with IVF-ET outcome

Journal of Human Reproductive Sciences, 2012
Objectives: The aim of this study is to examine meiotic spindle in oocytes along with reactive oxygen species (ROS) levels in follicular fluid of women undergoing IVF and to correlate these findings with embryo quality and pregnancy outcome.
Shweta Rajani, Ratna Chattopadhyay, Sourendra K Goswami, Sanghamitra Ghosh, Sunita Sharma, Baidyanath Chakravarty   +5 more
doaj   +1 more source

Microtubule-severing activity of the AAA+ ATPase Katanin is essential for female meiotic spindle assembly.

, 2016
International audienceIn most animals, female meiotic spindles are assembled in the absence of centrosomes. How microtubules (MTs) are organized into acentrosomal meiotic spindles is poorly understood.
Dumont, Julien, Joly, Nicolas,, Pintard, Lionel, Martino, Lisa, Gigant, Emmanuelle, Joly, Nicolas   +5 more
core   +1 more source

Arabidopsis Cell Division Cycle 20.1 Is Required for Normal Meiotic Spindle Assembly and Chromosome Segregation

, 2015
Cell division requires proper spindle assembly; a surveillance pathway, the spindle assembly checkpoint (SAC), monitors whether the spindle is normal and correctly attached to kinetochores.
Copenhaver, Gregory P., Ma, Hong, Wang, Yingxiang, Zhang, Liangsheng   +3 more
core   +1 more source